The invention discloses a vibration reduction device of mechanical equipment. Top bases are fixedly welded to the four corners of the bottom of a supporting base correspondingly, stable supports are arranged below the lower parts of the bottoms of the top bases, the top bases and the stable supports are fixedly connected through vibration reduction springs, vibration reduction air cylinders are fixedly connected to the middles of the top ends of the stable supports, and vibration reduction plug rods are installed at the positions, corresponding to the vibration reduction air cylinders, of themiddles of the bottom ends of the top bases. According to the vibration reduction device, through the top bases, the stable supports, the vibration reduction springs, the vibration reduction air cylinders and the vibration reduction plug rods, traditional vibration reduction springs are combined with the vibration reduction air cylinders and the vibration reduction plug rods for use, so that the vibration reduction effect of the supporting base in the vertical direction is further improved through the vibration reduction air cylinders and the vibration reduction plug rods during vibration reduction of the vibration reduction springs, meanwhile, a protective cover and an elastic band can shield and protect the outer sides of the vibration reduction springs, the vibration reduction air cylinders and the vibration reduction plug rods, and the vibration reduction springs, the vibration reduction air cylinders and the vibration reduction plug rods are prevented from being damaged by external environment factors.