Application of Viburnum sargentii alcohol extract in preparation of NAFLD (non-alcoholic fatty liver disease) treatment drug

A non-alcoholic technology of Tianmu Qionghua alcohol, which is applied in the field of application of Tianmu Qionghua alcohol extract in the treatment of non-alcoholic fatty liver drugs, can solve the problems that patients are difficult to adhere to, and achieve small toxic and side effects, low cost, The effect of simple preparation method

Active Publication Date: 2015-12-23
TAISHAN MEDICAL UNIV
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  • Abstract
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AI Technical Summary

Problems solved by technology

At present, calorie restriction and exercise are the only effective means of treating NAFLD, but it is often diff

Method used

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  • Application of Viburnum sargentii alcohol extract in preparation of NAFLD (non-alcoholic fatty liver disease) treatment drug
  • Application of Viburnum sargentii alcohol extract in preparation of NAFLD (non-alcoholic fatty liver disease) treatment drug
  • Application of Viburnum sargentii alcohol extract in preparation of NAFLD (non-alcoholic fatty liver disease) treatment drug

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Experimental program
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Embodiment Construction

[0013] I. Materials and Methods

[0014] (1) Preparation of Alcoholic Extract of Tianmu Qionghua

[0015] The fruit of Tianmu Qionghua is collected from Mount Tai and identified by Professor Li Tongde, a senior expert in traditional Chinese medicine at Taishan Medical College. The fruit of Tianmu Qionghua is dried and ground, and 500g of the powder is extracted in 95% ethanol under reflux (m:v=1:10). The alcohol extract is filtered and concentrated into extract (3.49g crude drug / g), and the extract is prepared into 2.5g crude drug / ml, 5.0g crude drug / ml, 10.0g crude drug / ml with 5% sodium carboxymethylcellulose , stored at 4°C for later use.

[0016] (2) Grouping and handling of animals

[0017] 40 male apoE - / - Mice (18±22g, 7 weeks old) were purchased from Beijing Huafukang Biotechnology Co., Ltd., and were randomly divided into 5 groups after adaptive feeding for 1 week:

[0018] Model group (high-fat diet: 10% lard + 10% egg yolk powder + 0.30% cholesterol);

[0019]...

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Abstract

The invention relates to an application of a Viburnum sargentii alcohol extract in preparation of an NAFLD (non-alcoholic fatty liver disease) treatment drug. According to the application, a high fat diet induced apoE<-/->NAFLD model is adopted, simvastatin is taken as a positive control drug, after the Viburnum sargentii alcohol extract is taken orally for 8 weeks, the influence of the Viburnum sargentii alcohol extract on the NAFLD is observed and corresponding mechanism is explored; results show that the Viburnum sargentii alcohol extract improves high fat induced hepatic tissue pathological changes obviously, reduces damage of hepatocytes, reduces lipid accumulation in a liver and inhibits oxidative stress reaction in the liver. The novel application of the Viburnum sargentii alcohol extract is developed, and one novel way is provided for NAFLD treatment.

Description

technical field [0001] The invention relates to the field of application of Tianmu Qionghua, in particular to the application of Tianmu Qionghua ethanol extract in medicine for treating non-alcoholic fatty liver. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome with no history of excessive alcohol consumption but liver histological changes similar to alcoholic liver disease, which can develop into cirrhosis and liver cancer. In recent years, with the improvement of living standards, the incidence of NAFLD has been increasing year by year. About 14% to 24% of the general population suffer from NAFLD, which has become one of the most common liver diseases. At present, calorie restriction and exercise are the only effective means to treat NAFLD, but it is often difficult for most patients to persist. Therefore, it is necessary to find effective drugs for the treatment of NAFLD. Contents of the invention [0003] The purpose of th...

Claims

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Application Information

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IPC IPC(8): A61K36/35A61P1/16
Inventor 张颖秦树存张磊郭守东庞晓飞宋园园
Owner TAISHAN MEDICAL UNIV
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