External-use formulation of fexofenadine
A technology of fexofenadine and external preparations, applied in the field of pharmaceutical preparations, can solve the problems of unfavorable treatment of allergic skin diseases, low concentration distribution and the like
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[0025] Preparation of antiserum Take 8 healthy rats with a body weight of 90-100g, and inject them intramuscularly on both sides of the rear thigh
[0026] Na 2 SO 4 Ovalbumin (10mg / kg) recrystallized 3-5 times, and intraperitoneal injection of pertussis triple vaccine 2×10 10 / only. 10-14 days after the sensitization, the animals were sacrificed to collect blood, and the serum was separated by low-speed centrifugation, and stored in a -40°C refrigerator for later use.
[0027]Passive skin sensitization and antigen challenge Another 90 healthy rats weighing 150-200g were randomly divided into normal control group, model group, high-dose liniment group, low-dose liniment group, high-dose ointment group, and ointment group according to body weight. Low-dose group and gavage control group. The hair on the back of the rat was cut off under anesthesia, and the diluted antiserum (1:6) was intradermally injected into the back of the rat for sensitization, and a total of four poin...
Embodiment 1
[0057] fexofenadine liniment
[0058] Fexofenadine 120g
[0059] Ethanol 35ml
[0060] Propylene glycol 180ml
[0061] Tween 80 2g
[0062] Phosphate buffered saline (PBS) to 1000ml
[0063] Preparation Process:
[0064] First dissolve fexofenadine in the prescribed amount of ethanol, propylene glycol and Tween 80, and then add the prescribed amount of phosphate buffer saline (PBS).
Embodiment 2
[0066] fexofenadine liniment
[0067] Fexofenadine 60g
[0068] Ethanol 200ml
[0069] Propylene glycol 500ml
[0070] Distilled water up to 1000ml
[0071] Preparation Process:
[0072] Dissolve fexofenadine in the prescribed amount of ethanol and propylene glycol, and then add distilled water to 1000ml.
[0073] The liniment prepared in embodiment 1 and embodiment 2 is packed in a specific container (sprayer or atomizer), and can be used as a spray.
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