Application and kit of combined amine metabolic markers

A metabolic marker and combined technology, applied in biological testing, material inspection products, etc., can solve problems such as difficult diagnosis and strong concealment of hepatic encephalopathy

Active Publication Date: 2016-09-07
HANGZHOU HEALTH BANK MEDICAL LAB CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of strong concealment and difficult diagnosis of early hepatic encephalopathy, and finds a new combination that can be applied to the diagnosis of early hepatic encephalopathy. The characteristics and detection methods of the above-mentioned combined amine markers are as follows:

Method used

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  • Application and kit of combined amine metabolic markers
  • Application and kit of combined amine metabolic markers
  • Application and kit of combined amine metabolic markers

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Experimental program
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Effect test

Embodiment 1

[0021] 1. Serum sample collection Before the collection, the included volunteers signed the informed consent.

[0022] Inclusion criteria for the liver cirrhosis group: refer to the 2010 revised guidelines for the prevention and treatment of chronic hepatitis B [11].

[0023] Inclusion criteria for early hepatic encephalopathy: Patients with cirrhosis who had received at least 5 years of education were selected as research subjects, in which the number connection test-A, number-symbol test or EEG Figure three If there is at least one abnormality in the diagnosis of patients, the diagnosis is early hepatic encephalopathy.

[0024] Inclusion criteria for the healthy control group: people with normal physical examination (between 40 and 70 years old), and those who are healthy in physical examination.

[0025] Serum samples were used under the same conditions: serum samples from 33 normal persons, 15 cases of liver cirrhosis, and 23 patients with early hepatic encephalopathy (1...

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Abstract

The present invention relates to an application of amine metabolites in serum: aspartic acid, ornithine, hypoxanthine, phenylalanyl phenylalanine and glutamine phenylalanine as combination markers in preparation of a kit for early hepatic encephalopathy paints for diagnosis subjects, The invention also relates to the kit for detecting early hepatic encephalopathy paints for diagnosis subjects, by detecting relative concentration of the amine metabolism marker in serum of the diagnosis subjects, based on a binary logistic regression equation to calculate combination marker variate Prob and estimate intercept point value, so that whether the diagnosis subject is early hepatic encephalopathy paint or not can be determined. The kit has the characteristics of low detection cost and good stability. The kit can be used for clinical diagnosis for early hepatic encephalopathy, and has characteristics of high diagnostic specificity and high sensitivity, has characteristics of complementation with traditional clinical diagnostic marker blood ammonia, and has high development and application values.

Description

technical field [0001] The invention relates to the application of a new amine combination marker in the diagnosis of early hepatic encephalopathy. It belongs to the fields of analytical chemistry, clinical medicine and medicine. Background technique [0002] Hepatic encephalopathy (Hepatic encephalopathy, HE) is a syndrome of central nervous system dysfunction based on metabolic disorders caused by acute and chronic liver failure or various portosystemic shunts. This syndrome is common in end-stage liver cirrhosis. According to the degree of disturbance of consciousness, neurological manifestations and EEG changes, HE can be divided into stages 0-4 (west Haven stage) from mild mental changes to deep coma. Early hepatic encephalopathy (such as stage 0, that is, mild hepatic encephalopathy MHE) is a special stage in the development of hepatic encephalopathy, with the characteristics of high incidence and strong concealment. The incidence rate in my country is 24.7%-85%. The ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
Inventor 许国旺罗萍尹沛源黄强
Owner HANGZHOU HEALTH BANK MEDICAL LAB CO LTD
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