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34 results about "C21 steroid" patented technology

Application of C21 steroid glycoside in pharmacy

The invention discloses the use of C21 steroid glycoside in pharmacy, wherein the systematic test shows that C21 steroid glycocide has low toxic and side effect, but has unique effect for treating psychogenia diseases with depression state, in particular for depression.
Owner:YUNNAN BAIYAO GROUP

C21 steroid saponin aglycone derivative as well as preparation method and application thereof in preparing anti-tumor drugs

The invention discloses a C21 steroid saponin aglycone derivative as well as a preparation method and an application thereof in preparing anti-tumor drugs. The structural formula of the C21 steroid saponin aglycone derivative is as shown in formula IX. The C21 steroid saponin aglycone derivative disclosed by the invention has the advantages of being better in bioactivity, higher in selectivity, lower in toxicity and the like. The C21 steroid saponin aglycone derivative has a significant inhibitory effect on human breast cancer cells, cervical cancer cells, lung cancer cells and liver cancer cells (as shown in Specification), wherein R1 is selected from H and F, R2 is selected from H and F, and R3 is selected from H and F.
Owner:JIANGSU NAIQUE BIOLOGICAL ENG

C21 steroid 21 site acetylation process

The invention discloses a C21 steroid 21 site acetylation process. C21 steroid is prednisolone, hydrocortisone, dexamethasone or betamethasone; the C21 steroid is subjected to acetylation with aceticanhydride; the acetylation of the C21 steroid with the acetic anhydride is carried out in a mixed solvent; an acetic acid alkali metal salt is adopted as a catalyst, and the reaction is carried out inthe presence of an inert gas; the mixed solvent is a mixed solvent of tetrahydrofuran and acetone; the weight ratio of the tetrahydrofuran to the acetone in the mixed solvent is (2-9):1. High-toxicity and high ammonia nitrogen pyridine and dimethylformamide are replaced by using the mixed solvent of tetrahydrofuran and acetone without ammonia nitrogen, no high ammonia nitrogen wastewater is generated, and environment pollution can be reduced.
Owner:HENAN LIHUA PHARMA

Application of glaucescent fissistigma root extract C21 steroid in preparation of medicine for promoting gastric cancer cell apoptosis

The invention discloses application of a C21 steroid in preparation of a medicine for promoting cancer cell apoptosis. The C21 steroid inhibits cell proliferation by inhibiting autophagy to promote cell apoptosis. The invention further discloses application of the C21 steroid in preparation of a medicine for treating gastric cancer; the C21 steroid is a glaucescent fissistigma root extract; and the C21 steroid inhibits proliferation of gastric cancer cells by inhibiting autophagy and promoting apoptosis. The C21 steroid disclosed by the invention can obviously inhibit the growth of cancer cells and promote the cell apoptosis, and provides a theoretical basis for revealing a new mechanism of the anti-gastric cancer activity of the C21 steroid.
Owner:ZHEJIANG PROVINCIAL PEOPLES HOSPITAL

Furan skeleton included 2H-pyrazole hydroxamic acid C21 steroid saponin aglycone derivative and preparation method and application thereof

The invention discloses a furan skeleton included 2H-pyrazole hydroxamic acid C21 steroid saponin aglycone derivative and a preparation method and an application thereof. The structure of the derivative is shown as the formula VIII (img file = 'DDA 000709386530000011. TIF' wi= '882' he= '498' / ), R1 is selected from H and CH3; R2 is selected from H and F. The derivative has an apparent inhibiting effect on human breast cancer cells (MCF-7), cervical cancer cells (HeLa), lung carcinoma cells (A549) and hepatoma carcinoma cells (HepG2), and cytotoxicity equivalent to or higher than positive control drugs Celecoxib is presented to human kidney epithelial cells (293T), and the derivative can be applied to preparation of antitumor drugs.
Owner:JIANGSU NAIQUE BIOLOGICAL ENG

