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A method for simultaneous determination of 15 banned androgens in cosmetics

A technology for androgen and cosmetics, applied in the field of simultaneous determination of 15 prohibited androgen in cosmetics, can solve the problems of skin atrophy and thinning, pigmentation, etc., and achieve the effect of good separation, accurate method and high signal response intensity

Active Publication Date: 2016-05-11
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Androgens are steroid hormones that can directly act on the skin. In the short term, they can promote skin elasticity, reduce wrinkles, treat acne, and promote hair growth. However, if used for a long time, it will cause pigmentation, skin atrophy and thinning and other side effects

Method used

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  • A method for simultaneous determination of 15 banned androgens in cosmetics
  • A method for simultaneous determination of 15 banned androgens in cosmetics
  • A method for simultaneous determination of 15 banned androgens in cosmetics

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Embodiment

[0044] 1. Instruments, reagents and materials

[0045] ACQUITY ultra-high performance liquid chromatography, WatersXEVOTQ triple quadrupole mass spectrometer, MassLynx data processing system (Waters, USA); Milli-Q ultrapure water device (Millipore, USA); CR21G high-speed refrigerated centrifuge (Hitachi, Japan) ; KQ-600 ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd., Jiangsu Province); MS2 vortex oscillator (German IKA company); AB204-S electronic balance (US METTLERTOLEDO company); N-EVP112 nitrogen blowing instrument ( U.S. Organomation Associates Inc); 0.22 μm microporous membrane (U.S. Pall company); OasisHLB (60mg, 3mL) solid-phase extraction column (U.S. Waters company); Methanol, acetonitrile and formic acid are chromatographically pure reagents (U.S. Fisher company).

[0046] The structural formulas and relevant information of the 15 prohibited androgen substances are shown in Table 3.

[0047] Using methanol as a solvent, prepare standard stock solutions...

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Abstract

The invention discloses a method for simultaneously determining 15 forbidden androgens in cosmetics. The method comprises the following steps: (1) preprocessing a sample: extracting, purifying and concentrating the sample; (2) analyzing and determining the preprocessed sample by adopting an ultrahigh-efficient liquid chromatography-mass spectrometry / mass spectrometry. The method can simultaneously determine 15 forbidden androgens including adrenosterone, trenbolone, boldenone, fluoxymesterone, oxandrolone, androstenedione, nandrolone, metandienone, testosterone, dehydroepiandrosterone, clostebol, androstanolone, mestanolone, chlorotestosterone acetate and testosterone propionate. The method for simultaneously determining the 15 forbidden androgens in the cosmetics is accurate, rapid and sensitive. According to the method, effective scientific evidence and technical support can be provided for the inspection work of cosmetics and the quality control of the daily production.

Description

technical field [0001] The invention relates to a method, in particular to a method for simultaneously determining 15 prohibited androgens in cosmetics. Background technique [0002] In recent years, with the rapid development of the national economy and the continuous improvement of people's living standards, my country has become a major consumer of cosmetics in the world. Consumers have a more rational consumption concept, not only purely pursuing the brand effect of cosmetics, but also paying more attention to the cosmetics themselves. safety. Androgens are steroid hormones that can directly act on the skin. In the short term, they can promote skin elasticity, reduce wrinkles, treat acne, and promote hair growth. However, if used for a long time, it will cause pigmentation, skin atrophy and thinning and other side effects. my country's cosmetics hygiene standards, cosmetics hygiene standards, and EU cosmetics regulations clearly stipulate that androgen is a prohibited su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88G01N30/06G01N30/28G01N30/30G01N30/32
Inventor 马强李晶瑞白桦孟宪双张庆马会娟陈云霞王元成
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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