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Application of fraxinellone in preparation of drugs for treating allergic skin diseases

A technology for allergies and skin diseases, applied in allergic diseases, skin diseases, drug combinations, etc., can solve the problems of patients with ineffectiveness, easy recurrence, and many adverse reactions

Inactive Publication Date: 2021-10-01
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs are aimed at different links of allergic reactions, with clear curative effects and rapid onset of effects, but they are ineffective for some patients, easy to relapse after drug withdrawal, and have many adverse reactions, such as drowsiness, dry mouth, dizziness and other problems
[0005] Compared with the high incidence of allergic skin diseases, existing drugs can not meet the clinical needs, it is necessary to discover and develop new anti-allergic drugs

Method used

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  • Application of fraxinellone in preparation of drugs for treating allergic skin diseases
  • Application of fraxinellone in preparation of drugs for treating allergic skin diseases
  • Application of fraxinellone in preparation of drugs for treating allergic skin diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Passive skin allergy test (PCA)

[0027] Sensitization: SD rats, weighing 200-250 g, both male and female, provided by the Guangdong Experimental Animal Center. Take 10 SD rats, and inject 1 mL of physiological saline solution containing 1 mg ovalbumin and 10 mg aluminum hydroxide intraperitoneally into each SD rat for immunization; once every other day, a total of 3 times, they were killed 12 days after the last sensitization, and the abdominal aorta Blood collection, 3000r·min -1 Centrifuge for 10 min, take the supernatant, prepare antiserum, and store it at -20°C for future use.

[0028] Passive sensitization: BALB / c mice, half male and half male, 18-22 g, SPF grade, purchased from Zhejiang Weitong Lihua Experimental Animal Technology Co., Ltd. Sixty Balb / c mice were randomly divided into normal group, model group, loratadine group, low-dose alkone group, middle-dose alkone group, and high-dose alkone group.

[0029] The low-, medium-, and high-dose groups were ad...

Embodiment 2

[0062] Tablets containing arketone

[0063] Formula: alkone 200g, lactose 88g, hydroxymethyl starch sodium 9g, magnesium stearate 3g.

[0064] Preparation method: take the alkone raw material drug, lactose and sodium hydroxymethyl starch (75% of the formula amount) according to the formula and mix them, pass through a 120-mesh sieve for 3 times, and mix well. Add an appropriate amount of binder to make a soft material. The soft material is passed through a 18-mesh sieve, and the wet granules are dried in an oven at 50°C for 1 hour. Formula quantity), mix well, compress into tablets, and get ready.

Embodiment 3

[0066] Capsules containing arketone

[0067] Recipe: alkone 180g, starch 50g, dextrin 50g.

[0068] Preparation method: Weigh alkone raw material, add starch and dextrin, mix well, use 90% ethanol as wetting agent for wet granulation, vacuum dry at 50°C and then granulate, pass through 40-mesh sieve and 200-mesh sieve The fine powder is removed, and the medicinal powder granules are packed into No. 3 capsules in an environment with a humidity lower than 60%.

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Abstract

The invention discloses an application of fraxinellone in preparation of drugs for treating allergic skin diseases. The allergic skin diseases comprise urticaria, eczema, contact dermatitis, atopic dermatitis, anaphylactoid purpura and drug rash. According to the invention, fraxinellone is used for treating immune globulin E (IgE)-mediated skin diseases for the first time, and fraxinellone can promote Th1 type cells to generate IFN-gamma. 25 mg / kg of fraxinellone is given to mice with passive skin allergy, degranulation of skin tissue mast cells is inhibited, and the inhibition rate reaches 34.01%. 50 mg / kg of fraxinellone is given to mice with passive skin allergy, and the degranulation inhibition rate of skin mast cells reaches 54.34%. 100 mg / kg of fraxinellone is given to mice with passive skin allergy, and the degranulation inhibition rate of skin mast cells reaches 62.5%.

Description

technical field [0001] The invention belongs to the field of dermatological medicines, and in particular relates to the application of arketone in the preparation of medicines for treating allergic skin diseases. Background technique [0002] Allergic diseases mainly include allergic skin diseases, allergic respiratory diseases, allergic gastrointestinal diseases, etc., which are common clinical diseases and frequently-occurring diseases. [0003] Allergic skin diseases account for a large proportion of skin diseases. Allergens enter the human body through various channels, and after combining with antibodies in the body, sensitization occurs, forming immune complexes, stimulating mast cells to degranulate, releasing histamine, white three ene and other transmitters, thereby inducing IgE-mediated type I allergic reaction, resulting in skin redness, swelling, ulceration, itching, etc., which affect the appearance and lead to low self-esteem of the patient, seriously affecting...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P17/00A61P37/08
CPCA61K31/365A61P17/00A61P37/08
Inventor 卢传坚赵瑞芝刘丽娟吴亚运赵亚
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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