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Cynanchum bungei Decne extract, and preparation method and application thereof in blood sugar reduction

A technology of extract and Geshanxiao, which is applied in the field of medicine, can solve the problems of high toxicity and side effects, carcinogenicity, and easy damage to the liver

Active Publication Date: 2017-01-11
THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, the hypoglycemic effect of Western medicine is relatively obvious, and can effectively control blood sugar. However, long-term use has relatively serious side effects, such as sulfonylurea drugs, which are prone to liver and kidney damage, hypoglycemia, nausea, headache, dizziness, and blurred vision. , increase the side effects of cardiovascular disease mortality; biguanides are likely to cause nausea and increase the burden on the heart; thiazolidinediones are likely to damage the liver and cause cancer

Method used

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  • Cynanchum bungei Decne extract, and preparation method and application thereof in blood sugar reduction
  • Cynanchum bungei Decne extract, and preparation method and application thereof in blood sugar reduction
  • Cynanchum bungei Decne extract, and preparation method and application thereof in blood sugar reduction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A preparation method of Geshanxiao ethyl acetate extract, comprising the following steps:

[0019] Take Geshanxiao roots, wash them, dry them in the sun and grind them to 100 mesh fine powder. 1 kg of Geshanxiao root tuber powder, cold-soaked in 75% ethanol for 3 times each time for a week, concentrated under reduced pressure to remove ethanol to obtain extract, dissolved in 3-5 L of water, degreased by industrial petroleum ether, and then industrially distilled ethyl acetate 3-5 L of esters were extracted 3 times respectively, the ethyl acetate extracts were combined, and the ethyl acetate was removed by concentration under reduced pressure to obtain 48.6 g of Geshanxiao ethyl acetate extract, namely Geshanxiao extract.

Embodiment 2

[0021] A preparation method of Geshanxiao ethyl acetate extract, comprising the following steps:

[0022] Take Geshanxiao roots, wash them, dry them in the sun and grind them into fine powder of 120 mesh. Geshanxiao root tuber powder 1 kg, 75% ethanol heating reflux extraction 3 times for 2 hours each time, concentrated under reduced pressure to remove ethanol to obtain extract, add 3-5 L of water to dissolve the extract, degrease with industrial petroleum ether, and then industrial re-steam 3-5 L of ethyl acetate were extracted three times respectively, the ethyl acetate extracts were combined, and the ethyl acetate was removed by concentration under reduced pressure to obtain 52.1 g of Geshanxiao ethyl acetate extract, that is, Geshanxiao extract.

Embodiment 3

[0024] A preparation method of Geshanxiao ethyl acetate extract, comprising the following steps:

[0025] Take Geshanxiao roots and wash them, then dry them and grind them into fine powder of 110 mesh. Geshanxiao root tuber powder 1 kg, 95% ethanol heating reflux extraction 3 times for 2 hours each time, concentrated under reduced pressure to remove ethanol to obtain extract, add 3-5 L of water to dissolve the extract, degrease with industrial petroleum ether, and then industrial re-steam 3-5 L of ethyl acetate were extracted 3 times respectively, the ethyl acetate extracts were combined, and the ethyl acetate was removed by concentration under reduced pressure to obtain 38.6 g of Geshanxiao ethyl acetate extract, that is, Geshanxiao extract.

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Abstract

The invention discloses a Cynanchum bungei Decne extract, and a preparation method and application thereof in blood sugar reduction. The Cynanchum bungei Decne extract is an extract taking C21 steroid saponin and aglycone as main components, wherein the extract taking C21 steroid saponin and aglycone as main components is Caudatinin or Qingyangshengenin. The preparation method comprises the following steps: cleaning Cynanchum bungei Decne root tubers, drying in the sun, and pulverizing to obtain fine powder; performing cold soaking or heating reflux on the Cynanchum bungei Decne root tuber fine powder with organic solvent, and performing reduced-pressure concentration to remove the organic solvent so as to obtain an extractum; and dissolving the extractum with water to remove grease, then extracting with ethyl acetate, merging ethyl acetate extract liquids, and performing reduced-pressure concentration to remove the ethyl acetate so as to obtain a Cynanchum bungei Decne ethyl acetate extract, i.e. the Cynanchum bungei Decne extract. The Cynanchum bungei Decne extract disclosed by the invention can reduce blood sugar.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Geshanxiao extract, a preparation method of the Geshanxiao extract, and an application in lowering blood sugar. Background technique [0002] Diabetes is a common endocrine and metabolic disease with a high incidence rate. Its incidence rate is increasing year by year. It has become a common and frequently-occurring disease worldwide that endangers human health. It is listed as one of the three major diseases along with cardiovascular and cerebrovascular diseases and tumor diseases. one. The prevalence of diabetes is increasing year by year, and it is expected to increase to 380 million in 2025; the incidence of diabetes in China ranks first in the world, and about one tenth of the population suffers from hyperglycemia or diabetes. Type 1 diabetes is caused by congenital insulin deficiency; type 2 diabetes is caused by defects in insulin secretion and insulin resi...

Claims

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Application Information

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IPC IPC(8): A61K36/27A61P3/10
CPCA61K36/27A61K2236/55A61K2236/39A61K2236/333A61K2236/15
Inventor 黄烈军郝小江李玲顾玮苑春茂高丽辉
Owner THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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