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New use of isoliquiritigenin and derivative

A technology of isoliquiritigenin and new isoliquiritigenin, applied in medical preparations containing active ingredients, drug combinations, organic active ingredients, etc.

Inactive Publication Date: 2015-09-09
陈建萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, anti-tumor treatment studies have found that isoliquiritigenin has anti-tumor activity, but there are no reports on the effects of sensitization and drug resistance reduction when it is used with chemotherapy drugs

Method used

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  • New use of isoliquiritigenin and derivative
  • New use of isoliquiritigenin and derivative
  • New use of isoliquiritigenin and derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0133] Raw materials: isoliquiritigenin 50mg, paclitaxel 1.5mg

[0134] Preparation method: take the raw material drug in proportion, and prepare it into tablets according to the conventional preparation process.

Embodiment 2

[0136] Ingredients: Isoliquiritigenin 40mg, Adriamycin 3mg

[0137] Preparation method: Take the raw material drug in proportion, and prepare it into capsules according to the conventional preparation process.

Embodiment 3

[0139] Raw material: Isoliquiritigenin 60mg, 5-Fluorouracil 0.5mg

[0140] Preparation method: Take the raw material drug in proportion, and prepare injection according to the conventional preparation process.

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Abstract

The invention provides a new use of isoliquiritigenin and its derivative, and especially provides application of isoliquiritigenin, new isoliquiritigenin, natural plants containing isoliquiritigenin and its derivative or its extract in tumor resistance and synergists of chemotherapeutic drugs or drugs reducing the drug resistance of chemotherapeutic drugs.

Description

technical field [0001] The present invention relates to the new application of isoliquiritigenin and its derivatives, in particular to the application of isoliquiritigenin and its derivatives in anti-tumor and combined use with anti-tumor drugs to increase sensitivity and reduce drug resistance. Background technique [0002] Isoliquiritigenin is a flavonoid compound widely found in legumes. Modern pharmacological research shows that isoliquiritigenin has the functions of anti-tumor, anti-oxidation, anti-inflammation, and treatment of cardiovascular diseases. [0003] In recent years, anti-tumor treatment studies have found that isoliquiritigenin has anti-tumor activity, but there are no reports on the effects of sensitization and drug resistance reduction when it is used with chemotherapy drugs. Contents of the invention [0004] One object of the present invention is to provide the application of isoliquiritigenin and its derivatives in the preparation of antitumor drugs...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K31/7034A61P35/00
Inventor 陈建萍王志宇王能
Owner 陈建萍
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