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Long noncoding RNA CLMAT1 related with colorectal liver metastasis and application of long non-coding RNA CLAMT1

A long-chain non-coding, colorectal cancer technology, applied in DNA/RNA fragments, recombinant DNA technology, microbial assay/inspection, etc., can solve problems such as stay

Active Publication Date: 2014-11-12
ZHONGSHAN HOSPITAL FUDAN UNIV
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Problems solved by technology

However, so far, reports on lncRNAs and colorectal cancer metastasis are still at the level of single lncRNA expression verification, and there is no literature that directly reports systematic research on the expression profile and function of CLM-related lncRNAs.

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  • Long noncoding RNA CLMAT1 related with colorectal liver metastasis and application of long non-coding RNA CLAMT1
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  • Long noncoding RNA CLMAT1 related with colorectal liver metastasis and application of long non-coding RNA CLAMT1

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Embodiment Construction

[0026] In order to make the present invention more comprehensible, preferred embodiments are described in detail below with accompanying drawings.

[0027] The clinical specimens adopted in the present invention meet the following conditions:

[0028] The colorectal cancer tissue samples used in the present invention are all from the colorectal cancer and CLM tissue sample bank established in the early stage by the intestinal cancer research group of Zhongshan Hospital Affiliated to Fudan University. The collection and research of all colorectal cancer tissue specimens were approved by the medical ethics committee of the hospital, and all patients had signed informed consent. The cancer tissue and the normal mucosa at the distal end of the cancer (>10cm away from the colorectal cancer lesion) were collected from each colorectal cancer tissue specimen. Fresh specimens were washed with normal saline three times, and necrotic tissue, connective tissue and adipose tissue were rem...

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Abstract

The invention provides long noncoding RNA (ribonucleic acid) CLMAT1 related with colorectal liver metastasis and application of the long noncoding RNA CLAMT1. The long noncoding RNA CLAMT1 is positioned at a 14th chromosome chr14: 101379770-101381326, hg19; the gene sequence length is 1557bp. Compared with normal intestinal tissues, intestinal tissues with the intestinal cancer has high expression of CLAMT1 which is positively correlated with liver metastases of colorectal cancer; in addition, bad prognosis of patients also indirectly prompts that the liver metastasis probability of the patients is relatively high.

Description

technical field [0001] It is used to diagnose the occurrence of colorectal cancer liver metastasis, evaluate the prognosis of colorectal cancer patients, and reveal the potential mechanism of colorectal cancer liver metastasis from the perspective of long non-coding RNA. Background technique [0002] The incidence of colorectal cancer in my country is increasing year by year, especially in Beijing, Shanghai and other cities, where it ranks first in digestive tract tumors. The liver is the most important target organ for hematogenous metastasis of colorectal cancer, and it is also the main factor affecting the prognosis of colorectal cancer. 15% to 25% of colorectal cancer patients have liver metastases at the time of diagnosis, and another 15% to 25% of patients develop liver metastases after radical resection of the primary colorectal cancer. Colorectal liver metastasis (CLM) is also the leading cause of death in colorectal cancer patients. The median survival time of untr...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/113C12Q1/68
Inventor 许剑民叶乐驰韦烨任黎钟芸诗朱德祥常文举林奇
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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