Antipsychotic drug related metabolism syndrome susceptible gene and application thereof

A technology for antipsychotic drugs and metabolic syndrome, applied in the field of biotechnology and detection, can solve problems such as relapse and reduce drug treatment compliance

Active Publication Date: 2015-11-04
SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These adverse reactions are associated with potential long-term health risks for patients, reduced adherence to medication and, ultimately, possible relapse

Method used

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  • Antipsychotic drug related metabolism syndrome susceptible gene and application thereof
  • Antipsychotic drug related metabolism syndrome susceptible gene and application thereof
  • Antipsychotic drug related metabolism syndrome susceptible gene and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] Example 1 Evaluation of Clinical Samples

[0131] A total of 722 patients (401 males and 321 females) were enrolled. According to the DSM-IV diagnostic criteria, two senior physicians diagnosed and confirmed schizophrenia. They took atypical antipsychotics alone for more than one year (clozapine: 631 cases, olanzapine: 59 cases, risperidone: 32 cases), medical history and clinical data were collected, and the curative effect was evaluated by the Positive and Negative Syndrome Scale (PANSS). Blood was collected for metabolic index determination.

[0132] The definition of metabolic syndrome adopts the diagnostic criteria promulgated by the International Diabetes Federation (IDF) in 2005: central obesity (waist circumference ≥ 90 cm for Chinese men and ≥ 80 cm for women) plus any 2 of the following 4 factors, (1) triglycerides Elevated (TG) level: >1.7mmol / L (150mg / dL), or has been treated for this dyslipidemia. (2) Reduction of high-density lipoprotein cholesterol (HDL...

Embodiment 2

[0137] Example 2 Antipsychotic drug-associated metabolic syndrome susceptibility kit

[0138] Based on the correlation between the rs11654081-T allele of the SREBF1 gene and the metabolic syndrome associated with antipsychotic drugs, using SEQ ID NO.: 2, 3 (also can be designed separately) as primers, using the DNA of the patient's blood sample as a template Amplify and detect.

[0139] The prepared kit contains primers shown in SEQ ID NO.: 2 and 3, and a PCR reaction solution.

Embodiment 3

[0140] Example 3 Auxiliary Detection of Antipsychotic Drug-Related Metabolic Syndrome Susceptibility

[0141] Using the kit and general method in Example 2, 50 patients known to have antipsychotic drug-related metabolic syndrome in Example 1 and 50 samples without antipsychotic drug-related metabolic syndrome were collected. The two groups of samples were mixed, and using a random double-blind method, the presence of the SNP was detected in all samples, and the results were compared with samples known to have the disease.

[0142] The test results showed that there were 30 samples containing the SNP of the present invention, and 28 of them were from subjects suffering from antipsychotic drug-associated metabolic syndrome.

[0143] It can be seen that the SNP of the present invention has a very strong correlation with MetS, and the susceptibility to MetS can be effectively predicted and evaluated by using the SNP site.

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Abstract

The invention provides an antipsychotic drug related metabolism syndrome susceptible gene and an application thereof, and concretely relates to a use of a separate single-nucleotide polymorphism (SNP) site-containing polynucleotide or a detection reagent thereof in the preparation of kits for detecting antipsychotic drug related metabolism syndrome susceptibility. The SNP site in the polynucleotide corresponds to human chromosome 17p11.2 region (chr17:17708129(GRCh37/hg19)), rs11654081, C to T. The susceptibility of individuals to antipsychotic drug related metabolism syndrome can be judged in an adjuvant manner through detecting the gene and SNP, and a new approach is provided for diagnosis and corresponding treatment of the syndrome; and additionally, the discovery of the gene and the SNP also provides a new drug target for developing drugs for treating the related metabolism syndrome, and the gene and the SNP can be used as syndrome patient regression and prognosis molecule markers.

Description

technical field [0001] The invention belongs to the field of biotechnology and detection. Specifically, the invention relates to a method for detecting a marker SNP of susceptibility to antipsychotic drug-related metabolic syndrome and its application. Background technique [0002] Metabolic syndrome (MetS) is a group of risk factors for cardiovascular disease, including impaired glucose tolerance, diabetes, central obesity (abdominal obesity), abnormal lipid metabolism (elevated triglycerides, low-density lipoprotein cholesterol Elevated high-density lipoprotein cholesterol), high blood pressure. MetS, as an aggregate of multiple risk factors, has a higher risk of poor prognosis than those with only one risk factor, and its effect is not simply added, but synergistically aggravated, and the prevalence of cardiovascular events and strokes in patients with MetS and The risk of death is 2 to 3 times that of those without MetS. Combined with multiple cardiovascular risk facto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6883C12Q2600/106C12Q2600/156
Inventor 陈剑华徐一峰师咏勇杨琳李岩王琰梁世桥
Owner SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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