C21 steroid compound in marsdenia tenacissima and preparation method and application thereof

The invention belongs to the technical field of medicine, relates to a method for preparing a C21 steroid compound in marsdenia tenacissima and an application of the C21 steroid compound to the field of osteoporosis prevention and treatment, and discloses the C21 steroid compound as shown in the formula (I) and the formula (II) and salt of the C21 steroid compound. R1-R5 can be described as the specification and the claim. The compound has a good osteoporosis prevention and treatment function, and can be combined with acceptable carriers in pharmacy to prepare clinically-acceptable medicine to be used for treatment of osteoporosis (please see the formulas in the specification).
Owner:中国人民解放军第二一〇医院

Application of C21 steroid compounds 1-8 of cynanchum paniculatum in preparation of anti-TSWV active products

The invention provides an application of C21 steroid compounds 1-8 separated from cynanchum paniculatum in preparation of anti-TSWV (tomato spotted wilt virus) active products. Tests prove that the C21 steroid compounds 1-8 in cynanchum paniculatum have anti-TSWV activity, and show different degrees of prevention effects on TSWV. Specifically, the invention also provides an application of the C21steroid compounds 1-8 of cynanchum paniculatum in preparation of a TSWV inhibitor. When the concentrations of the compound 4 and the compound 5 are 100 [mu]g / mL, the virus content is less than that ofningnanmycin, which indicates that the prevention effect on TSWV is superior to that of commercially available antiviral pesticide ningnanmycin.
Owner:KUNMING INST OF BOTANY - CHINESE ACAD OF SCI

Bacillus cereus X-32 with high yield of C21 steroid compound and application of bacillus cereus X-32

The invention discloses bacillus cereus X-32 for high yield of a C21 steroid compound and application of the bacillus cereus X-32. The bacillus cereus X-32 is subjected to chemical character analysis and molecular identification to be bacillus cereus and is preserved in the China Center for Type Culture Collection in September 13, 2021, the preservation number is CCTCC NO: M 20211165, the preservation address is Wuhan University preservation center, Luoma, Wuchang District, Wuhan City, and the postcode is 430072. After the bacillus cereus X-32 is subjected to optimized fermentation culture, the concentration of C21 steroid in fermentation liquor reaches 1.280 + / -0.005 mg / mL, and a metabolite of the bacillus cereus X-32 is identified as cynanchum bungeanum glycoside C1N. The bacillus cereus X-32 is a new way for synthesizing the C21 steroid compound by microorganisms, and has the advantages of few synthesis steps, short production period, high conversion rate, easiness in regulation and control of the fermentation process, environmental friendliness and the like.
Owner:YANCHENG TEACHERS UNIV

Agrobacterium tumefaciens F-45 with high yield of C21 steroidal glycoside and application of Agrobacterium tumefaciens F-45

The invention discloses Agrobacterium tumefaciens F-45 with the high yield of C21 steroidal glycoside and application of the Agrobacterium tumefaciens F-45. The endophytic actinomycetes are screened from coastal radix cynanchi bungei plants in a planting base of Fuli radix polygoni multiflori in coastal county of Jiangsu province, the strains are separated and purified by utilizing plate streaking, numbered and preserved, the used parent strains are subjected to physical character analysis, 16SrDNA primer amplification and sequence determination and analysis, and the identification result is agrobacterium tumefaciens F-45. The Agrobacterium tumefaciens F-45 is preserved in the China Center for Type Culture Collection in September 13, 2021, the preservation number is CCTCC NO: M 20211166, the preservation address is Wuhan University preservation center, Luoma, Wuchang District, Wuhan, and the postal code is 430072. the agrobacterium tumefaciens F-45 is short in growth cycle, easy in metabolism control, easy in strain breeding and large-scale fermentation industrial production, and can be used as a dominant strain for producing C21 steroid compounds.
Owner:YANCHENG TEACHERS UNIV

