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A kind of hepatitis B vaccine agonist composition and its application

A hepatitis B vaccine and agonist technology, applied in antiviral agents, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Active Publication Date: 2018-10-23
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the role of DC-SIGN in the immune response of hepatitis B vaccine, the effect of stimulating its high expression on the level of immune response, and the effect of combining with TLRs (TLR3 and TLR9) on the level of immune response to hepatitis B vaccine have not been reported at home and abroad

Method used

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  • A kind of hepatitis B vaccine agonist composition and its application
  • A kind of hepatitis B vaccine agonist composition and its application
  • A kind of hepatitis B vaccine agonist composition and its application

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0020] 1. The ingredients used:

[0021] (1)Le x -PAA-biotin (Lewisx-Polyacrylamide-biotin): Lewis-polyacrylamide-biotin, produced by GlycoTech, product number 01-036, polyacrylamide with a composition of 30kd contains 5% mole of biotin and 20% Moles of carbohydrates, which do not contain stabilizers and preservatives.

[0022] (2) Recombinant Saccharomyces cerevisiae Hepatitis B Vaccine (B201109009): Produced by Shenzhen Kangtai Biological Products Co., Ltd., it is made by purifying the hepatitis B virus surface antigen (HBsAg) expressed by recombinant Saccharomyces cerevisiae and adding aluminum adjuvant. It is a milky white suspension liquid, the active ingredient is HBsAg, and the excipients are aluminum hydroxide and sodium chloride. The specification is 20μg HBsAg / ml.

[0023] (3) PolyI:C (Polyinosinic acid-polycytidylic acid): that is, polyinosinic acid-polycytidylic acid: produced by Sigma Company in the United States, white powder, the specification is 1mg, and Pol...

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Abstract

The invention discloses a hepatitis B vaccine agonist composition and application thereof, and relates to a hepatitis B vaccine. The hepatitis B vaccine agonist composition comprises Lewisx-Polyacrylamide-biotin, polyinosinic acid-polycytidylic acid, and oligodeoxynucleotide, wherein the component of the Lewisx-Polyacrylamide-biotin is 30 kd polyacrylamide containing 5 mol% of biotin and 20 mol% of a carbohydrate; the sequence of the oligodeoxynucleotide is 5'-tcgacgttcgtcgttcgtcgttc-3', and the whole process is subjected to phosphorothioate modification. Through agonists of three receptors DC-SIGN, TLR3 and TLR9, high expression of corresponding acceptors are stimulated, so that the antigen presenting function of DC is improved, and Th1 immune response of a body is promoted.

Description

technical field [0001] The invention relates to hepatitis B vaccine, in particular to a hepatitis B vaccine agonist composition and application thereof. Background technique [0002] The World Health Organization reported that about 95% of newborns, infants and young adults who were fully vaccinated with hepatitis B vaccine according to the "0,1,6" immunization schedule can produce hepatitis B surface antibody (anti-HBs) to a protective level (anti-HBs≥ 10mIU / ml), but there are still 5-10% of individuals who cannot produce protective antibodies, and these people who cannot produce protective antibodies due to immunization failure are called hepatitis B vaccine non-responders (anti-HBs<10mIU / ml) . In addition, because the level of hepatitis B surface antibody will decrease as time goes by, those who were originally at the level of weak response to hepatitis B vaccine (10mIU / ml≤anti-HBs≤100mIU / ml), that is, weak responders to hepatitis B vaccine, may become hepatitis B vac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/39A61K39/29A61P31/20
Inventor 王素萍郭珍刘毅史晓红冯永亮陈卿苏通
Owner SHANXI MEDICAL UNIV
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