34 results about "Drug rash" patented technology

The invention relates to the field of biomedicine, and discloses application of an HLA-B * 27: 04 allele in preparation of a product for evaluating the risk of drug rash caused by hydroxychloroquine. The application comprises the step of predicting the medication risk of a subject by detecting whether the subject carries the HLA-B * 27: 04 allele or not. The HLA-B * 27: 04 allele is found to be strongly related to the drug rash caused by the hydroxychloroquine for the first time and can be used as a risk genetic marker of the drug rash caused by the hydroxychloroquine. In practical application, the risk of drug eruption of a subject needing to be treated by using hydroxychloroquine can be predicted by detecting whether the HLA-B * 27: 04 allele is carried by the subject, and the risk of drug eruption caused by hydroxychloroquine of the subject carrying the HLA-B * 27: 04 allele after the subject uses hydroxychloroquine is obviously higher than that of a non-carrier. The detection product provided by the invention is high in specificity, high in positive predictive value and good in clinical application prospect.