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Contact allergen reagent combination and use thereof

An allergen and contact technology, applied in the medical field, can solve problems such as no allergen series

Pending Publication Date: 2021-02-02
SHANGHAI DERMATOLOGY HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, to date, there is no national standard method or allergen series for patch testing based on evidence-based medicine in China

Method used

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  • Contact allergen reagent combination and use thereof
  • Contact allergen reagent combination and use thereof
  • Contact allergen reagent combination and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120] Determination of allergens

[0121] New chemical products have exploded in the past few decades, and the types and quantities of skin allergens that Chinese people may be exposed to have also changed dramatically. Skin allergies have become very common, and some allergens manifest in different regions and time spans. obvious changes.

[0122] Based on the inventor's analysis and research, combined with a large number of clinical practices, the skin allergens suitable for China's national conditions have been determined, as shown in Table 1.

[0123] Table 1 List of allergens

[0124]

[0125]

[0126] When the excipient is vaseline, it is solid (or quasi-solid), and the concentration represents the percentage (%) based on the total weight; when the excipient is water, it is liquid, and the concentration represents the volume percentage based on the total volume.

Embodiment 2

[0128] Epidemiological validation based on literature data

[0129] In order to verify whether the allergens screened by the present invention (60 kinds of allergens in Table 1) are common contact allergens in China, epidemiological verification is carried out based on literature data, and the patch test research covering all domestic reports is summarized, with Verify and analyze the proportion of positive reactions of allergens detected in China, so as to determine or verify the allergens with high positive reactions included in the spot test device of the present invention.

[0130] Three Chinese databases were searched: Chinese National Knowledge Infrastructure (CNKI), Chinese Technical Journal VIP Database and Wanfang Data, as well as Chinese and English literature published in PubMed. The content includes the results of patch tests in China from 1987 to June 2018. Search terms included: patch test, and allergic contact dermatitis, facial dermatitis, eczema, atopic derma...

Embodiment 3

[0184] Kits for the identification of potential allergens

[0185] The kit of the present embodiment includes 60 kinds of allergen reagents as described in Table 1 (i.e. G1-G60 in Table 2), excipients (comprising glycerol and water), and a spot tester, which includes : substrate, the substrate is a polyurethane film with hyposensitive adhesive; The patch chamber is lined with filter paper and can be used to load allergen reagents; each substrate has four columns of 5 patch chambers spaced apart from each other. The patch chambers are numbered respectively on the back of the substrate.

[0186] When in use, the allergen reagents were mixed with corresponding excipients at corresponding concentrations as shown in Table 1, loaded on the filter paper lining of the patch chamber, and then pasted on the skin of the test subject.

[0187] 60 allergens can be loaded sequentially according to A1-A5, a set is divided into 3 spot testers, the first spot tester loads the basic antigen s...

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Abstract

The invention provides a contact allergen agent combination and use thereof. Specifically, the invention relates to application of the contact allergen reagent combination to preparation of a kit fordiagnosing potential allergens of skin allergy of a subject, wherein the allergen reagent combination comprises at least five of the following groups of nickel sulfate, potassium dichromate, disperseblue 106, cobalt chloride, an aromatic mixture I, methylisothiazolinone, thiomersalate, sodium lauryl sulfate, a Carba mixture, formaldehyde, iodopropynal and p-phenylenediamine. The kit disclosed bythe invention can be used for rapidly and accurately identifying the skin allergens of Chinese people and is high in detection rate.

Description

technical field [0001] The invention relates to the medical field, in particular to a combination of contact allergen reagents and uses thereof. Background technique [0002] The patch test (Patch Test) is a simple and reliable method to identify allergens in patients with dermatitis eczema. When a patient is allergic to an allergen due to skin or mucous membrane contact, any part of the body surface in contact with the same allergen or a substance with a similar chemical structure and the same antigenicity will soon appear skin inflammatory changes at the contact site. This is allergic contact dermatitis. Patch test is to use this principle to artificially configure suspicious allergens to a certain concentration, place them in a special small room and apply them on the covered parts of the human body (usually on the back and upper arm extension side). After a certain period of time, Determine whether the test substance is an allergen (ie, a sensitizer) according to wheth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
CPCA61K49/0006
Inventor 邹颖李邻峰肖翔高延瑞张洢祎
Owner SHANGHAI DERMATOLOGY HOSPITAL
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