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Antiallergic drug gel and preparation method thereof

A gel, anti-allergic technology, used in drug delivery, drug combination, pharmaceutical formulations, etc., can solve problems such as poor permeability and poor water solubility, and achieve the effects of reducing adverse reactions, rapid onset of action, and convenient use.

Active Publication Date: 2014-10-22
HANGZHOU SHARPLY PHARM R&D INSTIT +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to solve the problem of poor water solubility of desloratadine in the background technology, which leads to poor skin permeability of its external preparations, and to provide a desloratadine with good skin absorption, fast onset, high bioavailability, and no side effects in vivo. small allergy medicine gel

Method used

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  • Antiallergic drug gel and preparation method thereof

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Effect test

Embodiment 1

[0019] Embodiment 1: prepare desloratadine gel, prescription is as follows:

[0020] Desloratadine Citrate 1g β-Cyclodextrin 2g

[0021] Azone 1g Carbomer 1g

[0022] Liquid paraffin 2g EDTA-Na 0.05g

[0023] Isopropanol 20g PEG-400 3g

[0024] Isopropyl myristate 6g Decyl oleate 6g

[0025] Purified water 61.95g

[0026] Preparation Process:

[0027] First, add β-cyclodextrin into water and stir to dissolve, then slowly add desloratadine citrate, and stir while adding until all dissolve to obtain desloratadine citrate-β-cyclodextrin solution; PEG-400, isopropyl myristate, decanyl oleate, azone, liquid paraffin, EDTA-Na, and isopropanol were heated in a water bath at 70°C and stirred to dissolve, then added desloratadine citrate-β- The cyclodextrin solution was stirred while adding to make it uniformly dispersed, and then added carbomer to make it swollen and dispersed uniformly to obtain desloratadine citrate gel.

Embodiment 2

[0028] Embodiment 2: prepare desloratadine gel, prescription is as follows:

[0029] Desloratadine tartrate 1.2g Beta-cyclodextrin 2.4g

[0030] N-methyl-pyrrolidone 1.2g Carbomer 1.5g

[0031] Liquid paraffin 1.8g EDTA-Na 0.1g

[0032] Isopropanol 18g PEG-400 3.5g

[0033] Isopropyl myristate 8g Decyl oleate 8g

[0034] Purified water 63.25g

[0035] Preparation Process:

[0036] First add β-cyclodextrin into water and stir to dissolve, then slowly add desloratadine tartrate, and stir while adding until completely dissolved to obtain desloratadine tartrate-β-cyclodextrin solution; mix PEG-400, Isopropyl myristate, decyl oleate, N-methyl-pyrrolidone, liquid paraffin, EDTA-Na, isopropanol are heated in a water bath at 70°C and stirred to dissolve, then add desloratadine tartrate-β-cyclopaste The fine solution was stirred while adding to make it evenly dispersed, and then added carbomer to make it swell and disperse evenly to obtain desloratadine tartrate gel.

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Abstract

The invention relates to an anti-allergy medicine gel and a preparation method thereof. The gel adopts Desloratadine acid salts as main ingredients and is used for treating skin allergic inflammations. The anti-allergy medicine gel disclosed herein adopts Desloratadine acid salts as main active ingredients and uses beta-cyclodextrin, thus the dissolvability of Desloratadine in water is greatly improved, the skin permeability is improved, the content of free drug of local tissues of the partial skin that having the allergic inflammation of the organism is improved through transdermal absorption, the sensitization of histamine can be effectively prevented, the local anti-allergy anti-inflammatory curative effects are achieved, and adverse reactions are reduced.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an antiallergic drug gel and a preparation method thereof. Background technique [0002] Desloratadine is a non-sedating long-acting tricyclic antihistamine, which is an active metabolite of loratadine, and can inhibit various allergic inflammatory processes by selectively blocking peripheral H1 receptors. Release of chemical mediators, such as: inhibit mast cells and basophils from releasing histamine, prostaglandins, leukocyte mediators, etc., relieve symptoms related to allergic rhinitis or chronic idiopathic urticaria. [0003] Currently, the dosage forms of desloratadine on the market are mainly oral dosage forms such as tablets, dispersible tablets, and syrups. These oral dosage forms experience first-pass drug effects in the gastrointestinal tract during oral administration, as well as metabolic effects of food and gastric emptying on the drug. And oral dosage ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/4545A61K47/48A61P37/08
Inventor 范敏华刘海姜双瑜刘华方利明
Owner HANGZHOU SHARPLY PHARM R&D INSTIT
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