Application of TPO (thrombopoietin) receptor agonist in promoting homing of HSCs (hematopoietic stem cells)

A thrombopoietin and receptor agonist technology, which is applied in the field of promoting hematopoietic stem cell homing and thrombopoietin receptor agonist, can solve the problems that the drug needs further research and achieve the effect of improving the homing efficiency

Inactive Publication Date: 2016-03-23
SOUTH CHINA INSTITUDE OF BIOMEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, at present, there is no drug used clinically to promote the homing of hematopoietic stem cells after hematopoietic stem cell transplantation, and the drugs used in this field need further research

Method used

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  • Application of TPO (thrombopoietin) receptor agonist in promoting homing of HSCs (hematopoietic stem cells)
  • Application of TPO (thrombopoietin) receptor agonist in promoting homing of HSCs (hematopoietic stem cells)
  • Application of TPO (thrombopoietin) receptor agonist in promoting homing of HSCs (hematopoietic stem cells)

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Experimental program
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Embodiment 1

[0038] The effect of the thrombopoietin receptor agonist eltrombopag on hematopoietic stem cell homing after bone marrow cell transplantation was examined as follows:

[0039] 1. Isolation of mouse bone marrow cells

[0040] C57BL / 45.1 strain mice were purchased from Beijing Huafukang Biotechnology Co., Ltd., 6-8 weeks old, 18-22g body weight, male, and these mice were used as bone marrow cell transplantation donors. The early hematopoietic stem progenitor cells and leukocytes of this mouse stably express CD45.1, and are used in competitive transplantation experiments together with C57BL / 45.2 strain mice. The mice were in a stable state for more than one week, and then sacrificed by spinal dislocation. The femur and tibia were taken out, and the bone marrow cavity was washed repeatedly with PBS. TM LysingSolution, CAT.No: 55899, dilute with deionized water 1:10 before use), add an equal volume of PBS after 2 minutes, centrifuge at 600g for 5 minutes, and wash twice to obtain ...

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Abstract

The invention discloses an application of a TPO (thrombopoietin) receptor agonist in promoting homing of HSCs (hematopoietic stem cells). The TPO receptor agonist can effectively promote homing of the HSCs after a bone marrow transplantation operation and further can be effectively used for preparation of a drug for promoting homing of the HSCs. The drug can increase the number of the homing HSCs and improve the homing efficiency of the HSCs and further can promote implantation of the HSCs and increase the success rate of transplantation of bone marrow HSCs.

Description

[0001] priority information [0002] This application claims the priority and rights of the patent application No. 201510483901.5 submitted to the State Intellectual Property Office of China on August 07, 2015, and the entirety of which is hereby incorporated by reference. technical field [0003] The invention relates to the field of biopharmaceuticals, in particular to the use of a thrombopoietin receptor agonist in promoting homing of hematopoietic stem cells. Background technique [0004] Hematopoietic stem cell (Hematopoietic stem cells, HSC) transplantation has become one of the important methods for the clinical treatment of various malignant hematological diseases and immunodeficiency diseases. After transplantation, hematopoietic stem cells will return to the recipient's hematopoietic microenvironment through the blood circulation, proliferate and differentiate, and rebuild the recipient's hematopoietic and immune system, so as to achieve the purpose of treatment. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/4152A61P7/00A61P37/02
CPCA61K45/00A61K31/4152
Inventor 裴雪涛李艳华邓子亮刘一鸣韩毅
Owner SOUTH CHINA INSTITUDE OF BIOMEDICINE
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