Application of dendrophenol and composition thereof in preparation of medicine for treating allergic dermatosis

A technology of dendrobium and allergies, applied in the field of application of dendrobium in the preparation of drugs for the treatment of allergic skin diseases, can solve the problems that have not yet been reported on drugs for allergic skin diseases, and achieve the reduction of the number of eosinophils and mast cells , reduce the skin lesion score, the effect of clear ingredients

Active Publication Date: 2022-06-24
HEFEI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there has been no relevant report on using dendrobium as a drug for the treatment of allergic skin diseases

Method used

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  • Application of dendrophenol and composition thereof in preparation of medicine for treating allergic dermatosis
  • Application of dendrophenol and composition thereof in preparation of medicine for treating allergic dermatosis
  • Application of dendrophenol and composition thereof in preparation of medicine for treating allergic dermatosis

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Example 1: The effect of dendrobium on the guinea pig model of allergic skin disease.

[0029] 1. Experimental animals: guinea pigs, weighing 220-250g, provided by Laifu Farm, Pukou District, Nanjing, animal production license number: SCXK (Su) 2019-0005, half male and half male.

[0030] 2. Drug preparation: Dendrobium phenol (0.25g), stearic acid (0.55g), potassium carbonate (0.045g), glycerin (0.5g), glyceryl monostearate (0.125g), triethanolamine (0.015mL) , clove oil (0.035mL) to prepare dendrobium phenol emulsifiable paste. The emulsification temperature is 70°C, and the dosage is 2.5g / kg / time.

[0031] experimental method:

[0032] (1) Modeling: After the animals have adapted to the environment for 1 week, the allergic skin disease model was replicated by 1-chloro-2,4-dinitrobenzene (DNCB) induction method, and the guinea pigs were shaved on both sides of the back one day before the experiment , with an area of ​​about 2cm×2cm, the shaved area was sensitized w...

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Abstract

The invention discloses application of dendrophenol and a composition thereof in preparation of drugs for treating allergic dermatosis, and belongs to the technical field of new medical application of active component dendrophenol of traditional Chinese medicinal materials. In particular to application of dendrophenol in preparation of drugs for treating allergic skin diseases, and the allergic skin diseases comprise urticaria, eczema, contact dermatitis, atopic dermatitis, anaphylactoid purpura and drug rash. Animal test results show that the dendrophenol can inhibit inflammatory response, ear swelling and scratching times of a guinea pig allergic skin disease model induced by 2, 4-dinitrochlorobenzene, and reduce infiltration of eosinophilic granulocytes and mast cells at an affected part, so that the dendrophenol has the effects of resisting allergic reaction, diminishing swelling and relieving itching, and has a very good treatment effect on allergic skin diseases.

Description

technical field [0001] The invention belongs to the technical field of new medical applications of dendrobium phenol, an active ingredient of Chinese medicinal materials, and specifically relates to the application of dendrobium phenol in the preparation of medicines for treating allergic skin diseases, such as urticaria, eczema, contact dermatitis, Atopic dermatitis, atopic purpura, and drug eruptions. Background technique [0002] Allergic skin disease is one of the most common allergic diseases. It is mainly caused by a variety of skin symptoms caused by type I allergy, specifically manifested as a variety of dermatitis, eczema, and urticaria. Various allergens can cause skin capillaries to dilate, enhance permeability, infiltrate inflammatory cells, release a variety of allergic mediators, and stimulate peripheral nerve cells, resulting in skin rashes and ulcers. Allergic skin diseases are easy to recur, and the affected area often shows severe itching, which seriously ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09A61K47/44A61P37/08A61P17/00A61P7/04
CPCA61K31/09A61K47/44A61P37/08A61P17/00A61P7/04Y02A50/30
Inventor 王伟张扬陈爽爽汪义媛李育鹏胡润凡陈杜艳李锦骁
Owner HEFEI NORMAL UNIV
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