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Application of resveratrol in preparing medicines for treating human immunodeficiency virus glycoprotein 120 induced neuropathic pains

A technology for neuropathic pain and resveratrol, which is applied in the field of application of resveratrol in the preparation of human immunodeficiency virus glycoprotein 120-induced neuropathic pain drugs, which can solve the problems of high incidence and difficult treatment

Inactive Publication Date: 2017-03-08
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

High morbidity and unclear pathogenic preparations lead to extremely difficult treatment of HIV infection complicated with neuropathic pain, so it needs to be solved urgently

Method used

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  • Application of resveratrol in preparing medicines for treating human immunodeficiency virus glycoprotein 120 induced neuropathic pains
  • Application of resveratrol in preparing medicines for treating human immunodeficiency virus glycoprotein 120 induced neuropathic pains
  • Application of resveratrol in preparing medicines for treating human immunodeficiency virus glycoprotein 120 induced neuropathic pains

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Experimental program
Comparison scheme
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Embodiment 1

[0021] Oral or injectable resveratrol preparations suitable for the treatment of HIV gp120-induced neuropathic pain are prepared by methods known in the art.

Embodiment 2

[0023] Oral or injectable resveratrol preparations suitable for the treatment of diseases related to HIV gp120 complicated by nerve damage are prepared by methods known in the art.

Embodiment 3

[0025] Oral or injectable resveratrol preparations suitable for the treatment of HIV gp120 complicated with sensory neuroinflammation-related diseases are prepared by methods known in the technical field.

[0026] In a word, resveratrol can be used to prevent and treat the above-mentioned diseases by oral administration, injection, buccal tablet or other local or systemic dosage forms.

[0027] In order to better understand the essence of the present invention, below with resveratrol to P2X 7 Experiments and results of research on the therapeutic effect of receptor-mediated related diseases to prove the use of resveratrol.

[0028] 1. Materials and methods.

[0029] 1. Animals and grouping.

[0030] Thirty 200g Sprague-Dawley (SD) male rats were provided by the Laboratory Animal Science Department of Nanchang University School of Medicine. After one week of adaptation, they were randomly divided into 3 groups, 10 rats in each group: sham operation control group; HIV gp120 m...

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Abstract

The invention discloses an application of resveratrol in preparing medicines for treating human immunodeficiency virus glycoprotein 120 induced neuropathic pains. Experiments prove that the resveratrol can reduce the expression of a dorsal root ganglion satellite glial cell P2X7 receptor in a rat with the glycoprotein 120 induced neuropathic pains, reduce the expression of cell inflammatory factors, namely tumor necrosis factor-[alpha] and interleukin-1[beta], increase the expression of interleukin-10, reduce the phosphorylation of extracelluar regulated protein kinase and co-expression of glial fibrillary acidic protein and the P2X7 receptor, inhibit the noxious information transmission of dorsal root ganglion, relieve nerve injury and damage and irritation caused by inflammatory materials and relieve pain behaviors in the rat with the glycoprotein 120 induced neuropathic pains; therefore, the resveratrol can be used for preparing medicines for treating human immunodeficiency virus glycoprotein 120 related neuropathic pains and human immunodeficiency virus glycoprotein 120 nerve injury related diseases.

Description

technical field [0001] The present invention relates to the invention field of drug application of HIV gp120-induced neuropathic pain, in particular to the application of resveratrol in the preparation of drugs for reducing HIV gp120-induced neuropathic pain, and its mechanism of action involves inhibiting dorsal root ganglion purine 2X (P2X) 7 Receptor-mediated transmission of pain information. Background technique [0002] Human immunodeficiency virus (human immunodeficiency virus, HIV) infection often causes various nervous system-related diseases, leading to nervous system dysfunction, which seriously threatens life. With the development of the disease, HIV-infected patients are often accompanied by peripheral neuropathy, including peripheral sensory dysfunction, and further loss of walking function. Studies have shown that the injury of dorsal root ganglia (DRG) may lead to HIV infection complicated with peripheral neuropathy. Glycoprotein (glucoprotein120, gp120) is...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P25/00A61P29/00
CPCA61K31/05
Inventor 梁尚栋吴炳彭力超邹丽芳刘双梅易智华赵珊红贾天宇李桂林张春平
Owner NANCHANG UNIV
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