Osthole-mixing ointment, preparation method and applications

A technology of osthole and ointment, applied in the directions of ointment delivery, drug combination, pharmaceutical formulation, etc., can solve problems such as allergic reactions of patients, and achieve the effects of overcoming skin allergies, accelerating blood microcirculation, and increasing absorption

Inactive Publication Date: 2013-10-09
CHONGQING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the ointment needs to be applied on the patient's body surface, it may cause allergic reactions in some patients

Method used

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  • Osthole-mixing ointment, preparation method and applications
  • Osthole-mixing ointment, preparation method and applications
  • Osthole-mixing ointment, preparation method and applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of embodiment 1 osthole mixed ointment

[0015] Weigh 5 g of osthole, 2 g of ligustrazine, 1 g of Vit C, 1 g of Vit E, 5 g of glycerin, 1 g of sodium lauryl sulfate, 8 g of white petrolatum, 8 g of stearyl alcohol, 6 g of monoglyceride, 6 g of liquid paraffin, and paraben Ethyl ester 0.05g, add water to make up to 100g. Slowly heat Vit E, liquid paraffin, monoglyceride, stearyl alcohol, and white petrolatum in a water bath to melt, and keep warm at 75°C as the oil phase. Separately take Vit C, glycerin, ethylparaben, sodium lauryl sulfate and appropriate amount of water and slowly heat and dissolve as the water phase. When the temperature rises to the same level as the oil phase, slowly add the oil phase to the water phase. Stir continuously, and when the temperature drops to about 60°C, add osthole and ligustrazine powder, stir well and cool to obtain osthole mixed ointment as experimental group I.

[0016] According to the above method, 4 g of osthol...

Embodiment 2

[0017] The physical and chemical property investigation of embodiment 2 osthole mixed ointment

[0018] According to the formula and preparation method of "Osthole Ointment" prepared by a certain hospital in Chongqing, osthole was ground into fine powder, added Vaseline, and ground to make a 10% osthole ointment, which was used as the osthole ointment group.

[0019] Centrifugal test: take an appropriate amount of ointment in a centrifuge tube, at 3000r min -1 Centrifuge for 30min. After many tests. The ointment that each experimental group that embodiment 1 obtains and control group makes has no delamination. Heat resistance test: place in a constant temperature incubator at 40°C for 20 days, and observe the results (see Table 1). Cold resistance test: place in a -18°C refrigerator for 20 days, and observe the results (see Table 2).

[0020] Table 1 Comparison of the shapes of the experimental group and the control group placed in a 40°C constant temperature incubator for...

Embodiment 3

[0024] Example 3 Investigation of the anti-inflammatory and analgesic activity of osthole mixed ointment

[0025] For the study of the effect on ear swelling in mice, 60 mice were taken, weighing 18-22g, half male and half male. They were randomly divided into control group, aspirin group, osthole ointment group, experimental group Ⅰ, Ⅱ, Ⅲ63 experimental groups, 10 rats in each group. Described administration group smears the medicine group medicine that embodiment 1 obtains evenly on both sides of left auricle of mice, dosage is as shown in table 3, every day 2 times, continuous 5d, after the last application of medicine 30min, wash ointment, Apply xylene at the same place on both sides of the right ear with 0.1 mL / cause, and use the left ear as a control, and kill them after 30 minutes. Ear slices from the same parts of the left and right ears were taken with a 6mm punch, weighed, and the degree of swelling (mass of the left ear - mass of the right ear) was calculated. for...

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Abstract

The invention provides an osthole-mixing ointment, and the active components in the formula comprise osthole and ligustrazine. The ointment has a stronger inhibition effect on skin allergy, overcomes the problem of patient skin allergy directly existed in some other antiphlogistic analgesic medicines, and has a good application prospect in anti-inflammation, analgesia and eczema treatment.

Description

technical field [0001] The invention relates to an external preparation, in particular to an osthole mixed ointment with antibacterial, anti-inflammatory and analgesic effects, a preparation method and application. technical background [0002] In the external treatment of traditional Chinese medicine, plaster plays an important role in treating diseases. In order for traditional medicine to go abroad, it not only requires major reforms in dosage forms and production processes, but also requires faster curative effects, cleaner and more convenient to have strong vitality. According to the clinical survey of patients with various diseases, more than 90% of them are willing to accept external treatment to treat diseases if they have the same curative effect. Because its route of administration is directly from the skin to the lesion and participates in blood circulation, it is often faster and more direct than oral administration. What's more worth mentioning is that for dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4965A61K9/06A61P29/00A61P17/00A61P37/06A61P37/08A61P31/00A61P17/04A61K31/37
Inventor 杨宪杨水平张雪唐倩余晓东和七一况刚何兴国
Owner CHONGQING NORMAL UNIVERSITY
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