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External-use formulation of fexofenadine

A technology of fexofenadine and external preparations, applied in the field of pharmaceutical preparations, can solve the problems of unfavorable treatment of allergic skin diseases, low concentration distribution and the like

Inactive Publication Date: 2006-08-09
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the concentration distribution of fexofenadine in the skin surface tissue with relatively less blood flow is relatively low, it is very unfavorable for the treatment of allergic skin diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0025] Preparation of antiserum Take 8 healthy rats with a body weight of 90-100g, and inject them intramuscularly on both sides of the rear thigh

[0026] Na 2 SO 4 Ovalbumin (10mg / kg) recrystallized 3-5 times, and intraperitoneal injection of pertussis triple vaccine 2×10 10 / only. 10-14 days after the sensitization, the animals were sacrificed to collect blood, and the serum was separated by low-speed centrifugation, and stored in a -40°C refrigerator for later use.

[0027]Passive skin sensitization and antigen challenge Another 90 healthy rats weighing 150-200g were randomly divided into normal control group, model group, high-dose liniment group, low-dose liniment group, high-dose ointment group, and ointment group according to body weight. Low-dose group and gavage control group. The hair on the back of the rat was cut off under anesthesia, and the diluted antiserum (1:6) was intradermally injected into the back of the rat for sensitization, and a total of four poin...

Embodiment 1

[0057] fexofenadine liniment

[0058] Fexofenadine 120g

[0059] Ethanol 35ml

[0060] Propylene glycol 180ml

[0061] Tween 80 2g

[0062] Phosphate buffered saline (PBS) to 1000ml

[0063] Preparation Process:

[0064] First dissolve fexofenadine in the prescribed amount of ethanol, propylene glycol and Tween 80, and then add the prescribed amount of phosphate buffer saline (PBS).

Embodiment 2

[0066] fexofenadine liniment

[0067] Fexofenadine 60g

[0068] Ethanol 200ml

[0069] Propylene glycol 500ml

[0070] Distilled water up to 1000ml

[0071] Preparation Process:

[0072] Dissolve fexofenadine in the prescribed amount of ethanol and propylene glycol, and then add distilled water to 1000ml.

[0073] The liniment prepared in embodiment 1 and embodiment 2 is packed in a specific container (sprayer or atomizer), and can be used as a spray.

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PUM

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Abstract

The present invention relates to a medicine fexofenadine preparation for external application. The pharmacological experiments show that said fexofenadine can obtain the obvious therapeutic effect for curing dermal allergic diseases.

Description

Technical field [0001] The invention belongs to the technology of pharmaceutical preparations. Background technique [0002] In recent years, due to climate and environmental changes, various harmful gases, dust and other pollution sources have emerged in large numbers, making them allergens that cause people to have various allergic reactions. Seasonal changes, field work, pollen allergies, inhalation of harmful gases and dust particles, etc., have caused more and more people to suffer from various types of allergic diseases, such as allergic rhinitis, urticaria, skin redness, itching, rashes, etc. Red spots and asthma caused by allergens are very common. Therefore, it is very important to pay attention to environmental changes, strengthen self-care, and develop drugs for the treatment of allergies. [0003] Fexofenadine was developed by (Germany) Hoechst Marion Roussel, first listed in the United States in 1996, and listed in the UK in March 1997. It is an orally effecti...

Claims

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Application Information

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IPC IPC(8): A61K31/445A61K9/06A61K9/12A61P37/08
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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