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Application of CCR4 receptor antagonist in preparation of medicine for treating drug rash

A receptor antagonist and drug eruption technology, which is applied in the application field of CCR4 receptor antagonists in the preparation of drug eruption drugs, can solve the problems of poor curative effect and easy occurrence of infection in severe drug eruptions, and achieves fast onset time and pain relief. Effect

Active Publication Date: 2020-03-31
FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the methods for clinical treatment of drug eruption include: 1. antihistamine drug treatment; 2. glucocorticoid anti-inflammatory and anti-allergic treatment; 3. gamma globulin treatment; 4. TNF-α antagonist treatment; However, antihistamines are not effective in controlling severe drug eruptions, and drugs such as glucocorticoids and TNF-α antagonists are prone to adverse reactions such as infection

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  • Application of CCR4 receptor antagonist in preparation of medicine for treating drug rash
  • Application of CCR4 receptor antagonist in preparation of medicine for treating drug rash
  • Application of CCR4 receptor antagonist in preparation of medicine for treating drug rash

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Embodiment Construction

[0011] The present invention will be described in further detail below in conjunction with accompanying drawing, but said content should not be regarded as the restriction of the present invention, method in the present embodiment is all operated by routine method if there is no special instruction, and reagent used adopts conventional reagent if there is no special instruction Or reagents configured by conventional methods.

[0012] The use of the CCR4 receptor antagonist of the present invention is the application of the CCR4 receptor antagonist in the preparation of medicaments for treating drug eruption.

[0013] The drug eruption is exanthematous drug eruption or urticaria type drug eruption.

[0014] The CCR4 receptor antagonist is AZD2098, and the drug eruption is exanthematous drug eruption.

[0015] The CCR4 receptor antagonist is Compound22, and the drug eruption is urticarial type drug eruption.

[0016] The medicine can be made into tablets, injections or externa...

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Abstract

The invention discloses application of a CCR4 receptor antagonist, particularly to application of a CCR4 receptor antagonist in preparation of medicine for treating drug rash. The CCR4 receptor antagonist has the better effect than prednisone acetate and has the quick effect, so that the pain of a patient is relieved more quickly. The CCR4 receptor antagonist has a quick effect especially on the eruption rash or urticaria type rash to alleviate the pain of the patient quickly. When the CCR4 receptor antagonist is AZD2098, the CCR4 receptor antagonist has a good curative effect on the drug rash, especially on the eruption rash; and when the CCR4 receptor antagonist is Compond22, the CCR4 receptor antagonist has a good curative effect on the drug rash, especially the urticaria type drug rash.

Description

technical field [0001] The invention relates to the application of a CCR4 receptor antagonist in the preparation of drug eruption medicine, especially the application of AZD2098 and Compound22 in the treatment of drug eruption. Background technique [0002] Dermatitis refers to a general term for skin inflammatory diseases caused by various internal and external infections or non-infectious factors. It is not an independent disease. Its etiology and clinical manifestations are complex and diverse, and it recurs repeatedly, making clinical treatment difficult. Drug eruption, also known as dermatitis medicamentosa, is an inflammatory reaction of the skin and mucous membranes caused by drugs entering the human body through oral administration, injection, inhalation, suppositories, and external drug absorption. Drug eruptions can be divided into mild and severe. Mild drug eruptions include: maculopapular exanthema (MPE), erythema multiforme (EM), fixed drug eruption (FDE), and u...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61K31/4965A61P17/00A61P17/04
CPCA61K31/519A61K31/4965A61P17/00A61P17/04Y02A50/30
Inventor 李玉叶况轶群唐俊婷
Owner FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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