114 results about "Cutaneous allergy" patented technology

The present invention discloses a protease super-concentrated laundry detergent, which mainly comprises, by mass, 3-38% of a non-ionic surfactant, 1-22% of an anionic surfactant, 0.1-1% of protease, 0.1-2% of triethanolamine, 0.1-2% of sodium citrate, 0.1-2% of refined salt and 60-70% of deionized water, wherein the protease comprises biological protease and compound protease. According to the present invention, the protease super-concentrated laundry detergent product is neutral and has characteristics of mild nature, no stimulation, soft hand-feeling, no alkaline residue after washing, no skin allergy and other symptoms, no damage on fabrics, water solubility, easy use, easy use amount control, easy storage, and easy use; and the process operation of the preparation method is simple, and the method is easily subjected to industrial production.

The invention discloses an anti-allergic restoring facial mask which comprises the following components: water, dipropylene glycol, glycerin, methyl propanediol, SC-glucan, Shuminjia, an olea europaea fruit extract, a milk skin conditioner, allantoin, sodium hyaluronate, biosaccharide gum-1, PEG-40 hydrogenated castor oil, disodium EDTA, a GPL preservative, methylparaben and essences. The raw materials used in the invention have mild nature, no irritation, no toxic and side effects, and significant effects of relieving sensitivity, diminishing inflammation and sterilizing, astringing and restoring skin, activating skin cells, enhancing skin resistance and restoring physiological functions of the skin, can rapidly relieve swelling and pain caused by skin allergy, astringe and restore sensitive and damaged cells, deeply penetrate the skin, continuously replenish nutrients and moisture of the skin, lock water and keep moisture for long term, play a nourishing role while supplementing water, and achieve a long-term skin beautifying effect.

Pharmacological test shows that the externally-used preparation of Cetirizine has ideal allergy resistant and anti-inflammatory action to the rat passive cutaneous anaphylaxis (Rat PCA) model and dimethylbenzene caused mouse otitis model, and also prevents the adverse effect to the central system caused by whole body administration. It is also found in the test, that the externally used preparation of Cetirizine also has very fine inhibitory action to dinitrofluorobenzene caused mouse porphyria hypersensitivity (PTH), the novel pharmacological action of the Cetirizine shows that the Cetirizine external preparation has good therapeutic action to skin inflammations which mainly include porphyria hypersensitivity.

The invention discloses daily restoration-type essence. The daily restoration-type essence is prepared from the following components in parts by weight: 2 to 6 parts of human-like collagen, 3 to 8 parts of oligopeptides, 0.1 to 0.2 part of aloe powder, 0.1 to 0.2 part of hyaluronic acid, 3 to 10 parts of glycerinum, 0.5 to 1.5 parts of propanediol, 1 to 5 parts of 1,3-butanediol, 0.2 to 0.4 part of phenoxyethanol, 0.05 to 0.08 part of ethylhexylglycerin and 75 to 90 parts of water. According to the daily restoration-type essence, main functional ingredients of the essence comprise human-like collagen, oligopeptides and aloe powder, the human-like collagen and the oligopeptides can accelerate the restoration of histocyte, improve the skin elasticity, supplement the water, maintain the moisture and keep the skin health; and the aloe can play an antibacterial anti-inflammation effect and has a certain curative effect on skin allergy. All components used by the essence provided by the invention are safe and reliable, and the skin is not damaged.

The invention discloses a Chinese traditional medicine composition used for itch relieving, which is characterized in that the components of the composition are extracts of the raw materials with weight shares as follows: 15-25 shares of sophora Flavescens Ait, 15-25 shares of purslane, 10-20 shares of liquorice, 5-15 shares of radix saposhnikoviae, 15-20 shares of tribulus fruit, 5-15 shares of broom cypress fruit and 5-15 shares of Fructus Cnidii. The invention also discloses a preparation method and purposes of the Chinese traditional medicine composition. The Chinese traditional medicine composition of the invention is suitable for all kinds of cutaneous pruritus and has certain releasing action on other symptoms resulted from skin allergy.

The invention provides gene sequences of wild type, S252W mutant type and P253R mutant type FGFR2b ectodomains and polypeptides coded thereby respectively. A preparation system of the polypeptide comprises a recombinant vector, a host cell and a preparation method, an antibody of FGFR2b ectodomain and a preparation method thereof as well as a fusion polypeptide, an antagonist and the like of the FGFR2B ectodomain and Fc domain. The invention also provides an application of the polypeptide of FGFR2b ectodomain and a composition in treating eczema, acne, psoriasis, skin allergy, seborrheic dermatitis or alopecia seborrheica; an FGF signal channel is inhibited through the FGFR2b ectodomain, the symptoms such as swelling, pruritus and the like of inflammatory skin diseases are inhibited, and an inhibitory effect is also realized on the sebum secretion.

