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A crystal form a of compound 3 (2-acetamido-acetamido)-propionic acid and its preparation method and application

An acetamide-based compound technology, applied to the crystal form A of the compound 3-propionic acid and its preparation, the crystal form A can solve the practical application and storage limitations in the non-therapeutic whitening field, and the purification method of propionic acid has not been disclosed , stability, solubility and other properties have not been discussed, and the steps are easy to operate, good thermal stability and storage stability, and are conducive to the effect of process production

Active Publication Date: 2017-10-24
CORUM
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Problems solved by technology

[0005] However, Example 1 of CN 103298778A only discloses the white powder of 3(2-acetamido-acetamido)-propionic acid obtained by vacuum evaporation of the filtrate, and the purity of the powder analyzed by liquid chromatography is only greater than 95%. %, but CN103298778A did not disclose the relevant purification method of 3(2-acetamido-acetamido)-propionic acid, and did not discuss the crystal form, stability and solubility of its powder, resulting in compound 3( The practical application and storage of 2-acetamido-acetamido)-propionic acid in skin whitening related industries are greatly restricted

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  • A crystal form a of compound 3 (2-acetamido-acetamido)-propionic acid and its preparation method and application
  • A crystal form a of compound 3 (2-acetamido-acetamido)-propionic acid and its preparation method and application
  • A crystal form a of compound 3 (2-acetamido-acetamido)-propionic acid and its preparation method and application

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Embodiment Construction

[0054] For further elaborating the technical means and effects that the present invention takes to reach the intended invention purpose, below in conjunction with accompanying drawing and preferred embodiment, a kind of compound 3 (2-acetamido-acetamido) that proposes according to the present invention -The crystal form A of propionic acid and its preparation method and application, its specific implementation, structure, method, steps, characteristics and efficacy, are described in detail below.

[0055] According to an embodiment provided by the present invention, the crystal form A of the compound 3 (2-acetamido-acetamido)-propionic acid used for inhibiting melanin production, the powder X-ray diffraction pattern of the crystal form A Such as figure 1 As shown, including the following diffraction peaks expressed in 2θ angles: 10.4±0.2°, 11.0±0.2°, 12.9±0.2°, 16.0±0.2°, 16.4±0.2°, 17.6±0.2°, 19.1±0.2°, 19.5±0.2° 0.2°, 20.0±0.2°, 21.2±0.2°, 23.2±0.2°, 23.5±0.2°, 24.1±0.2°, 2...

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Abstract

The present invention relates to a crystal form A of compound 3(2-acetamido-acetamido)-propionic acid used for inhibiting melanin production and its preparation method and application. The crystal form A of the compound 3 (2-acetamido-acetamido)-propionic acid provided by the present invention has high purity and good thermal stability. Moreover, the preparation method provided by the present invention uses a low-toxic alcohol solvent, the conditions are mild, and the crystal form of 3(2-acetamido-acetamido)-propionic acid with high purity and good reproducibility can be obtained a. The crystal form A of the above-mentioned compound 3 (2-acetamido-acetamido)-propionic acid can be used for non-therapeutic skin whitening.

Description

technical field [0001] The invention belongs to the field of active ingredients for skin whitening, in particular to a crystal form A of compound 3(2-acetamido-acetamido)-propionic acid and its preparation method and application of compound 3(2-acetamido) -Acetamido)-propionic acid in form A of whitening method for non-therapeutic use. Background technique [0002] In epidermal cells, tyrosine, the precursor of melanin, naturally exists in the melanin production reaction process through tyrosine → Dopa → Dopaquinone → Dopachrome → melanin , Tyrosinase is an important enzyme that converts tyrosine into dopa through its hydroxylase activity, and converts dopa into dopaquinone through its oxidase activity. Therefore, as long as it can effectively act on epidermal melanocytes, inhibit melanogenesis, or inhibit any process of melanin biosynthesis, it can be used as an active ingredient for skin whitening. [0003] CN 103298778A has disclosed a compound 3 (2-acetamido-acetamido)...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C237/22C07C231/24A61K8/44A61Q19/02
Inventor 徐迺璿
Owner CORUM
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