Pyrazoline sulfanilamide C21 steroid saponin aglycone derivative containing naphthalene skeleton, as well as preparation method and application of derivative

The invention discloses a pyrazoline sulfanilamide C21 steroid saponin aglycone derivative containing a naphthalene skeleton, a preparation method of the derivative, and an application in preparing an anti-tumor drug. A structural formula of the derivative is as shown as Formula VI as shown in the specification, wherein R1 is selected from H or CH3; R2 is selected from H, CH3, CF2, Cl or Br; R3 is selected from H, CH3 or Br; and R4 is selected from H or CH3. The derivative has the advantages of better bioactivity, higher selectivity, lower toxicity and the like and has an obvious inhibiting effect on human breast cancer cells, cervical cancer cells, lung cancer cells and liver cancer cells.
Owner:JIANGSU NAIQUE BIOLOGICAL ENG

Cynanchum bungei Decne extract, and preparation method and application thereof in blood sugar reduction

The invention discloses a Cynanchum bungei Decne extract, and a preparation method and application thereof in blood sugar reduction. The Cynanchum bungei Decne extract is an extract taking C21 steroid saponin and aglycone as main components, wherein the extract taking C21 steroid saponin and aglycone as main components is Caudatinin or Qingyangshengenin. The preparation method comprises the following steps: cleaning Cynanchum bungei Decne root tubers, drying in the sun, and pulverizing to obtain fine powder; performing cold soaking or heating reflux on the Cynanchum bungei Decne root tuber fine powder with organic solvent, and performing reduced-pressure concentration to remove the organic solvent so as to obtain an extractum; and dissolving the extractum with water to remove grease, then extracting with ethyl acetate, merging ethyl acetate extract liquids, and performing reduced-pressure concentration to remove the ethyl acetate so as to obtain a Cynanchum bungei Decne ethyl acetate extract, i.e. the Cynanchum bungei Decne extract. The Cynanchum bungei Decne extract disclosed by the invention can reduce blood sugar.
Owner:THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI +1

Pyrazoline hydroxamic acid C21 steroid saponin aglycone derivative containing naphthalene skeleton, as well as preparation method and application of derivative

The invention discloses a pyrazoline hydroxamic acid C21 steroid saponin aglycone derivative containing a naphthalene skeleton, a preparation method of the derivative and an application of the derivative in preparing an anti-tumor drug. The C21 steroid saponin aglycone derivative has a structural formula as shown as Formula IX as shown in the specification, wherein R1 is selected from H or CH3; R2 is selected from H or CH3; R3 is selected from H or CH3; and R4 is selected from H or CH3. The derivative has the advantages of better bioactivity, higher selectivity, lower toxicity and the like. The derivative has an obvious inhibiting effect on human breast cancer cells, cervical cancer cells, lung cancer cells and liver cancer cells.
Owner:JIANGSU NAIQUE BIOLOGICAL ENG

Radix radix c21 steroid extract and its preparation method and use

The invention provides a Radix Radix C21 steroid extract, a preparation method and application thereof. The dried cane of dill radix is ​​extracted with 0-100% ethanol solution, and the C21 steroid of dill radix is ​​separated by the method of macroporous adsorption resin and decolorization resin, wherein the weight percentage of C21 steroid is 50-95%. The obtained radish C21 steroid extract has been proved by pharmacological activity studies to have the effect of reversing tumor multidrug resistance, and can be used to prepare tumor cell multidrug resistance reversing agent.
Owner:QINGDAO UNIV

Furan skeleton-containing dihydropyrazolsulfanilamide C21 steroid sapogenin derivative, and preparation method and application thereof