The present invention discloses a composition for rapid allergy-relieving and repairing, and a preparation method and a use of the composition. The composition comprises beta-glucan, tamarindus indicaseed polysaccharides, a pogostemon cablin leaf extract, silanediol salicylate, a rhodiola rosea root extract, lactobacillus fermentation lysate, etc. The composition also contains glycerin, 1,3-butanediol, acrylic acid and ester copolymers, hydroxyethyl acrylate, disodium EDTA, arginine, polysorbate-20, dipotassium glycyrrhizinate, phenoxyethanol and water. The present invention also provides thepreparation method and use of the composition. The provided composition for rapid allergy-relieving and repairing can quickly alleviate symptoms of skin allergy or skin allergy injury, etc. caused bydifferent reasons, can rapidly relieve sensitive skin symptoms, and can also alleviate the skin allergy from fundamental factors.

The invention discloses a composite coating liquid of fibroin and a preparation method and an application thereof. The composite coating liquid of fibroin is composed of the following components: 2 to 10 wt percent of crosslinking agent, 0.5 to 2 wt percent of acetate acid, 10 to 20 percent of fibroin and water which accounts for the rest weight proportion. The preparation method of the invention comprises the steps of (1) the preparation of the fibroin and (2) the preparation of the composite coating liquid of fibroin. The fibroin of the invention has the functions of naturally moisturizing the skin, antisepsis, antianaphylaxis, etc. and is applicable to the preparation of lotions for women, infants or children; thus achieving the purposes of moistening the skin, absorbing moisture, resisting bacteria and treating and preventing skin allergy; the product prepared by the invention has significant functions of moistening the skin, absorbing moisture, venting, preventing skin allergy and inhibiting bacteria, especially has remarkable inhibited effect on pathogenic anaerobion and acid-producing bacteria.

The invention provides an externally-applied traditional Chinese medicinal preparation for treating skin allergy and pruritus, and a preparation method thereof. The preparation method comprises the following steps: respectively cleaning Rhizoma Coptidis, Amur Corktree Bark, Sophora flavescens, Cortex Dictamni, Fructus Kochiae, Polygonatum sibiricum, camphor, borax, Natural Indigo, honeysuckle flower and Weeping Forsythia, airing, drying, disinfecting, grinding to form fine powder, sieving by a 120 mesh sieve, crushing menthol and borneol to 120 mesh powder, mixing the above powders, adding clove oil, camphor oil and Vaseline, blending for 30min, taking out, loading, and filing to a box. The externally-applied traditional Chinese medicinal preparation is developed through combining the modern medicinal research achievement with the traditional Chinese medicinal clinic experience according to the traditional Chinese medicinal theories. The medicines selected by the externally-applied traditional Chinese medicinal preparation are pure Chinese herbal medicines, and the externally-applied traditional Chinese medicinal preparation has the advantages of reasonable synergistic compatibility, rapid and direct action on the affected parts, avoiding of the stimulation of an oral preparation to the stomach, intestine, liver and kidney, reduction of the pains of a patient, short treatment course, low cost, use convenience, rapid disappearance of clinic symptoms, substantial curative effect, practicality, convenience, safety and no toxic side effects.

The invention discloses an extract of a traditional Chinese medicine composite with an anti-allergy effect. The traditional Chinese medicine composite comprises the following traditional Chinese medicine components by weight percentage: 10-40% of cortex dictamni, 5-30% of lithospermum erythrorhizon, 5-30% of radix saposhnikoviae, 5-30% of Chinese angelica, 5-20% of radix polygonati officinalis, and 5-25% of liquorice. After the traditional Chinese medicine composite is subjected to heating and reflux extraction, an extracting solution is condensed and then passes through a macroporous resin column; elution is performed by an alcohol solution; an eluant is depressurized and condensed; dilution is performed by butanediol; and then the extract of the traditional Chinese medicine composite is obtained. The extract of the traditional Chinese medicine composite has good functions of restraining skin allergy and relieving skin itching, and can be applied to external skin agents such as cosmetics.

