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External-use formulation of levocetirizine hydrochloride

A technology of levocetirizine and external preparations, applied in the field of pharmaceutical preparations, can solve problems such as toxic reactions, arrhythmia and the like

Inactive Publication Date: 2006-08-09
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have also shown that the dose of terfenadine that can significantly improve asthma symptoms has the risk of causing arrhythmia, so some people think that it is not suitable to use terfenadine to prevent and treat allergic asthma, and it is easy to interact with multiple drugs to produce toxic reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0040] Preparation of antiserum Take 8 healthy rats with a body weight of 90-100g, and inject them intramuscularly on both sides of the rear thigh

[0041] Na 2 SO 4 Ovalbumin (10mg / kg) recrystallized 3-5 times, and intraperitoneal injection of pertussis triple vaccine 2×10 10 / only. 10-14 days after the sensitization, the animals were sacrificed to collect blood, and the serum was separated by low-speed centrifugation, and stored in a -40°C refrigerator for later use.

[0042] Passive skin sensitization and antigen challenge Another 90 healthy rats weighing 150-200g were randomly divided into normal control group, model group, high-dose liniment group, low-dose liniment group, high-dose ointment group, and ointment group according to body weight. Low-dose group and gavage control group. The hair on the back of the rat was cut off under anesthesia, and the diluted antiserum (1:6) was intradermally injected into the back of the rat for sensitization, and a total of four poi...

Embodiment 1

[0072] Levocetirizine Liniment

[0073] Levocetirizine 20g

[0074] Ethanol 35ml

[0075] Propylene glycol 100ml

[0076] Phosphate buffered saline (PBS) to 1000ml

[0077] Preparation Process:

[0078]First dissolve levocetirizine in an appropriate amount of phosphate buffered saline (PBS), add the prescribed amount of ethanol and propylene glycol, and then add phosphate buffered saline (PBS) to 1000ml.

Embodiment 2

[0080] Levocetirizine Liniment

[0081] Levocetirizine 10g

[0082] Ethanol 200ml

[0083] Propylene glycol 300ml

[0084] Distilled water up to 1000ml

[0085] Preparation Process:

[0086] Dissolve levocetirizine in an appropriate amount of distilled water first, add the prescribed amount of ethanol and propylene glycol, and then add distilled water to 1000ml.

[0087] The liniment prepared in embodiment 1 and embodiment 2 is packed in a specific container (sprayer or atomizer), and can be used as a spray.

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PUM

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Abstract

The present invention relates to a medicine levocetirizine hydrochloride preparation for external application. Said preparation is made up by using levocetirizine hydrochloride as active effective component and medicinal auxiliary material, and can be used for effectively curing various dermal allergic diseases.

Description

Technical field [0001] The invention belongs to the technology of pharmaceutical preparations. Background technique [0002] In recent years, due to climate and environmental changes, various harmful gases, dust and other pollution sources have emerged in large numbers, making them allergens that cause people to have various allergic reactions. Seasonal changes, field work, pollen allergies, inhalation of harmful gases and dust particles, etc., have caused more and more people to suffer from various types of allergic diseases, such as allergic rhinitis, urticaria, skin redness, itching, rashes, etc. Red spots and asthma caused by allergens are very common. Therefore, it is very important to pay attention to environmental changes, strengthen self-care, and develop drugs for the treatment of allergies. [0003] Although the CNS, oral mucosa dryness, cardiovascular and gastrointestinal adverse reactions of cetirizine are very small, the latest research has found that the anti...

Claims

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Application Information

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IPC IPC(8): A61K31/495A61K9/06A61P37/08A61P17/00
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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