Automatic electric-control gravity-type striker for constructing acute spinal cord injury animal model

Abstract

The invention discloses an automatic electric-control gravity-type striker for constructing an acute spinal cord injury animal model, which is characterized in that the striker comprises a base, a support, a transverse beam, an electromagnetic striker and a control box used for controlling the electromagnetic striker to act; the support is vertically arranged on the base, a vertical guide rail is arranged on the support, the transverse beam is arranged on the vertical guide rail, and a transverse beam height adjusting mechanism which is used for driving the transverse beam to slide on the guide rail and locking the transverse beam on the guide rail is arranged on the transverse beam; and the electromagnetic striker is fixed at one end of the transverse beam. The automatic electric-control gravity-type striker for constructing the acute spinal cord injury animal model has the advantages that the operability is high and the secondary strike can be effectively avoided.

Description

technical field [0001] The invention relates to an automatic electric control gravity type acute spinal cord injury animal model modeling striker. Background technique [0002] Spinal cord injury (spinal cord injury, SCI) is a serious trauma, and its incidence is increasing year by year. The treatment and rehabilitation of spinal cord injury is a major problem in today's medical field, because the pathophysiological mechanism after SCI is very complicated, and its Understanding is not enough. In order to better study the mechanism and pathological changes of spinal cord injury and provide evidence for effective treatment, it is of great significance to establish a standard and ideal experimental model. [0003] Clinical similarity, controllability, and reproducibility are often used as criteria for an ideal SCI animal model. There are many models of spinal cord injury, including spinal cord impingement model, spinal cord compression model, spinal cord traction model, spina...

AI Technical Summary

Problems solved by technology

There are many defects in this method: the most serious technical problem is that the time when the falling weight hits the spinal cord is often inconsistent; the instability of the spine and spinal cord and the lateral deviation of the spinal cord lead to asymmetrical SCI and the inconstant size of the injured area; The spinal cord is not removed in time after the object falls, resulting in different degrees of spinal cord compression injury, and the second or even multiple blows are caused by the rebound after the fall; the degree and duration of paralysis of animals are quite different

Due to the lack of specific striking equipment, the way of injury is relatively primitive and cannot be standardized

In 1995, Zhao Jianbin et al. designed a simple device for causing spinal cord injury in animals. In 1998, Tan Wei et al. reported the improvement and application of an experimental rabbit spinal cord injury striker. In 2003, Xu Xiaoqing et al. also developed a device for acute spinal cord injury. The percussion device established by the injury animal model, these percussion devices cannot solve the problem of the second strike, the percussion force is difficult to be constant, and the repeatability is poor

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