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P2x7 receptor antagonists,Heterocyclic derivatives as P2X7 receptor antagonists,Methods of detecting immune cells,N-arylbenzamide derivatives as P2X7 receptor antagonists

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4 results about "P2x7 receptor" patented technology

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P2X7 receptors are extracellular ATP-gated ion channels that play broad physiological and pathological roles in animals (Sluyter, 2017). Activation of P2X7 receptors lead to the opening of membrane channels permeable for small cations like Na + and Ca 2+ as well as fluorescent dyes such as YO-PRO-1 (Alves et al., 2014).

P2x7 receptor antagonists

PCT designated stageWO2026041663A1Senses disorderNervous disorderDiseasePharmaceutical medicine

Described herein are compounds of formula (I), where the substituents are disclosed herein, and exhibit antagonistic and / or inhibitory activity against the P2X7 receptor. These compounds, and their pharmaceutically acceptable salts, hydrates, solvates, and compositions thereof, are suitable for use in the prevention and treatment of diseases and conditions modulated by inhibition of the P2X7 receptor.

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Owner:BREYE THERAPEUTICS APS

Heterocyclic derivatives as P2X7 receptor antagonists

ActiveJP7871263B2Organic active ingredientsSenses disorderBiochemistryPharmacology

The present invention relates to novel 1,4-substituted piperidine compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties, pharmaceutical compositions containing these compounds, chemical processes for preparing these compounds, and their use in the treatment or prevention of diseases associated with P2X7 receptor activity in animals, particularly humans.