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A method for assessing hypersensitivity reactions to the antiepileptic drug phenytoin using hla alleles

An allele, phenytoin technology, applied in biochemical equipment and methods, microbial determination/inspection, etc., can solve problems such as unclear relationship

Active Publication Date: 2018-10-02
CHANG GUNG MEDICAL FOUND CHANG GUNG MEMORIAL HOSPITAL AT KEELUNG
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the relationship between drug metabolism / genetic susceptibility and anaphylaxis to phenytoin remains unclear

Method used

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  • A method for assessing hypersensitivity reactions to the antiepileptic drug phenytoin using hla alleles
  • A method for assessing hypersensitivity reactions to the antiepileptic drug phenytoin using hla alleles
  • A method for assessing hypersensitivity reactions to the antiepileptic drug phenytoin using hla alleles

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Embodiment Construction

[0011] The following detailed description is intended as a present exemplary description of aspects in accordance with the invention and is not intended to represent the only forms in which the invention may be made or utilized. It should be understood that the same or equivalent functions and elements that can be implemented in different embodiments also fall within the spirit and scope of the present invention.

[0012] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods, devices and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the exemplary methods, devices and materials are now described.

[0013] All publications mentioned are incorporated by reference for the purpose of describing and disclosing, for example, the designs and methodologies de...

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Abstract

Provided is a method for evaluating a drug anaphylactic reaction caused by antiepileptic drug phenytoin with HLA allele. The drug anaphylactic reaction comprises a Steven Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) or a drug reaction with eosinophiliaand systemic symptoms (DRESS). The gene polymorphism (including CYP2C9, CYP2C19, CYP2C8 and CYP2C18) of CYP2C genes, HLA gene types (including HLA-A*0207, HLA-A*2402, HLA-B*1301, HLA-B*1502, HLA-B*4001, HLA-B*4609, HLA-B*5101, HLA-DRB1*1001 and HLA-DRB1*1502) and the concentration of phenytoin in plasma of a patient all may cause phenytoin adverse drug reactions.

Description

[0001] The present invention is a divisional application of a patent application with an application date of December 19, 2013, an application number of 201180071752.1, and an invention title of "Method for Evaluating the Risk of Adverse Drug Reactions Caused by Antiepileptic Drug Phenytoin". technical field [0002] The invention relates to a method for predicting the risk of a patient's adverse drug reaction, especially the risk assessment of the allergic reaction caused by the antiepileptic drug phenytoin. Background technique [0003] Adverse drug reactions (ADRs for short) are manifestations of harm caused by the use of drugs at normal doses. Drug allergic reaction is a common adverse reaction in drug therapy and accounts for about 20% of reported adverse drug reaction cases. These reactions can range from mild erythematous eruption (MPE) to life-threatening drug rash with eosinophilia and systemic symptoms (DRESS), Stevenson-Johnson syndrome (SJS) and toxic epidermal n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/106C12Q2600/118C12Q2600/156C12Q2600/172
Inventor 钟文宏洪舜郁
Owner CHANG GUNG MEDICAL FOUND CHANG GUNG MEMORIAL HOSPITAL AT KEELUNG
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