The invention discloses a furan skeleton-containing dihydropyrazolsulfanilamide C21 steroid sapogenin derivative, and a preparation method and an application thereof. The structure of the furan skeleton-containing dihydropyrazolsulfanilamide C21 steroid sapogenin derivative is represented by formula VII shown in the specification; and in the formula VII, R1 is selected from H and CH3, and R2 is selected from H and F. The derivative has an obvious inhibition effect on human breast cancer cells (MCF-7), cervical carcinoma cells (HeLa), lung cancer cells (A549) and liver cancer cells (HepG2), has same or better cytotoxicity on human renal epithelial cells (293T) than positive control drug Celecoxib, and can be used to prepare antitumor drugs.
Owner:JIANGSU NAIQUE BIOLOGICAL ENG

C21 steroid asclepiasterol and its preparation method and its application in the preparation of tumor multidrug resistance reversal agent

Belonging to the field of natural pharmaceutical chemistry, the invention discloses a C21 steroid Asclepiasterol, a preparation method and application thereof in preparation of a tumor multidrug resistance reversal agent. The structural formula of C21 steroid Asclepiasterol is shown as the specification. The Asclepiasterol involved in the invention has low cytotoxicity, but can significantly increase the accumulation degree of antitumor drugs in drug resistant cells, can enhance the effect of antitumor drugs in inducing drug resistant cell apoptosis, and can be applied in combination with antitumor drugs to significantly inhibit the formation rate of drug resistant tumor cell colonies and obviously decline the expression level of P-gp in two drug resistant cell lines without lowering drug resistant gene expression, thus suggesting that Asclepiasterol probably affects P-gp expression at the level of transcription and translation and has a unique mechanism of action. Therefore, compared with the existing tumor multidrug resistance reversal agents, the C21 steroid Asclepiasterol provided by the invention has high reversal activity and low toxicity, and is in accordance with the high efficiency and low toxicity characteristics of antitumor drugs.
Owner:JINAN UNIVERSITY

Metaplexis japonica C21 steroid extractive, and preparation method and application of metaplexis japonica C21 steroid extractive

The invention provides a metaplexis japonica C21 steroid extractive, and a preparation method and an application of the metaplexis japonica C21 steroid extractive. The metaplexis japonica C21 steroid extractive is characterized in that dry metaplexis japonica rattan is extracted by a 0-100% alcohol solution, metaplexis japonica C21 steroids are separated by macroporous adsorption resin and decolorizing resin methods, and the weight percentage of C21 steroids is 50-95%. Proven by a research on pharmacological activities, the prepared metaplexis japonica C21 steroid extractive has the functions of reversing multiple drug resistance of a tumor, and can be used for preparing a tumor cell multi-drug resistance reversal agent.
Owner:QINGDAO UNIV

Cynanchum paniculatum (Bge.) Kitag. C21 steroid converted product and application thereof

The invention provides a Cynanchum paniculatum (Bge.) Kitag. C21 steroid converted product and application of the converted product to preparation of a tumor cell multidrug-resistant reversal agent. The weight percentage content of C21 steroid aglycon in the converted product is greater than or equal to 90%. The converted product is used for reversing the resistance to common clinic drugs, including paclitaxel, adriamycin, 5-fluorouracil and cis-platinum, of human stomach cancer multidrug-resistant cells, human colon cancer multidrug-resistant cells and human lung cancer multidrug-resistant cells. The invention further provides a preparation method of the Cynanchum paniculatum (Bge.) Kitag. C21 steroid converted product. The preparation method is simple and convenient. The Cynanchum paniculatum (Bge.) Kitag. C21 steroid converted product is applied clinically to combination with antitumor drugs to improve the curative effect of chemotherapy, and has a wide application prospect.
Owner:QINGDAO UNIV

Application of C21 steroid glycoside in pharmacy

The invention discloses the use of C21 steroid glycoside in pharmacy, wherein the systematic test shows that C21 steroid glycocide has low toxic and side effect, but has unique effect for treating psychogenia diseases with depression state, in particular for depression.
Owner:YUNNAN BAIYAO GROUP

