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33 results about "Drug rash" patented technology

Pulsatile release compositions of milnacipran

InactiveUS20060003004A1Minimize exposureReduces milnacipran gastrointestinal side effectCapsule deliveryCoatingsPalpitationsPanic
A once-a-day oral milnacipran pulsatile release composition has been developed that releases the drug in spaced apart “pulses”. The dosage forms are comprised of first, second and optional third dosage units, with each dosage unit having a different drug release profile. This dosage form provides in vivo drug plasma levels characterized by Cmax below 3000 ng / ml, preferably below 2000 ng / ml, and most preferably below 1000 ng / ml. The composition provides pulsatile release of milnacipran to produce a therapeutic effect over approximately 24 hours, when administered to a patient in need, resulting in diminished incidence or decreased intensity of common milnacipran side effects such as sleep disturbance, nausea, vomiting, headache, tremulousness, anxiety, panic attacks, palpitations, urinary retention, orthostatic hypotension, diaphoresis, chest pain, rash, weight gain, back pain, constipation, vertigo, increased sweating, agitation, hot flushes, tremors, fatigue, somnolence, dyspepsia, dysoria, nervousness, dry mouth, abdominal pain, irritability, and insomnia.
Owner:COLLEGIUM PHARMA INC

Human leukocyte antigen gene detection kit for screening clindamycin-induced adverse drug reactions on skin

The invention belongs to the technical field of biological medicine, and relates to a human leukocyte antigen HLA-B*51: 01 gene detection kit. An HLA-B*51: 01 gene can be used as a marker gene for predicting clindamycin-induced drug rash. The invention provides the application of the detection kit to typing of the HLA-B*51: 01 gene in a sample. The application comprises the following steps: extracting DNA from obtained peripheral blood of a patient, and detecting the HLA-B*51: 01 gene by a current method, such as a sequence-specific oligonucleotide probe (PCR-SSO) method. The HLA-B*51: 01 gene detection kit provided by the invention can be applied to screening and sifting of targeted drugs for treating the clindamycin-induced drug rash before the use of clindamycin; screening application can guide clinical drug use so as to reduce incidence of the clindamycin-induced drug rash; selecting application mainly acts on an HLA-B*51: 01 molecule in a targeted manner so as to block interaction between the HLA-B*51: 01 molecule and clindamycin or other metabolites during the drug rash.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV +1

Traditional Chinese medicine composition for externally applying to treat benign prostatic hyperplasia

The invention relates to a traditional Chinese medicine composition for externally applying to treat benign prostatic hyperplasia. The traditional Chinese medicine composition is prepared from the following medicinal raw materials by weight: 450-550g of angelica sinensis, 450-550g of sichuan lovage rhizome, 450-550g of flos carthami, 450-550g of peach kernels, 450-550g of astragalus membranaceus, 450-550g of salviae miltiorrhizae, 450-550g of curcuma aromatica, 450-550g of cortex moutan and 450-550g of honeysuckle. The traditional Chinese medicine composition provided by the invention is suitable for crowds of all age groups and free of any influence on crowds with background diseases. Although the traditional Chinese medicine composition is prepared from common traditional Chinese medicines, the effect is still remarkable if the traditional Chinese medicine composition is used in an insisted manner. Under the joint effect with infrared rays, the efficacy is absorbed by virtue of skin vessels and the composition can be directly acted on the prostate. The most major advantage of the traditional Chinese medicine composition is to reduce adverse reactions caused by long-term administration of the patient. Except for a small part of patients with rash itch, no other obvious side effects are available, and the clinical follow-up survey effective rate is over 98%.
Owner:界首骨科医院

Drug rash plasma exosome circRNA marker and detection primer kit thereof

The invention discloses a drug rash plasma exosome circRNA marker. The drug rash plasma exosome circRNA marker comprises a primer and a probe of a combination of a drug rash plasma exosome long RNA marker and a miRNA marker; the long RNA marker comprises one or more of circ_0047921, hsa_circ_0006773 or circ_0056285; and the miRNA marker comprises one or more of miR-375-3p, miR-200a-3p, miR-122-5p and miR-27a-3p. The invention provides the drug rash plasma exosome circRNA marker; after clinical verification, the drug rash plasma exosome circRNA marker has relatively high specificity and sensitive value, and has relatively high diagnostic reference value; by analyzing the expression condition of the circRNA in the plasma exosome, whether a subject suffers from drug rash or not can be accurately judged with a large probability; a basis is provided for early discovery of diseases; opportunities are provided for early treatment of patients; the diagnosis accuracy is improved; the diagnosis process is simplified, and the invention has a large application prospect.
Owner:AIR FORCE MEDICAL UNIV

