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Application of long non-coding RNA uc.48+ small interfering RNA in the preparation of drugs for diabetic neuropathic pain

A technology of neuropathic pain and ribonucleic acid, which is applied in the direction of nervous system diseases, drug combinations, non-central analgesics, etc., and can solve the problems of limited research on long non-coding RNA

Active Publication Date: 2018-10-23
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, breakthroughs have been made in the research of non-coding RNAs (such as microRNA, siRNA and piRNA) with a length of less than 50 nucleotides, but there are not many studies on functional long non-coding RNAs

Method used

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  • Application of long non-coding RNA uc.48+ small interfering RNA in the preparation of drugs for diabetic neuropathic pain
  • Application of long non-coding RNA uc.48+ small interfering RNA in the preparation of drugs for diabetic neuropathic pain
  • Application of long non-coding RNA uc.48+ small interfering RNA in the preparation of drugs for diabetic neuropathic pain

Examples

Experimental program
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Effect test

Embodiment 1

[0019]Using methods known in the art, the oral or injected long non-coding ribonucleic acid uc.48+ small interfering RNA preparation suitable for the treatment of diabetic neuropathic pain is prepared.

Embodiment 2

[0021] The oral or injectable long non-coding ribonucleic acid uc.48+ small interfering RNA preparation suitable for the treatment of diabetes complicated with nerve injury-related diseases is prepared by methods known in the art.

Embodiment 3

[0023] Using methods known in the art, the oral or injected long non-coding ribonucleic acid uc.48+ small interfering RNA preparation suitable for the treatment of diabetes complicated with sensory neuroinflammation-related diseases is prepared.

[0024] In a word, long non-coding ribonucleic acid uc.48+ small interfering ribonucleic acid can be used for oral administration, injection, buccal tablet or other local or systemic dosage forms to prevent and treat the above-mentioned diseases.

[0025] In order to better understand the essence of the present invention, the following long non-coding ribonucleic acid uc.48+ small interfering ribonucleic acid pair P2X 3 Experiments and results of receptor-mediated treatment of related diseases to prove the use of long non-coding ribonucleic acid uc.48+ small interfering ribonucleic acid.

[0026] 1. Materials and methods.

[0027] 1. Animals and grouping.

[0028] Healthy Sprague-Dawley (SD) rats were provided by the Department of E...

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Abstract

The invention provides application of long non-coding RNA (Ribonucleic Acid) uc.48+ small interfering RNA to preparation of medicine for treating DM (Diabetes Mellitus) complicating neuropathic pain. Experiments prove that NONRATT021972 small interfering RNA can reduce the expression of a dorsal root ganglion neuron P2X3 receptor, can reduce the generation of a DM rat dorsal root ganglion cell inflammatory factor-TNF-alpha (Tumor Necrosis Factor-alpha), can inhibit the nociceptive information transmission of the dorsal root ganglion, can reduce the nociception stimulation of the nerve injury and inflammatory substances, can reduce the pain behavior of a rat with the type 2 DM neuropathic pain, and can be applied to the preparation of medicine for treating DM complicating neuropathic pain, DM complicating nerve injury relevant diseases and DM complicating nerve injury sensory nerve inflammatory diseases.

Description

technical field [0001] The present invention relates to the invention field of the drug application of diabetes complicated with neuropathic pain. Background technique [0002] Diabetes Mellitus (DM) is a group of metabolic clinical syndromes. With the development of society and the improvement of people's living standards, the prevalence of diabetes is increasing year by year. In developed countries, the prevalence of diabetes has reached 3%-7%. , has become the fourth priority disease after cancer, AIDS, and cardiovascular and cerebrovascular diseases, and has become the fifth leading cause of death in the world. Diabetes is divided into type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes. It is estimated that one in six people worldwide is at risk of complications from diabetes. Type 2 diabetes accounts for more than 90% of the diabetic population in my country, which seriously affects people's health and social development. Diabetic neuropathy is on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K48/00A61K31/713A61P3/10A61P25/00A61P29/00
Inventor 梁尚栋王寿玉吴炳邹丽芳刘双梅高云李桂林吴琴张熙应末凤
Owner NANCHANG UNIV
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