Ion mobility spectrometer with high throughput

An ion mobility, ion technology, used in mass spectrometers, dynamic spectrometers, electron/ion optics, etc., to solve problems such as limited binding, charge throughput, dynamic range, speed and resolution limitations

Inactive Publication Date: 2018-05-04
LECO CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In summary, state-of-the-art IMS and IMS-TOF are limited in their charge throughput, dynamic range, speed, and resolution, limiting their incorporation into rapid separation methods

Method used

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  • Ion mobility spectrometer with high throughput
  • Ion mobility spectrometer with high throughput
  • Ion mobility spectrometer with high throughput

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Experimental program
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Embodiment 27

[0060] Embodiment 27C utilizes a novel implementation. It is believed that the RF field affects the resolution force in IMS due to ion heating. From ion optics simulations, it is clear that the RF field generally does not affect resolution, but rather introduces a time delay between the axial fraction of the ion not excited by the RF field compared to the radial fraction of the ion excited by the RF field. Thus, IMS resolving power can be restored with efficient bulk mixing of the two fractions, or by exposing all ions to approximately the same RF excitation. This implementation allows the use of radial confinement of ions by means of RF fields without compromising IMS resolving power in cylindrical and conical ion guides.

[0061] Since the ions are confined by radial RF barriers and DC radial repulsion, the cylindrical migration cell can be operated without loss of ions, and without the extra temporal dispersion that often occurs in RF ion guides. If RF confinement is appl...

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Abstract

A method and apparatus are disclosed for improving ion mobility spectrometry by utilizing a fast and spatially wide ion gate based on a localized RF field barrier as opposed to a switched DC field. On the other hand, the speed and charge throughput of ion mobility separators are improved by arranging coaxial transfer cells followed by tapered coaxial ion channels. The improvements speed up ion mobility analysis and improve the charge throughput and dynamic range of IMS. The present invention is particularly suitable for fast two-stage gas chromatography, fast CE. Preferably, the accelerated and large aperture IMS is coupled to a multiple reflection time-of-flight mass spectrometer with fast coded orthogonal acceleration. The speed and sensitivity of IMS with fast-pulse MR‑TOF make it feasible to deploy integrated and orthogonally separated analytical approaches in multiple analytical dimensions.

Description

technical field [0001] The present disclosure relates to the field of ion mobility spectroscopy, and more particularly, to improving ion mobility spectroscopy for integration with liquid and gas chromatography, multidimensional gas chromatography, and mass spectrometry. Background technique [0002] Ion mobility spectrometry (IMS) is widely used to analyze ionized compounds in terms of their mobility, which is a function of ion charge, mass, and shape. A typical IMS consists of an ion source for soft ionization of the analyte, an ion gate (typically a Tyndal gate) to form short ion packets, a gas-filled drift tube for ion separation in an electrostatic field, and collection of time-dependent signals for measurement device. As an independent analytical technique, IMS has generally low resolution (roughly between 50-100). IMS has been primarily viewed as a low-cost handheld system and method for the detection of toxic volatile compounds because of its generally low detection...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/62
CPCH01J49/00H01J49/06G01N27/623H01J49/061H01J49/40
Inventor A·N·维尔恩驰寇韦
Owner LECO CORPORATION
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