A kind of clonidine hydrochloride dry suspension and preparation method thereof

Abstract

The invention provides a clonidine hydrochloride dry suspension and a preparation method thereof. The clonidine hydrochloride dry suspension comprises 40-90 parts of clonidine hydrochloride, 500-2000 parts of a filler, 50-180 parts of a corrigent, 40-100 parts of a suspending aid and 10-40 parts of a flocculant. The clonidine hydrochloride dry suspension provided by the invention is uniform in distribution, good in stability, large in distribution area in the stomach and intestines, fast to absorb and high in bioavailability, fast takes effect, and has medicinal effect superior to that of a clonidine hydrochloride premix.

Description

technical field [0001] The invention relates to a dry suspension, in particular to a clonidine hydrochloride dry suspension and a preparation method thereof. Background technique [0002] Dry suspensions refer to insoluble drugs and suitable excipients made into powders or granules, which can be dispersed into suspensions for oral administration by adding water and shaking before use. The dry suspension belongs to the suspension. After adding water to disperse, it should meet the quality requirements of the suspension. The particles in the suspension should be uniformly dispersed and should not be weighed quickly. It should be quickly redispersed. In addition to being effective and chemically stable, an ideal suspension should (1) settle slowly and be able to redisperse by shaking gently after settling; (2) the size of the suspended particles should remain unchanged during long-term storage (3) Easy to dump. The above is the physical stability of the suspension. Dry susp...

AI Technical Summary

Problems solved by technology

[0005] In order to solve the shortcomings of poor water solubility and low bioavailability of existing clonidine hydrochloride, the present invention invented clonidine hydrochloride dry suspension

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