Application of astaxanthin in the preparation of products for the prevention or treatment of preeclampsia

A technology of preeclampsia and astaxanthin, which is applied in the field of application of astaxanthin in the preparation of products for the prevention or treatment of preeclampsia, can solve problems to be studied, and achieve high safety, lower blood pressure, and reduced fibrin deposition Effect

Active Publication Date: 2017-11-24
NINGBO UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Based on the above characteristics of astaxanthin, the application of astaxanthin in the treatment or prevention of diseases has been studied in many aspects, such as the Chinese invention patent "Astaxanthin in the preparation of prevention and treatment of brain disease" with application number 200810195924.6 (publication number CN101361726A). Application of stroke medicine", application number 201210418725.3 (application publication number is CN102895219A) Chinese invention patent "Application of astaxanthin in fetal alcohol-related diseases", application number is 201110390169.9 (application publication number is CN102389407A) China Invention patent "Application of astaxanthin in the preparation of medicines for treating and preventing pulmonary fibrosis", application number 201310018433.5 (application publication number is CN103040797A) Chinese invention patent "Astaxanthin in the preparation and prevention of embryotoxicity caused by organophosphorus pesticides "Application in Drugs", Application No. 201310315191.6 (Application Publication No. CN103462945A) Chinese Invention Patent "A Application of Haematococcus Astaxanthin in the Preparation of Drugs for Protecting or Restoring Kidney Function", etc. The application in the treatment or prevention of preeclampsia has not been reported at present, and the characteristics of astaxanthin's antioxidant, blood pressure lowering and anti-inflammation can just target the pathological mechanism of preeclampsia. The application of

Method used

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  • Application of astaxanthin in the preparation of products for the prevention or treatment of preeclampsia
  • Application of astaxanthin in the preparation of products for the prevention or treatment of preeclampsia
  • Application of astaxanthin in the preparation of products for the prevention or treatment of preeclampsia

Examples

Experimental program
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Effect test

Embodiment 1

[0014] Example 1: Establishment of a rat model of preeclampsia

[0015] Normal adult SD rats, 250-260g for females and 280-300g for males, provided by Zhejiang Academy of Medical Sciences (Hangzhou City, Zhejiang Province), 1:3 cages, after confirming pregnancy, the pregnant SD rats were randomly divided into three groups : Normal modeling group, blank group and astaxanthin group (20 in each group). On the sixth day after co-cage (the fifth day of pregnancy), animals in the astaxanthin group were given 15mg / d.kg.bw, 25mg / d.kg.bw, 35mg / d.kg.bw astaxanthin (Ningbo Honglong). Biotechnology Co., Ltd.), the normal modeling group and the blank group were given the same amount of normal saline every day until the end (21st day after cage closure). From the 10th day to the end of the cage (the 21st day after the cage), the blank group and the astaxanthin group were injected with L-L-arginine nitrite (L-NAME) 125mg / d·kg·bw daily , The normal modeling group was injected with the same amo...

Embodiment 2

[0016] Example 2: Histopathological examination

[0017] On the 21st day after co-cage, the blood pressure and urine protein of each group of animals were measured, and then the femoral arteries of each group of animals were bled and sacrificed. The blood of the abdominal aorta of each group was collected, the serum was separated, and the peroxide (MDA) in the serum was detected. , Nitric oxide (NO) content, superoxide dismutase (SOD), nitric oxide synthase (NOS) enzyme activity. At the same time, placental tissue was taken for histopathological examination to analyze the deposition area of ​​fibrin, and immunohistochemical detection of NF-κB, HO-1 and Rock II protein expression in placental tissue.

[0018] As shown in Table 1, in the blank group, after the pregnant rats were treated with L-NAME (125mg / d·kg·bw), their systolic blood pressure and diastolic blood pressure increased, and the systolic blood pressure increased by 25.75% (P <0.05), the diastolic blood pressure increased...

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Abstract

The invention relates to the application of astaxanthin in the preparation of products for the treatment or prevention of preeclampsia, which is mainly used to reduce the blood pressure of individuals with preeclampsia and regulate the internal oxidative stress indicators of individuals with preeclampsia. After using astaxanthin, the blood pressure of the pregnant mice in the preeclampsia model of the present invention decreased significantly, the urine protein decreased, the MDA in the blood decreased, and the NO and SOD increased, and at the same time, the Rock II in the placental tissue was significantly down-regulated. , NF‑κB, the number of trophoblasts in placental tissue increases, fibrin deposition decreases, basement membrane thickening improves, and it has a good therapeutic effect on the symptoms of preeclampsia. Compared with the prior art, astaxanthin is non-toxic, has low side effects, and has high safety. The present invention provides the application of astaxanthin in the preparation of products for the prevention or treatment of preeclampsia, broadens the application range of astaxanthin, and also It provides a new way for the prevention and treatment of preeclampsia.

Description

Technical field [0001] The invention relates to a new application of astaxanthin in the field of disease treatment, in particular to the application of astaxanthin in the preparation of products for the prevention or treatment of preeclampsia. Background technique [0002] Preeclampsia is a serious obstetric disease unique to pregnancy. It mainly manifests as hypertension and proteinuria. It is one of the main reasons for the increase in maternal and perinatal mortality. In recent years, studies have shown that abnormal oxidative stress in pregnant women during pregnancy is a risk factor for preeclampsia. The toxic effects of oxidative stress cause severe damage to pregnant women's vascular endothelial cells, cell membranes, and blood vessel inner walls, causing abnormally high blood pressure. In addition, excessive intravascular inflammation in preeclampsia also causes endothelial cell damage. At present, the clinical treatment of preeclampsia is based on magnesium sulfate anti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61P15/00A61P9/12
Inventor 高鑫陈海敏宣荣荣严小军
Owner NINGBO UNIV
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