The present invention relates to methods of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cell. In particular, diseases or disorders including contact dermatitis, drug induced delayed type cutaneous allergic reactions, toxic epidermal necrolysis, cutaneous T cell lymphoma, bullous pemphigoid, alopecia aereata, vitiligo, acne rosacea, prurigo nodularis, and herpes simplex virus, or combination thereof will benefit from the administration of an IL-31 antagonist. The invention also includes methods of predicting a therapeutically responsive patient population.

The invention provides a pharmaceutical composition with medicament compatibility of astragali roots, forsythia fruits, mume fruits, licorice and the like. The composition has good treatment effects for allergic rhinitis and skin allergy. The invention provides a product of the traditional Chinese medicine composition as well as applications thereof to the fields of medicines and foodstuffs.

The invention provides a reagent composition for skin care. The reagent composition comprises a first reagent, a second reagent and a third reagent, wherein the first reagent comprises glycerin, butanediol and sodium hyaluronate; the second reagent comprises tranexamic acid, ascorbic acid and dipotassium glycyrrhizinate; and the third reagent comprises an umbilical cord mesenchymal stem cell exosome extract. The reagent composition for skin care has better wrinkle removal and anti-allergic effects and better absorbability, and can better improve the skin state after being used by a wrinkled person or a person with skin allergy.

The invention belongs to the technical field of traditional Chinese medicine beautifying and relates to traditional Chinese medicine detoxifying and acne removing mask powder and a preparation methodthereof. The traditional Chinese medicine detoxifying and acne removing mask powder prepared from pure traditional Chinese medicine components is capable of preventing decrustation and redness and swelling, free of harmful chemical substances and hormone components, free of side effects, capable of avoiding scars, capable of avoiding relapse, capable of clearing heat and purging fire, promoting blood circulation and diminishing inflammation, detoxifying and removing acne and whitening and rejuvenating the skin, and applicable to acne, furunculosis, skin allergy, cosmetic allergy and the like.

The invention relates to a medicine for treating various arthralgia, tumidness, inflexibility, motion difficulty and other diseases caused by wind, cold and wet, in particular to wind-damp expelling traditional Chinese medicine powder. The wind-damp expelling traditional Chinese medicine powder is prepared by the following medicine drugs by part of weight in normal-temperature grinding mode: 15-25 parts of lycopodium clavatum, 10-20 parts of pawpaw, 20-35 parts of drynaria rhizome, 15-30 parts pf garden balsam stems, 15-30 parts of fennel, 10-20 parts of erodium stephanianum willd, 20-30 parts of carthamus tinctorius, 10-15 parts of medlar, 10-15 parts of cornu cervi degelatinatum and 10-20 parts of elecampane. The traditional Chinese medicine powder has the function of expelling wind and removing cold, removing dampness, promoting blood circulation and removing meridian obstruction, and is capable of treating both principal and secondary aspect of the disease, capable of fast relieving pain, capable of invigorating body health to eventually eradicating pain, and capable of having the function of preventing wind cold and wet heat from invading the body after long-time use. The traditional Chinese medicine powder is in the type of powder, can be massaged to permeate into the skin to be absorbed in terms of the ill positions, has permeability on the skin, causes small skin allergy, and can directly act on the ill position to rapidly remit the pain.

The invention provides an extraction method for oat total alkaloid. The method comprises the following operation steps that oat bran and C3-C4 saturated binary fatty alcohol are mixed according to thematerial-liquid mass ratio of the oat bran to the C3-C4 saturated binary fatty alcohol of 1:(10-25), subjected to heat preservation stirring at 55-70 DEG C for 3-6 hours and filtered when the mixtureis hot, and the oat total alkaloid is obtained. The C3-C4 saturated binary fatty alcohol is selected from one or more of 1,2-propylene glycol, 1,3-propylene glycol and 1,3-butanediol. The invention further provides application of the oat total alkaloid prepared through the extraction method in skin allergy resistance. The preparation method of the oat total alkaloid is low in cost, high in extraction efficiency, easy and convenient to implement and particularly suitable for industrial production.

The invention provides an osthole-mixing ointment, and the active components in the formula comprise osthole and ligustrazine. The ointment has a stronger inhibition effect on skin allergy, overcomes the problem of patient skin allergy directly existed in some other antiphlogistic analgesic medicines, and has a good application prospect in anti-inflammation, analgesia and eczema treatment.

