A kind of Caragana plant bark ethyl acetate extract, extraction method and application

Abstract

The invention provides a caragana fabr. plant bark extract which is prepared by taking caragana fabr. plant bark as a raw material and performing extraction through ethyl acetate as a solvent. Pharmacological experiments prove that the extract is remarkable in antifungal effect and has potential clinical use value. After a supercritical CO2 extraction method is adopted to perform preliminary extraction on caragana fabr. plant bark, residue of the caragana fabr. plant bark is extracted through an organic solvent, and not only are the problems that a conventional organic solvent extraction method is low in efficiency and a poisonous solvent needs to be used are solved, but also useful components in the bark can be extracted and utilized to the largest extent.

Description

technical field [0001] The invention relates to an ethyl acetate extract of Caragana genus bark, an extraction method and application, and belongs to the field of medicine. Background technique [0002] Caragana Fabr. is a deciduous shrub. It is a typical vegetation in the Eurasian steppe plant subregion. It is mainly distributed in the dry area north of the Yellow River Basin in my country. Its cultivated species are generally called Caragana. At present, caragana is one of the important tree species for soil and water conservation and sand-fixing afforestation in Northwest my country, North China, and Northeast China, and it is also a good forage. [0003] Regarding the medicinal value of Caragana genus plants, traditional Chinese medicine believes that this genus plant has the functions of nourishing yin and blood, strengthening the spleen, and promoting blood circulation. , arthritis and gynecological diseases (Jia Minru et al., Chinese Ethnic Medicine [M], Beijing: Chi...

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Problems solved by technology

[0004] However, there are few reports on the pharmacological effects of the bark of this genus

Yang Zhongduo et al. isolated 7 compounds from the bark of Caragana ganmeneng, and determined the components with acetylcholinesterase inhibitory activity (Separation and structural identification of acetylcholinesterase inhibitors in Caragana ganmeneng[J], Lanzhou Journal of Polytechnic University, 2015, 41:78-80), the extraction method used is the traditional organic solvent extraction method, which takes a long time and requires the use of toxic solvents such as chloroform

[0005] Caragana (C.korshinskii Kom.) is a perennial deciduous shrub belonging to the genus Caragana. At present, research on it mainly focuses on physiological and ecological effects, feed development and utilization, and energy. So far, there is no public report about the bark extract of this plant

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