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Use of long non-coding ribonucleic acid NONRATT021972 small interfering RNA in preparation of drug for treating diabetes mellitus with neuropathic pain

A technology of NONRATT021972, neuropathic pain, applied in the direction of nervous system diseases, drug combination, non-central analgesics, etc., can solve the problem that there are not many studies on long non-coding RNA

Active Publication Date: 2016-01-20
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, breakthroughs have been made in the research of non-coding RNAs (such as microRNA, siRNA and piRNA) with a length of less than 50 nucleotides, but there are not many studies on functional long non-coding RNAs

Method used

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  • Use of long non-coding ribonucleic acid NONRATT021972 small interfering RNA in preparation of drug for treating diabetes mellitus with neuropathic pain
  • Use of long non-coding ribonucleic acid NONRATT021972 small interfering RNA in preparation of drug for treating diabetes mellitus with neuropathic pain
  • Use of long non-coding ribonucleic acid NONRATT021972 small interfering RNA in preparation of drug for treating diabetes mellitus with neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The oral or injectable long noncoding ribonucleic acid NONRATT021972 small interfering RNA preparation suitable for the treatment of diabetic neuropathic pain was prepared by methods known in the art.

Embodiment 2

[0025] The oral or injectable long non-coding ribonucleic acid NONRATT021972 small interfering RNA preparation suitable for the treatment of diseases related to diabetes complicated with nerve injury was prepared by methods known in the art.

Embodiment 3

[0027] The oral or injectable long noncoding ribonucleic acid NONRATT021972 small interfering RNA preparation suitable for the treatment of diabetes complicated with sensory neuroinflammation-related diseases is prepared by methods known in the art.

[0028] In a word, long non-coding ribonucleic acid NONRATT021972 small interfering ribonucleic acid can be used for oral administration, injection, buccal tablet or other local or systemic dosage forms to prevent and treat the above diseases.

[0029] In order to better understand the essence of the present invention, the following long non-coding ribonucleic acid NONRATT021972 small interfering ribonucleic acid pair P2X 3 Experiments and results of receptor-mediated treatment of related diseases to prove the use of long non-coding ribonucleic acid NONRATT021972 small interfering ribonucleic acid.

[0030] 1. Materials and methods.

[0031] 1. Animals and grouping.

[0032] Healthy Sprague-Dawley (SD) rats were provided by the ...

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PUM

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Abstract

The invention discloses a use of a long non-coding ribonucleic acid NONRATT021972 small interfering RNA in preparation of a drug for treating diabetes mellitus with neuropathic pain. An experiment proves that the NONRATT021972 small interfering RNA can reduce dorsal root ganglion neuron P2X3 receptor expression, reduce diabetic rat serum cell inflammatory factor-tumor necrosis factor content, improve diabetic rat serum catalase and superoxide dismutase activity, inhibit dorsal root ganglion noxious information transmission, reduce nerve injury and inflammatory material damage stimulation, reduce diabetes mellitus type 2 rat neuropathic pain and be used for preparation of drugs for treating diabetes mellitus with neuropathic pain, diabetes mellitus with nerve injury related diseases, and diabetes mellitus with sensory nerve inflammatory diseases.

Description

technical field [0001] The present invention relates to the invention field of the drug application of diabetes complicated with neuropathic pain. Background technique [0002] Diabetes Mellitus (DM) is a group of metabolic clinical syndromes. With the development of society and the improvement of people's living standards, the prevalence of diabetes increases year by year. In developed countries, the prevalence of diabetes has reached 3%-7%. It has become the fourth priority disease after cancer, AIDS, and cardiovascular and cerebrovascular diseases, and has become the fifth leading cause of death in the world. Diabetes is divided into type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes. It is estimated that one in six people worldwide is at risk of complications from diabetes. Type 2 diabetes accounts for more than 90% of the diabetic population in my country, which seriously affects people's health and social development. Diabetic neuropathy is one o...

Claims

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Application Information

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IPC IPC(8): A61K48/00A61K31/7088A61P3/10A61P25/02A61P29/00
Inventor 梁尚栋彭海英李桂林刘双梅徐宏高云虞诗诚樊波
Owner NANCHANG UNIV
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