Drug rash patient management system and nursing scheme generation method

The invention discloses a drug rash patient management system, and the system comprises an information management system, an information acquisition system, an information storage unit and a display device. The information management system is used for uniformly deploying the information acquisition system, the information storage unit and the display device, and is used for calculating and processing each piece of information; the information acquisition system comprises an image acquisition unit and a character input unit, the character input unit inputs information of a patient, and an image system acquires two-dimensional code or rash image information; and the information storage unit is used for storing various information of the patient. According to the method for generating the nursing scheme for the patient with the drug rash, different nursing schemes are automatically generated, and various information of the patient is considered, so that exclusive nursing schemes can be generated according to different patients, the later nursing effect is better, and the time consumed by automatically generating the nursing schemes is shorter, so that medical staff can obtain a nursing scheme more quickly, and a large amount of time is saved.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV

Medicine rash plasma exosome protein and kit thereof

The invention provides a medicine rash plasma exosome protein and a kit thereof, and relates to the technical field of kits. According to the kit for the medicine rash plasma exosome protein, a box body and a box cover, a limiting plate is fixedly arranged in the box body, a plurality of containing through grooves are formed in the limiting plate, positioning assemblies are arranged in the containing through grooves, a bearing plate is arranged at the bottom of the limiting plate, and bearing mechanisms are fixedly arranged at the positions, corresponding to the containing through grooves, of the bearing plate; the bearing mechanism comprises a fixing cylinder, a positioning assembly is also arranged in the fixing cylinder, and buffering sets are arranged at the positions, corresponding to the containing through grooves, of the box cover. According to the kit for the medicine rash plasma exosome protein, vibration energy from reagent bottles is absorbed through a plurality of elastic strips in the two positioning assemblies and a buffer assembly arranged at the bottom of the box cover in a matched mode, so that the reagent bottles are stably and neatly located in the box body, and the possibility that reagent liquid in the reagent bottles generates foam due to shaking is reduced.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Traditional Chinese medicine nursing agent for treating rash caused by hand-foot-and-mouth disease

A traditional Chinese medicine nursing agent for treating rash caused by hand-foot-and-mouth disease is prepared from raw materials in parts by weight as follows: 5-9 parts of amur cork-tree, 7-12 parts of purslane herb, 4-9 parts of grassleaf sweetflag rhizome, 15-20 parts of Tokyo violet herb, 3-4 parts of natural indigo, 5-8 parts of largeleaf gentian root, 12-15 parts of kudzuvine root, 10-16 parts of honeysuckle flower, 3-8 parts of creeping euphorbia, 5-12 parts of dandelion, 12-17 parts of common bombax flower, 4-6 parts of mint, 8-12 parts of honeysuckle stem, 3-4 parts of dwarf lilyturf tuber, 12-15 parts of fragrant solomonseal rhizome, 10-15 parts of divaricate saposhnikovia root, 8-12 parts of beautiful sweetgum fruit, 2-5 parts of Chinese gall, 3-7 parts of cape jasmine fruit, 11-14 parts of smoked plum, 9-15 parts of officinal magnolia bark, 3-6 parts of tribulus terrestris fruit, 8-13 parts of atractylodes rhizome, 3-5 parts of dendrobium stem, 1-3 parts of Gromwell root, 5-10 parts of climbing groundsel herb and 5-10 parts of common cnidium fruit.
Owner:QINGDAO MUNICIPAL HOSPITAL

Externally applied medicine for treating eczematous dermatitis as well as preparation method and application thereof

The invention relates to the field of medicines, and particularly discloses an externally applied medicine for treating eczematous dermatitis and a preparation method and application thereof. Raw materials of the medicine comprise lithospermum, divaricate saposhnikovia root, Chinese angelica, radix angelicae, radix rehmanniae recens, honeysuckle buds and flowers and scutellaria baicalensis. The externally applied medicine for treating eczematous dermatitis is effective on eczematous dermatitis, has effects on related diseases such as drug rash, neurodermatitis and mosquito bite swelling, and can be directly smeared on an affected part due to the adoption of a pure traditional Chinese medicine formula. The medicine is free of side effects caused by hormone ointment such as hyperpigmentation, coarse pores and induction of other diseases, has the advantages of being easy to prepare, convenient to use, stable in medicine effect, safe and free of stimulation. The preparation method is simple, and the medicine is free of side effects, and solves the problems that most of existing medicines for treating eczema are western medicines which has many side effects, and the medicine has a wide market prospect.
Owner:浙江中医药大学附属第二医院
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