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A kind of cefquinome sulfate oil suspension injection and preparation method thereof

A cefquinoxime sulfate and oily suspension technology, which is applied in the field of medicine, can solve the problems of poor dispersibility, easy precipitation, unstable content detection, etc., and achieves good compatibility, good needle penetration, and guaranteed dosage and uniformity. Effect

Active Publication Date: 2017-07-21
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are some suspension injection dosage forms in the prior art, but when they are compatible with oil-emulsion vaccines, there are shortcomings such as easy precipitation, layering, poor dispersion, and unstable content detection, which cannot fully exert their efficacy

Method used

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  • A kind of cefquinome sulfate oil suspension injection and preparation method thereof
  • A kind of cefquinome sulfate oil suspension injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A cefquinoxime sulfate oily suspension injection, the 100ml injection comprises the following components: cefquinoxime sulfate 2.5g, BHT 0.1g, benzyl alcohol 1.0g, Tween-40 3.0g, Span-80 1.0 g, aluminum stearate 1.0 g, glycerol triabietate 0.3 g, ethyl oleate 60 g, and the balance is soybean oil for injection.

[0033] Its preparation method is:

[0034] 1) Add aluminum stearate to ethyl oleate, stir until uniformly dispersed, heat it to 120°C, at this time the solution system is clear and transparent, keep it for 30 minutes, cool down to 80°C, add BHT, after melting, Stir evenly, cool to room temperature, add benzyl alcohol and glycerol triabietate, stir evenly to form a mixed solution system;

[0035] 2) Add Tween-40 and Span-80 into the mixed solution system obtained in step 1), and stir evenly to obtain system A;

[0036] 3) Add cefquinome sulfate to a part of soybean oil for injection, adjust the gap between the stator and rotor of the colloid mill to 15 μm, and ...

Embodiment 2

[0040] A cefquinoxime sulfate oily suspension injection, the 100ml injection comprises the following components: cefquinoxime sulfate 10g, vitamin E 0.5g, benzyl alcohol 3.0g, Tween-40 3.0g, Span-80 2.0 g, 5.0 g of hydrogenated castor oil, 0.1 g of glycerol triabietate, 20 g of No. 10 white oil, 30 g of ethyl oleate, and the balance is soybean oil for injection.

[0041] 1) Mix No. 10 white oil and ethyl oleate evenly, add hydrogenated castor oil, stir evenly, then add vitamin E oil and benzyl alcohol, stir evenly, then add glycerol triabietin, stir evenly to form a solution system;

[0042] 2) Add Tween-40 and Span-80 to the resultant of step (a), and stir evenly to obtain system A;

[0043]3) Add cefquinome sulfate to some soybean oil for injection, adjust the gap between the stator and rotor of the colloid mill to 15 μm, and grind for 10 minutes to obtain system B;

[0044] 4) Add systems A and B into the mixing tank, stir and mix evenly, and make the volume to 100ml with ...

Embodiment 3

[0047] A cefquinoxime sulfate oily suspension injection, the 100ml injection comprises the following components: cefquinoxime sulfate 10.0g, BHT 0.5g, benzyl alcohol 1.0g, Tween-40 5.0g, Span-80 1.0 g, 2.0 g of aluminum stearate, 1.0 g of glycerol triabietate, 20 g of ethyl oleate, 20 g of diacetate, 10 g of No. 10 white oil, and the balance is soybean oil for injection.

[0048] Its preparation method refers to embodiment 1.

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Abstract

The invention belongs to the technical field of medicine, and in particular relates to a cefquinome sulfate oily suspension injection and a preparation method thereof. The 100ml injection includes the following components: 0.1-10.0 g of cefquinome sulfate, 0.05-0.5 g of antioxidants , bacteriostatic agent 1.0~3.0g, emulsifier 0.5~7.0g, suspending agent 0.1~5.0g, thixotropic agent 0.1~1.0g, the balance is oil for injection, the preparation method includes the following steps: dispersing the suspending agent To a part of the oil for injection, add antioxidants and bacteriostatic agents in turn, stir, add an emulsifier and stir to obtain a solution system; add cefquinoxime sulfate to a part of the oil for injection, grind to obtain a solution system; two solutions The system is mixed, and the oil for injection is adjusted to 100ml; sterilized. The injection of the invention has good compatibility and compatibility with the commonly used oil-emulsion vaccines for livestock and poultry, and can be combined with acupuncture to reduce workload;

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cefquinome sulfate oily suspension injection and a preparation method thereof. Background technique [0002] Cephalosporin antibiotics, also known as cephalosporins, are a class of broad-spectrum antimicrobial semi-synthetic antibiotics. They all have a β-lactam ring in their structure and belong to β-lactam antibiotics. Compared with penicillins, it has the characteristics of less toxicity, fewer allergic reactions, enhanced stability to acid and β-lactamase, and less hydrolysis, so it is more widely used in clinical practice. According to the discovery time of this class of drugs, they are divided into first, second, third, and fourth-generation cephalosporins. The first-generation cephalosporins are mainly cephalothin and cephalexin, which are mainly for Gram-positive bacteria. The effect is obvious, but it has certain toxicity to the kidneys, and the antibacte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K31/546A61K47/14A61K47/22A61K47/26A61P11/00A61P31/04A61P31/16
Inventor 郭建军李凌峰管倩李会芳
Owner HENAN SOAR VETERINARY PHARMA
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