Pyrazoline sulfanilamide C21 steride saponin aglycone derivative containing thiophene skeleton, as well as preparation method and application of derivative

The invention discloses a pyrazoline sulfanilamide C21 steride saponin aglycone derivative containing a thiophene skeleton, as well as a preparation method and an application of the derivative. The derivative takes a compound with a C21 steroid saponin mother nucleusas a starting compound, a structural modification research is carried out on the compound to form a compound as shown as the following formula as shown in the specification, R1 is H, CH3, F, Cl or Br, and R2 is H, CH3, F, Cl or Br. A pharmacological research shows that the compound has an obvious inhibiting effect on human breast cancer cells, cervical cancer cells, lung cancer cells and liver cancer cells.
Owner:JIANGSU NAIQUE BIOLOGICAL ENG

C21 steroid saponin compound in marsdenia tenacissima stem, and applications thereof

The invention relates to a C21 steroid saponin compound in marsdenia tenacissima stem, and applications thereof in preparation of medicines used for preventing and treating lung cancer. It is shown bybiological experiments that the C21 steroid saponin compound in marsdenia tenacissima stem is capable of inhibiting tumor cell migration, maintaining tumor cells at G0 / G1 phases, and releasing Cytochrome c through up-regulating of Bax and down-regulating of Bcl-2 expression, activating Caspase 3 and Caspase 9 to induce tumor cell apoptosis, and is capable of activating caspase 8 at the same time,and inducing cell apoptosis through death receptor pathway. The C21 steroid saponin compound is capable of inhibiting tumor cell migration and invading through down-regulating of MMP-2 and MMP-9 protein expression, the effect is obvious, and lung cancer preventing and treating effect is achieved.
Owner:MINZU UNIVERSITY OF CHINA

The use of black bone vine c21 steroids in the preparation of ido inhibitors

The invention belongs to the field of medicines or health products and particularly relates to Periploca forrestii C21 steroides in preparation of IDO (indoleamine-2,3-dioxygenase) inhibitors. Researches herein discover that both periplocoside G and periplocoside I have better intracellular IDO inhibitory activity than a positive control 1-MT (1-methyl-tryptophan), have significant IDO inhibitoryactivity, and are suitable for treating cancers, Alzheimer's disease, autoimmune diseases, ankylosing spondylitis, bacterial infections, cataract, mood disorders, and depression or anxiety.
Owner:NANJING BAOHE BIOTECH

Indole skeleton-containing dihydropyrazolpiperazine C21 steroid sapogenin derivative, and preparation method and application thereof

The invention discloses an indole skeleton-containing dihydropyrazolpiperazine C21 steroid sapogenin derivative, and a preparation method and an application thereof. A target compound represented by formula VIII is obtained through structural modification research by using a compound with a C21 steroid saponin parent nucleus as an initial compound. Pharmacological research results show that the compound has an obvious inhibition effect on human breast cancer cells, cervical carcinoma cells, lung cancer cells and liver cancer cells. In formula IV to the formula VIII, R1 is H or CH3, R2 is H or CH3, R3 is H or F, and R4 is H or CH3.
Owner:JIANGSU NAIQUE BIOLOGICAL ENG

C21 steroidal soap compound and its application in Tengguanteng

The invention relates to a C21 steroidal saponin compound and its application in the preparation of anti-lung cancer drugs. Biological experiment results show that the compound can inhibit tumor cell migration and keep it in G0 / G1 phase. In addition, tumor cell apoptosis can be induced by up-regulating Bax and down-regulating the expression of Bcl-2, thereby releasing Cytochrome c, and finally activating Caspase 3 and Caspase 9. It can also activate caspase 8 and induce apoptosis through the death receptor pathway. The compound of the present invention can inhibit the migration and invasion of tumor cells by down-regulating the expression of MMP-2 and MMP-9 proteins, the effect is remarkable, and the anti-lung cancer effect is achieved.
Owner:MINZU UNIVERSITY OF CHINA
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