The invention relates to a transdermal patch (or poultice) with functions of expelling wind and removing dampness and reducing swelling and easing pain and a preparation method thereof; the transdermal patch is composed of a backlining layer, a medicine storage layer and an anti-sticking layer; the medicine storage layer comprises the following ingredients: 20-30 percent of framework material, 22-32 percent of tackifier, 25-35 percent of stuffing bulking agent, 6-13 percent of lubricating agent, and 6-13 percent of medicine, the medicine mainly comprises more than 30 kinds of extract prepared by traditional Chinese medicines, such as suberect spatholobus stem, spathodea campanulata, schefflerakwangsiensis, climbing entada, Ilex godajam dry skin, fissistigma polyanthum and the like, the medicines are pasted to obtain tongzhongling transdermal patch the according to the process steps and the mixing proportion; as no solvent is used in the production, the production cost is reduced by 1 / 3, the pesticide effect is improved, the drug administration times are reduced, the usage is convenient, cutaneous anaphylaxis is reduced, and the compliance of patients is improved; the tongzhongling transdermal patch has the effect of expelling wind and removing dampness and reducing swelling and easing pain and is clinically used for rheumatoid arthritis and traumatic injury.

The invention discloses an external liniment with a function of improving allergy. The external liniment comprises the following components in percentage by mass: 65-74 percent of blackcurrant seed oil, 8-12 percent of gamma-linolenic acid, 8-12 percent of blackcurrant extracting solution, 2-4 percent of anthocyanin, 1-3 percent of vitamin C, 0.5-0.8 percent of zinc-containing compound, 1-3 percent of beeswax, 1-4 percent of lecithin and 0.2-0.5 percent of borneol, wherein the total mass percent of the components is 100 percent. According to the external liniment, decoction consisting of 20-30 parts of fructus forsythiae, 10-18 parts of cynanchum paniculatum, 6-8 parts of mint and 2-4 parts of liquorice is used singly or taken in a matched mode and is used for improving the skin allergy. The gamma-linolenic acid and anthocyanin enriched in the blackcurrant seeds and peels have the effects of promoting blood circulation, regulating the prostaglandin balance of a body and improving the immune system, and the external liniment is prepared by utilizing the residual seeds and fruit residues in the blackcurrant processing process, so that the treatment effect of improving the allergy symptoms is achieved.

The invention relates to the technical field of cosmetics, in particular to a blackhead-removing essence composition with efficient export and anti-inflammatory effects. The essence composition comprises the following components: water, glycolic acid, butanediol, a centella asiatica extract, a polygonum cuspidatum root extract, a scutellaria baicalensis root extract, a tea leaf extract, a glycyrrhiza glabra root extract, a chamomilla recutita flower extract, a rosemary leaf extract and triethanolamine. The glycolic acid in the raw materials is a cutin softener and has very small molecular weight, so that the glycolic acid can well permeate skin pores, and the cutin softening efficiency is higher; meanwhile, various plant essence components such as the scutellaria baicalensis root extract and the chamomile flower extract also have the capabilities of inhibiting dermatitis, enhancing skin resistance, neutralizing released histamine and preventing skin allergy, so that the blackhead-removing facial cleanser can play a role in efficiently removing blackheads under mild and non-irritating conditions, and also can enable the blackhead-removed skin to be white, tender and bright.

The present invention discloses an acne-relieving and allergy-soothing gel and a preparation method thereof. The acne-relieving and allergy-soothing gel is prepared from 1.9-6.74% of an acne-relievingand allergy-soothing composition, 10-20% of glycerin, 0.5-1% of carbomer, 0.5-1% of triethanolamine, 0.1-0.2% of methyl paraben and 71.06-87% of deionized water. The prepared acne-relieving and allergy-soothing gel is light yellow, crystal clear and transparent, suitable in viscosity, good in stability, and fresh and pleasant in smell. Experimental results show that the gel can inhibit propionibacterium acnes, remove acnes, remove scars and prevent allergy.

The pharmacological experiment shows that, the externally used preparation of Loratadine has very good allergy resisting and anti-inflammatory action to the rat passive cutaneous anaphylaxis (Rat PCA) model and dimethylbenzene caused mouse otitis model, in the experiment, it is found by chance that, the externally used preparation of Loratadine also has very fine inhibitory action to dinitrofluorobenzene caused mouse porphyria hypersensitivity (PTH), the novel pharmacological action mechanism of the Loratadine shows that the Loratadine external preparation has good therapeutic action to skin inflammations which mainly include porphyria hypersensitivity.

