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Composition for alleviating skin allergy and redness and application thereof in infant body lotions

A skin allergy and composition technology, applied in the field of infant skin care products, can solve the problems of insignificant efficacy, inability to significantly improve skin problems, increase product side effects, etc., and achieve enhanced plasminogen activity and bad smell. The effect of prolonging time and improving stability

Inactive Publication Date: 2017-04-26
SHANGHAI CHILDRENS NUTRITION CENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Most of the ordinary moisturizers on the market now use mineral oil as the base oil. If used for a long time, the oil will accumulate, hinder the cell metabolism, and accelerate the aging of the cells
At the same time, the efficacy of infant skin care products on the market is not significant, and cannot significantly improve skin problems, such as allergies, redness, swelling, etc.
The main reason for this problem is that the active substance is absorbed in a small amount and cannot play a therapeutic role
If the content of active ingredients is increased, the side effects of the product will be increased, leading to the occurrence of other adverse reactions

Method used

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  • Composition for alleviating skin allergy and redness and application thereof in infant body lotions
  • Composition for alleviating skin allergy and redness and application thereof in infant body lotions
  • Composition for alleviating skin allergy and redness and application thereof in infant body lotions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0038] The specific examples of the formulation of the composition provided by the present invention are as follows. The examples given are not meant to limit the present invention. Unless otherwise specified, the amount of active ingredients is in parts by weight.

[0039] Example 1 Example 2 Example 3 Allantoin506070 Grapefruit seed extract152010 Garlic extract352020

[0040] The liposome encapsulating the composition is obtained by the following steps:

[0041] (1) Dissolve the composition in 0.05 mol / L phosphate buffer salt with a pH of 7 to prepare a 20 mg / ml composition solution; heat to 50°C and maintain a constant temperature;

[0042] (2) Dissolve lecithin and cholesterol in absolute ethanol at a mass ratio of 1:1 to obtain a mixed solution;

[0043] (3) Under the condition of stirring, add the mixed solution to the solution kept at a constant temperature in step (1), stir for 30 minutes, and rotate to evaporate to remove residual ethanol; ultrasonic treatment for 10 m...

Embodiment 4-8

[0045] An example of the application of the liposomes involved in the present invention in moisturizers is as follows, the total amount of phase A, phase B and phase C components is 100 parts:

[0046]

[0047] The preparation method of the above body lotion is as follows: add the ingredients of phase A to water in sequence, stir at room temperature for 40min; heat phase B to 85℃, stir to dissolve; add phase B to phase A at a speed of 600rpm Homogenize and emulsify for 30 minutes. Add phase C to phase A and stir at 50°C for 30 minutes.

[0048] The products prepared in the above-mentioned Example 4 and Example 5 were placed at room temperature and 45 degrees, respectively, to investigate the stability of the product and the change in active content. The results are shown in the table below.

[0049]

[0050]

[0051]

[0052] It can be seen from the above test results that the composition encapsulated by liposome technology can improve the stability of the grapefruit seed extract a...

Embodiment 9

[0060] Verify the effect of ultrasonic treatment

[0061] The liposomes of the composition of Example 3 were obtained according to the following steps:

[0062] (1) Dissolve the composition in 0.05mol / L phosphate buffer salt with a pH of 7 to prepare a 20mg / ml composition solution; heat to 50°C and maintain a constant temperature;

[0063] (2) Dissolve lecithin and cholesterol in absolute ethanol at a mass ratio of 1:1 to obtain a mixed solution;

[0064] (3) Under the condition of stirring, add the mixed solution to the solution kept at a constant temperature in step (1), stir for 30 minutes, and rotate to evaporate to remove residual ethanol; ultrasonic treatment for 10 minutes, the liposomes encapsulating the composition are obtained. The power of the ultrasonic treatment is 200W.

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Abstract

The invention discloses a composition for alleviating skin allergy and redness and application thereof in infant body lotions. The composition for alleviating skin allergy and redness is composed of allantoin, a grapefruit seed extract and a garlic extract. The composition provided by the invention can effectively moisturize the skin and alleviate skin allergy and redness, and by means of a unique liposome encapsulation technology, the composition can be prepared into liposome to increase active matter absorption, thereby decreasing the adding amount of active matters, and reducing the side effects of products.

Description

Technical field [0001] The present invention relates to the field of infant skin care products, in particular to a composition for reducing skin allergic redness and its application in an infant moisturizer. Background technique [0002] The stratum corneum of the baby's skin is very thin, the skin is delicate, and the baby's sweat glands secrete vigorously, the skin is not fully developed, and the ability to control acid-base is poor. It can only rely on an acidic protective film on the skin to protect the skin and prevent bacterial infections. If it is stimulated by the outside, it may cause allergies, redness and swelling. [0003] Babies’ skin is very tender and sensitive, and has poor resistance to the environment. Therefore, moisturizers containing natural moisturizing ingredients are needed. There are many types of baby moisturizers on the market, which generally contain moisturizing factors and natural mineral oil. Effectively moisturize the baby's skin, prevent chapped sk...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/9789A61K8/49A61K8/14A61Q19/00
CPCA61K8/14A61K8/4946A61K8/97A61Q19/005A61K2800/82A61K2800/52A61K8/9789A61K8/9794A61K8/8152A61K8/60A61K8/44A61K8/37A61K8/31A61K8/604A61K8/342A61Q19/00
Inventor 邓文峰
Owner SHANGHAI CHILDRENS NUTRITION CENT CO LTD
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