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Method for simultaneously determining 15 forbidden androgens in cosmetics

A technology for androgen and cosmetics, applied in the field of simultaneous determination of 15 prohibited androgen in cosmetics, can solve the problems of skin atrophy and thinning, pigmentation, etc., and achieve the effect of good separation, accurate method and high signal response intensity

Active Publication Date: 2014-12-03
CHINESE ACAD OF INSPECTION & QUARANTINE
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AI Technical Summary

Benefits of technology

In this patented process called Ultrap High Performance Liquid Chromato Grape (UHPLC) analysis or mass spectral analysis, it allows us to accurately identify harmful substances such as benzene sulfate used during makeup without being able to distinguish between these two chemical groups. It also includes methods like Luminescence Resonance Energy Transfer (LET), XRF, Raman scattering spectroscopy, Gas Chemistry Analysis (GCA). These techniques allow researchers to study and verify their use of certain materials while avoiding false alarms caused by other ingredients found within them.

Problems solved by technology

The technical problem addressed by this patented method relates to improving the security and purification of certain chemical compounds called orrostane (a type of ester) found naturally within human beings during their production process. This natural product may come into play when these molecules were harmful materials discovered through various methods such as mass spectrometry analysis.

Method used

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  • Method for simultaneously determining 15 forbidden androgens in cosmetics
  • Method for simultaneously determining 15 forbidden androgens in cosmetics
  • Method for simultaneously determining 15 forbidden androgens in cosmetics

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Embodiment

[0044] 1. Instruments, reagents and materials

[0045] ACQUITY ultra-high performance liquid chromatography, Waters XEVO TQ triple quadrupole mass spectrometer, MassLynx data processing system (Waters, USA); Milli-Q ultrapure water device (Millipore, USA); CR 21G high-speed refrigerated centrifuge (Japan Hitachi Company); KQ-600 Ultrasonic Cleaner (Kunshan Ultrasonic Instrument Co., Ltd., Jiangsu Province); MS2 Vortex Oscillator (German IKA Company); AB204-S Electronic Balance (U.S. METTLER TOLEDO Company); N-EVP 112 Nitrogen blowing instrument (Organomation Associates Inc, U.S.); 0.22 μm microporous membrane (Pall, U.S.); Oasis HLB (60mg, 3mL) solid-phase extraction column (Waters, U.S.); methanol, acetonitrile and formic acid are chromatographically pure reagents (Fisher Corporation, USA).

[0046] The structural formulas and relevant information of the 15 prohibited androgen substances are shown in Table 3.

[0047] Using methanol as a solvent, prepare standard stock solu...

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Abstract

The invention discloses a method for simultaneously determining 15 forbidden androgens in cosmetics. The method comprises the following steps: (1) preprocessing a sample: extracting, purifying and concentrating the sample; (2) analyzing and determining the preprocessed sample by adopting an ultrahigh-efficient liquid chromatography-mass spectrometry/mass spectrometry. The method can simultaneously determine 15 forbidden androgens including adrenosterone, trenbolone, boldenone, fluoxymesterone, oxandrolone, androstenedione, nandrolone, metandienone, testosterone, dehydroepiandrosterone, clostebol, androstanolone, mestanolone, chlorotestosterone acetate and testosterone propionate. The method for simultaneously determining the 15 forbidden androgens in the cosmetics is accurate, rapid and sensitive. According to the method, effective scientific evidence and technical support can be provided for the inspection work of cosmetics and the quality control of the daily production.

Description

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Claims

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Application Information

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Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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