The invention discloses an adjustable nasal oxygen cannula and stomach tube fixing device capable of preventing pressure sores. The adjustable nasal oxygen cannula and stomach tube fixing device is characterized by comprising a stomach tube fixing belt, wherein the stomach tube fixing belt is of an arc shape; the stomach tube fixing belt is provided with a stomach tube clamping hole structure used for installing a nasogastric tube, and a fixing part used for fixing the stomach tube positioned on the face; and two ends of the stomach tube fixing belt are connected and fixed through connecting parts. The nasogastric tube fixing clamping hole structure can effectively fix a stomach tube and a nasal catheter, a thin rubber ring is arranged on the inner ring of the clamping hole, friction force between the stomach tube and the clamping hole is increased, and the stability of the stomach tube fixing structure is guaranteed. A medical foam dressing on the inner surface of the fixing belt has a high skin-friendly degree and good elasticity, is comfortable and non-sticky, and can quickly absorb parts of fluid, prevent the pressure sores and reduce facial skin allergy.

The invention relates to a skin allergen patch test diagnosis matrix composition and a preparation method thereof. The skin allergen patch test diagnosis matrix composition comprises the following components: a body temperature liquefaction composite matrix, a skin absorption promoter, a buffer solution, an electrolyte maintenance agent and the like. According to the skin allergen patch test diagnosis matrix composition provided by the invention, an allergen detection antigen is mixed with the composition and is coated on a patch test detection point, and the skin allergen patch test diagnosis matrix composition is coated on body surface skin to perform pathogenesis detection and diagnosis on contact allergy. Compared with the prior art, the skin allergen patch test diagnosis matrix composition provided by the invention has the advantages of changing the shortcomings that the traditional patch test adopts Vaseline as a single matrix; the allergen detection antigen is in a liquid state by adoption of the body temperature liquefaction composite matrix technology, therefore the allergen detection antigen is absorbed by the skin more easily; the skin barrier layer structure is changed in combination with the skin absorption promoter, so that the allergen antigen can better permeate; and meanwhile the buffer solution and the electrolyte maintenance agent protect the normal physiological functions of the detected skin tissue cells, and thus the detection result can be truly expressed. The components supplement each other and promote each other to greatly improve the allergen detection speed and detection sensitivity.

The invention provides a contact allergen agent combination and use thereof. Specifically, the invention relates to application of the contact allergen reagent combination to preparation of a kit fordiagnosing potential allergens of skin allergy of a subject, wherein the allergen reagent combination comprises at least five of the following groups of nickel sulfate, potassium dichromate, disperseblue 106, cobalt chloride, an aromatic mixture I, methylisothiazolinone, thiomersalate, sodium lauryl sulfate, a Carba mixture, formaldehyde, iodopropynal and p-phenylenediamine. The kit disclosed bythe invention can be used for rapidly and accurately identifying the skin allergens of Chinese people and is high in detection rate.

The invention discloses an application of fraxinellone in preparation of drugs for treating allergic skin diseases. The allergic skin diseases comprise urticaria, eczema, contact dermatitis, atopic dermatitis, anaphylactoid purpura and drug rash. According to the invention, fraxinellone is used for treating immune globulin E (IgE)-mediated skin diseases for the first time, and fraxinellone can promote Th1 type cells to generate IFN-gamma. 25 mg / kg of fraxinellone is given to mice with passive skin allergy, degranulation of skin tissue mast cells is inhibited, and the inhibition rate reaches 34.01%. 50 mg / kg of fraxinellone is given to mice with passive skin allergy, and the degranulation inhibition rate of skin mast cells reaches 54.34%. 100 mg / kg of fraxinellone is given to mice with passive skin allergy, and the degranulation inhibition rate of skin mast cells reaches 62.5%.

The invention provides a skin fitting device for peritoneal dialysis in the nephrology department. The skin fitting device comprises a bandage wound around the abdomen of a patient, a connector storage bag used for containing a connector is fixedly connected to the outer side of the bandage, the bandage is composed of a connecting part and a winding part, the winding part is integrally connected to the peripheral side of the connecting part, and a top plate is fixedly connected to the inner side of the connecting part. A first mounting hole is formed in the middle of the top plate, a dialysistube mounting base is fixedly connected to the outer side of the top plate, the dialysis tube mounting seat penetrates through the connecting part, a second mounting hole communicated with the first mounting hole is formed in the dialysis tube mounting base, a dialysis tube sequentially penetrates through the first mounting hole and the second mounting hole, and a rotating ring is rotatably connected to the inner side of the top plate; the rotating ring is provided with a plurality of air holes extending in the radial direction, the air holes penetrate through the side, away from the top plate, of the rotating ring, and the top plate is further connected with a driving unit for driving the rotating ring to rotate. The skin of the patient can be prevented from being in a damp-heat state fora long time, and skin allergy and bacterium breeding are effectively avoided.