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Aseptic injectable material

A technology of vitamins and hyaluronic acid, which is applied in the fields of medical treatment and plastic surgery, and can solve problems such as poor plasticity and affecting applications

Active Publication Date: 2015-12-09
李媚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patented product is in a sol state. Although it has good ductility, it can be molded poorly, which affects the application in plastic surgery.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment one: rheological properties of hyaluronic acid gel containing different water-soluble vitamins

[0021] In this experiment, the rheological properties of hyaluronic acid gel containing water-soluble vitamins and hyaluronic acid without water-soluble vitamins before and after sterilization were compared, and the specific data are shown in Table 1.

[0022] For all samples from 1-1 to 1-14, the ratio of cross-linked hyaluronic acid gel to free hyaluronic acid solution is 7:3, the cross-linking agent is 1,4-butanediol glycidyl ether, and the cross-linking degree is 2.5 %, the residual amount of free 1,4-butanediol glycidyl ether is less than 1ppm. The concentration of hyaluronic acid is 15 mg / ml, the water is deionized water, and the pH value of the sample is 7.2. Among them, 1-1 was not sterilized, and other samples from 1-2 to 1-14 were all sterilized by moist heat at 121°C for 10 minutes. The test is carried out at 23°C.

[0023] Table 1.

[0024] ...

Embodiment 2

[0027] Embodiment 2: Rheological properties of hyaluronic acid gel containing different additives

[0028] In this experiment, the rheological properties of hyaluronic acid with different additives and no additives before and after sterilization were compared, and the specific data are shown in Table 2.

[0029] For all samples from 2-1 to 2-17, the ratio of cross-linked hyaluronic acid gel to free hyaluronic acid solution is 8:2, the cross-linking agent is 1,4-butanediol glycidyl ether, and the cross-linking degree is 5 %, the concentration of vitamin derivatives is 0.25mg / ml, the added concentration of dextran and lidocaine is 1% (W / W) and 0.1% (W / W) respectively, and the pH value of the sample is 7.1. Among them, 2-1 is not sterilized, and other samples from 2-2 to 2-17 are sterilized at 121°C for 10 minutes with moist heat. The test is carried out at 23°C.

[0030] Table 2.

[0031]

[0032] Table 2 shows that the addition of different combinations of water-soluble v...

Embodiment 3

[0033] Example 3: Properties of hyaluronic acid gels with different degrees of crosslinking

[0034] In this experiment, the rheological properties of hyaluronic acid gels with different cross-linking degrees after sterilization were compared, and the specific data are shown in Table 3.

[0035] For all samples from 3-1 to 3-18, the ratio of cross-linked hyaluronic acid gel to free hyaluronic acid solution was 9:1, the cross-linking agent was 1,4-butanediol glycidyl ether, and free 1,4- The residual amount of butanediol glycidyl ether is less than 1ppm. The concentration of hyaluronic acid gel is 22mg / ml, the concentration of vitamin derivative is 0.05mg / ml, and the concentration of dextran and lidocaine is 5% (W / W) and 3% (W / W) respectively. The pH value of the sample is 7.2. The samples from 3-1 to 3-19 are all sterilized by moist heat at 121°C for 20 minutes. The test is carried out at 23°C.

[0036] table 3.

[0037] Numbering

[0038] 3-1

[0039]...

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Abstract

The invention relates to an aseptic injectable material. The material is mainly composed of crosslinked hyaluronic acid gel, free hyaluronic acid, water-soluble vitamins and other compositions. The material is long in degradation period, high in plasticity, good in stability and high in flexibility, is applicable to hypodermics filling or skin restoration, operation anti-adhesion, articular cavity lubrication and the like, and belongs to the field of medical treatment and plastic and aesthetic surgery.

Description

technical field [0001] The invention relates to a sterile injectable material, which can be used for subcutaneous tissue filling or skin repair, operation anti-adhesion and joint cavity lubrication, etc., belonging to the fields of medical treatment and plastic surgery. Background technique [0002] Hyaluronic acid (Hyaluronic acid) is a polymer mucopolysaccharide composed of units D-glucuronic acid and N-acetylglucosamine. D-glucuronic acid and N-acetylglucosamine are connected by β-1,3-glycosidic bonds, and disaccharide units are connected by β-1,4-glycosidic bonds. Commercial hyaluronic acid is generally its sodium salt, that is, sodium hyaluronate (Sodium Hyaluronate), referred to as HA, and is still called hyaluronic acid in custom. With its unique molecular structure and physical and chemical properties, hyaluronic acid shows a variety of important physiological functions in the body, especially has a special water-retaining effect. It is the most moisturizing substan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08J3/24A61L27/20A61L27/52A61L27/60A61L31/04A61L31/14
Inventor 李媚
Owner 李媚
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