Externally used loratadine formulation
A technology of loratadine and external preparations, which is applied in the field of pharmaceutical preparations and can solve problems such as not being ideal
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preparation example Construction
[0028] Preparation of antiserum Take 8 healthy rats weighing 90-100g and inject them intramuscularly with Na 2 SO 4 Ovalbumin (10mg / kg) recrystallized 3-5 times, and intraperitoneal injection of pertussis triple vaccine 2×10 10 / only. 10-14 days after the sensitization, the animals were sacrificed to collect blood, and the serum was separated by low-speed centrifugation, and stored in a -40°C refrigerator for later use.
[0029] Passive skin sensitization and antigen challenge Another 90 healthy rats with a body weight of 150-200g were randomly divided into normal control group, model group, high-dose liposome liniment group, low-dose liposome liniment group, Common liniment high-dose group, common liniment low-dose group, ointment high-dose group, ointment low-dose group and gavage control group. The hair on the back of the rat was cut off under anesthesia, and the diluted antiserum (1:6) was intradermally injected into the back of the rat for sensitization, and a total of...
Embodiment 1
[0089] Loratadine liposome liniment
[0090] Loratadine 10g
[0091] Lecithin 75g
[0092] Cholesterol 35g
[0093] Octadecylamine 2g
[0094] Vitamin E 5g
[0095] Tris buffer 1000ml
[0096] Preparation Process:
[0097] Dissolve the fat-soluble film material lecithin, cholesterol, octadecylamine, vitamin E and drug loratadine in the prescription in an appropriate amount of chloroform-ethanol mixed organic solvent (chloroform: ethanol volume ratio is 3: 1) , put on a rotary evaporator to evaporate the organic solvent, the lecithin cholesterol lipid forms a thin film on the wall of the round bottom flask, and the residual trace organic solvent is removed with nitrogen flow. The flask was connected to a vacuum pump and left overnight. Add 1000ml, hydrate the lipid film on a vortex shaker, sonicate for 10 minutes, place it at 45°C for 1 hour, and store it at a low temperature of 4°C.
Embodiment 2
[0099] Loratadine liposome liniment
[0100] Loratadine 4g
[0101] Lecithin 50g
[0102] Cholesterol 40g
[0103] Ceramide 20g
[0104] Vitamin E 15g
[0105] Tris buffer 1000ml
[0106] The preparation process is the same as in Example 1.
[0107] implementation benefit 3
[0108] Loratadine liposome liniment
[0109] Loratadine 12g
[0110] Lecithin 65g
[0111] Cholesterol 20g
[0112] Octadecylamine 5g
[0113] Vitamin E 10g
[0114] Menthol 3g
[0115] Tris buffer 1000ml
[0116] The preparation process is the same as in Example 1.
[0117] The liposome prepared by the above prescription and method has good stability, and the encapsulation efficiency measured by Sephadex (G-50) filtration method is all above 30%.
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