C21 steroid saponin aglycone derivative as well as preparation method and application thereof in preparing anti-tumor drugs
A technology of saponin aglycone and derivatives, applied in the preparation of antitumor drugs, in the field of C21 steroidal saponin aglycone derivatives, can solve problems such as lack of in-depth research, and achieve a mild experimental environment, high selectivity, and good biological active effect
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Embodiment 1
[0064] N-methyl-4-(5-phenyl-3-((3aR,4aS,8S,10aS,11S,12S,12aS)-(8,11,12-trihydroxy)-(10a,12a-dimethyl base)-(1,2-cyclopentyl)-1,10a-b-epoxytetradecyl)-(4,5-dihydropyrazole))benzoylpiperazine (compound 22) preparation of
[0065]
[0066] Under stirring at -20°C, add the corresponding intermediate 18 (10.0mmol) and dichloromethane (25mL) obtained in step 7 to a 50mL round bottom flask in turn, and gradually add boron tribromide (5.0mmol) dropwise and continue stirring After reacting for 1 h, the reaction flask was transferred to room temperature, and the reaction was continued for 12 h. TLC tracking reaction (developing agent V AcOEt :V 正己烷 =1:2), after the reaction was completed, filtered, the solid was washed with distilled water, and finally dried in vacuum, the obtained solid was dissolved in absolute ethanol, purified by recrystallization, and the target compound 22 was obtained as crystals.
[0067] White crystals were obtained with a yield of 47.3%. m.p.221~223℃; ...
Embodiment 2
[0069] N-methyl-4-(5-(4-fluoro-phenyl)-3-((3aR,4aS,8S,10aS,11S,12S,12aS)-(8,11,12-trihydroxyl)-( 10a,12a-Dimethyl)-(1,2-cyclopentyl)-1,10a-b-epoxytetradecyl)-(4,5-dihydropyrazole))benzoyl Preparation of piperazine (compound 23)
[0070]
[0071] The preparation method refers to Example 1. White crystals were obtained with a yield of 45.5%. m.p.226~227℃; 1 H NMR (DMSO-d 6 ,300MHz)δ:8.03(d,J=8.3Hz,2H,ArH),7.73(d,J=8.1Hz,2H,ArH),7.35~7.18(m,4H,ArH),5.35(s,2H, OH), 5.19(t, J=7.1Hz, 1H, CH), 4.49(s, 1H, OH), 3.56~3.41(m, 6H, CH and CH 2 ), 3.32(d, J=6.8Hz, 1H, CH), 2.97~2.71(m, 2H, CH 2 ), 2.28(t, J=7.7Hz, 4H, CH 2 ),2.15(s,3H,CH 3 ), 2.04(t, J=5.7Hz, 1H, CH), 1.81~1.20(m, 15H, CHand CH 2 ),1.14(dd,J 1 =7.0Hz,J 2 =7.6Hz,1H,CH),0.89(s,3H,CH 3 ),0.78(s,3H,CH 3 ).ESI-MS:687.9[M+H] + .Anal.Calcd for C 40 h 51 FN 4 o 5 :C,H,N.
Embodiment 3
[0073] N-methyl-4-(5-(2-fluoro-phenyl)-3-((3aR,4aS,8S,10aS,11S,12S,12aS)-(8,11,12-trihydroxyl)-( 10a,12a-Dimethyl)-(1,2-cyclopentyl)-1,10a-b-epoxytetradecyl)-(4,5-dihydropyrazole))benzoyl Preparation of piperazine (compound 24).
[0074]
[0075] The preparation method refers to Example 1. White crystals were obtained with a yield of 44.9%. m.p.212~213℃; 1 H NMR (DMSO-d 6 ,300MHz)δ:10.56(s,1H,OH),8.03(d,J=8.1Hz,2H,ArH),7.74~7.55(m,5H,ArH and NH),7.29~7.23(m,1H,ArH ),7.15~7.07(m,1H,ArH),5.37(s,2H,OH),5.19(t,J=7.3Hz,1H,CH),4.48(s,1H,OH),3.55~3.42(m ,6H,CH and CH 2 ), 3.34(d, J=6.8Hz, 1H, CH), 2.95~2.73(m, 2H, CH 2 ), 2.32(t, J=7.7Hz, 4H, CH 2 ), 2.01(t, J=5.4Hz, 1H, CH), 1.79~1.21(m, 15H, CH and CH 2 ),1.14(dd,J 1 =7.1Hz,J 2 =7.9Hz,1H,CH),0.84(s,3H,CH 3 ),0.81(s,3H,CH 3 ).ESI-MS:687.9[M+H] + .Anal.Calcd for C 40 h 51 FN 4 o 5 :C,H,N.
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