Xu Changqing c21 steroid conversion product and its application

A transformation product, Xu Changqing's technology, applied in the field of medicine, can solve the problems of no high content, no research reports on tumor cell multidrug resistance reversal agents, etc.
CN104758332BInactive Publication Date: 2018-01-26QINGDAO UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
QINGDAO UNIV
Publication Date
2018-01-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a Xu Changqing C21 steroid transformation product and its application in the preparation of a multidrug resistance reversal agent for tumor cells. The weight percentage of C21 steroid aglycone in the transformation product is greater than or equal to 90%, which can reverse the multidrug resistance of human gastric cancer. Drug-resistant cells, multidrug-resistant cells of human colon cancer, and multidrug-resistant cells of human lung cancer are resistant to commonly used clinical drugs paclitaxel, doxorubicin, 5-fluorouracil, and cisplatin, and also provide preparation of Xu Changqing's C21 steroid transformation product The method and the preparation method are simple and convenient. The Xu Changqing C21 steroid transformation product of the present invention is used in combination with antineoplastic drugs in clinic to improve the curative effect of chemotherapy and has broad application prospects.
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Description

technical field

[0001] The invention belongs to the field of medicine, and relates to Xu Changqing's C21 steroid conversion product and its application in preparing tumor cell multidrug resistance reversal agents, and also relates to a preparation method of Xu Changqing's C21 steroid conversion product. Background technique

[0002] Malignant tumor is one of the diseases that seriously endanger human health. It is characterized by abnormal cell proliferation and metastasis. Statistics from the World Health Organization show that in 2000, there were about 10 million new cases of malignant tumors in the world, 6.2 million deaths, and 22 million cases of illness; it is estimated that by 2020, there will be 15 million new cases of malignant tumors, 10 million deaths, and 30 million illnesses. Thousands of cases. Chemotherapy is one of the methods of comprehensive therapy for malignant tumors. It is widely used before, during and after surgery. However, the phenomenon of multidr...

Claims

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