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Immunocompetent human placental polypeptide derived from hemoglobin

A technology of active peptides and hemoglobin, which is applied in the direction of hemoglobin/myoglobin, peptide/protein components, peptides, etc., and can solve the problems of reports on the immunostimulatory activity and use of hemoglobin immunoactive peptides that have not yet been discovered

Active Publication Date: 2020-12-25
SHINEWAY PHARMA GRP LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] No reports on the immunostimulatory activity and use of hemoglobin immunoreactive peptides have been found so far

Method used

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  • Immunocompetent human placental polypeptide derived from hemoglobin
  • Immunocompetent human placental polypeptide derived from hemoglobin
  • Immunocompetent human placental polypeptide derived from hemoglobin

Examples

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Embodiment

[0138] Hereinafter, the present invention will be described in more detail with reference to Examples. The following examples are further descriptions of the invention. It will be obvious to those skilled in the art to which the present invention belongs that these examples and descriptions are for illustrative purposes only, and do not constitute a limitation to the essence of the present invention.

[0139]Without further elaboration, all publications cited herein are hereby incorporated by reference in their entirety.

[0140] The experimental methods used in the following examples are conventional methods unless otherwise specified. The materials and reagents used in the following examples are commercially available unless otherwise specified.

[0141] 1. Obtaining human placenta material:

[0142] Maternal physical examination standards: Serological test of the patient, hepatitis B virus surface antigen (HBsAg) antibody test positive; hepatitis B virus (HBsAg, HBeAg, HB...

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Abstract

The invention relates to active polypeptides from a human placenta, which are derived from hemoglobin. The invention also relates to a composition comprising the polypeptides and application of the composition. A small-molecule substance with a molecular weight below 10KD in the human placenta is extracted from the human placenta by using a positive hepatitis B virus (HBV) surface antibody (HBsAb) to prepare injections including a liquid injection and a powder injection. According to the invention, the polypeptides in an extract are preliminarily analyzed by using a method of proteomics to obtain 5 types of human placental immunocompetent polypeptides derived from hemoglobin, and experimental studies show that the human placental immunocompetent polypeptides have immunological competence.

Description

technical field [0001] The invention relates to the field of biomedicine. Specifically, the present invention relates to active polypeptides derived from hemoglobin with immunologically active functions, compositions or preparations containing active polypeptides and active polypeptides, compositions or preparations containing active polypeptides are used in the preparation for the treatment of immune diseases, cancer and / or Application in drugs for hepatitis B and other diseases. Background technique [0002] The placenta is a transitional organ for the exchange of substances between mother and child formed by the joint growth of the embryonic membrane and the maternal endometrium during pregnancy in mammals. The placenta is composed of amniotic membrane, chorionfrondosum and decidua basalis. [0003] The composition of human placenta is more complex. It also contains interferon (interferon), which can inhibit the effect of various viruses on human cells, and contains ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/805C07K1/14C07K1/34A61K38/42A61P37/02A61P35/00A61P1/16A61P31/20
CPCA61K38/00C07K14/805
Inventor 王正品张浩军尹晓琳魏林张明正张霞李振江
Owner SHINEWAY PHARMA GRP LTD
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