External-use formulation of levocetirizine hydrochloride
A technology of levocetirizine and external preparations, applied in the field of pharmaceutical preparations, can solve problems such as toxic reactions, arrhythmia and the like
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[0040] Preparation of antiserum Take 8 healthy rats with a body weight of 90-100g, and inject them intramuscularly on both sides of the rear thigh
[0041] Na 2 SO 4 Ovalbumin (10mg / kg) recrystallized 3-5 times, and intraperitoneal injection of pertussis triple vaccine 2×10 10 / only. 10-14 days after the sensitization, the animals were sacrificed to collect blood, and the serum was separated by low-speed centrifugation, and stored in a -40°C refrigerator for later use.
[0042] Passive skin sensitization and antigen challenge Another 90 healthy rats weighing 150-200g were randomly divided into normal control group, model group, high-dose liniment group, low-dose liniment group, high-dose ointment group, and ointment group according to body weight. Low-dose group and gavage control group. The hair on the back of the rat was cut off under anesthesia, and the diluted antiserum (1:6) was intradermally injected into the back of the rat for sensitization, and a total of four poi...
Embodiment 1
[0072] Levocetirizine Liniment
[0073] Levocetirizine 20g
[0074] Ethanol 35ml
[0075] Propylene glycol 100ml
[0076] Phosphate buffered saline (PBS) to 1000ml
[0077] Preparation Process:
[0078]First dissolve levocetirizine in an appropriate amount of phosphate buffered saline (PBS), add the prescribed amount of ethanol and propylene glycol, and then add phosphate buffered saline (PBS) to 1000ml.
Embodiment 2
[0080] Levocetirizine Liniment
[0081] Levocetirizine 10g
[0082] Ethanol 200ml
[0083] Propylene glycol 300ml
[0084] Distilled water up to 1000ml
[0085] Preparation Process:
[0086] Dissolve levocetirizine in an appropriate amount of distilled water first, add the prescribed amount of ethanol and propylene glycol, and then add distilled water to 1000ml.
[0087] The liniment prepared in embodiment 1 and embodiment 2 is packed in a specific container (sprayer or atomizer), and can be used as a spray.
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