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Green and efficient preparation method of cynanchum bungei short sugar chain C21 steroid glycoside

A technology of Radix Polygoni Multiflori and steroidal glycosides, applied in chemical instruments and methods, catalyst activation/preparation, glycoside steroids, etc., can solve the problems of serious environmental pollution and difficulty in controlling the degree of hydrolysis, and achieve reduced environmental pollution, controllable reactions, product controllable effect

Active Publication Date: 2021-04-02
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present technology provides an improved way for producing Baishwan Short Sugar Chain Steryl Glycans by enzymatic methods that are gentle on both reactants and waste materials compared to previous techniques like acids or bases. This results in higher yields of these compounds while also being more eco-friendly due to their low levels of residual solvents during production process.

Problems solved by technology

This patented problem addressed in this patents relates to finding better ways to extract valuable chemical components from plants called Bialisoxytol (C22), or other similar molecules found naturally occurring within them. These natural sources include various types of bacteria like Bacillus subtilis varies among different genera belonging to the genus Rhodobrassica.

Method used

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  • Green and efficient preparation method of cynanchum bungei short sugar chain C21 steroid glycoside
  • Green and efficient preparation method of cynanchum bungei short sugar chain C21 steroid glycoside
  • Green and efficient preparation method of cynanchum bungei short sugar chain C21 steroid glycoside

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Fe 3 o 4 @SiO 2 Preparation of nanoparticles immobilized carrier:

[0028] Fe was first prepared by a modified hydrothermal method 3 o 4 nanoparticles. Dissolve 1.2g of ferric chloride and 2.0g of sodium acetate in a beaker, add them into 20mL of ethylene glycol, stir well until the solution turns clear yellow, transfer to a polytetrafluoroethylene reactor, and react at 200°C for 12h. The magnetic nanoparticles were separated under an external magnetic field, washed several times with deionized water and ethanol, and dried in vacuum to obtain Fe 3 o 4 Nanoparticles.

[0029] Then Fe was prepared by sol-gel method 3 o 4 @SiO 2 nanoparticles. Take 0.5g of prepared Fe 3 o 4 Nanoparticles, 30mL distilled water, 100mL ethanol and 2mL ammonia water were placed in a 250mL three-necked round-bottomed flask, then 5mL tetraethyl silicate was added to 20mL ethanol, and then their mixture was added dropwise to the above reaction system, Continue to react at room tempe...

Embodiment 2

[0031] Weigh 0.5g Fe 3 o 4 @SiO 2 Nanoparticles and 30mL distilled water were placed in a 250mL three-necked round-bottomed flask. After the system was dispersed, 0.5g of acidic ionic liquid [Bmim][HSO 4 ] was dissolved in 20mL of ethanol, added dropwise to the above reaction system, and continued to react at 60°C for 2h. After the reaction, the nanoparticles were magnetically separated, washed several times with deionized water and ethanol, and dried in vacuum to obtain the immobilized ionic liquid nanoparticles.

[0032] After fully dissolving 0.5 g of Radix Polygoni Multiflori C21 steroidal glycosides with 10 mL of 70% ethanol aqueous solution, 0.5 g of immobilized ionic liquid nanoparticles were added, and hydrolyzed at 50° C. for 4 h. After the reaction is completed, the nanoparticles are magnetically separated, and the hydrolyzed product is concentrated and dried to obtain the short sugar chain C21 steroidal glycoside of Radix Polygoni Multiflori. Through high-perfor...

Embodiment 3

[0034] Weigh 0.5g Fe 3 o 4 @SiO 2 Nanoparticles and 30mL distilled water were placed in a 250mL three-necked round-bottomed flask. After the system was dispersed, 0.5g of acidic ionic liquid [Hmim][HSO 4 ] was dissolved in 20mL of ethanol, added dropwise to the above reaction system, and continued to react at 60°C for 2h. After the reaction, the nanoparticles were magnetically separated, washed several times with deionized water and ethanol, and dried in vacuum to obtain the immobilized ionic liquid nanoparticles.

[0035]After fully dissolving 0.5 g of Radix Polygoni Multiflori C21 steroidal glycosides with 10 mL of 70% ethanol aqueous solution, 0.5 g of immobilized ionic liquid nanoparticles were added, and hydrolyzed at 60° C. for 3 h. After the reaction is completed, the nanoparticles are magnetically separated, and the hydrolyzed product is concentrated and dried to obtain the short sugar chain C21 steroidal glycoside of Radix Polygoni Multiflori. Through high-perform...

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Abstract

The invention relates to a green and efficient preparation method of cynanchum bungei short sugar chain C21 steroid glycoside, and belongs to the field of natural product chemistry. According to the method, Fe3O4 magnetic nanoparticles and acidic ionic liquid are combined through covalent bonds to prepare immobilized acidic ionic liquid, the immobilized acidic ionic liquid is used as a catalyst tohydrolyze cynanchum bungei C21 steroside, the hydrolysis time is 24h, the hydrolysis temperature is 50-70 DEG C, and short sugar chain C21 steroside is prepared. After the reaction is finished, the catalyst is recycled through an external magnetic field, and can be repeatedly used after being washed and dried. The hydrolysate is obtained by petroleum ether extraction, concentration and drying, and the proportion of the short sugar chain (1-2 sugar residues) C21 steroid glycoside is 70-80%. Compared with the traditional acidolysis method, the method provided by the invention has the advantagesof mild conditions, controllable reaction, high content of short sugar chain C21 steroidal glycoside in the product, repeated use of the catalyst, less environmental pollution and the like.

Description

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Claims

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Application Information

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Owner JIANGNAN UNIV
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