Multi-fiber tablet sheet body cementing composite auxiliary material and application thereof

A multi-fiber easily cracked and excipient technology, applied in the field of biomedicine, can solve problems such as inability to press tablets, achieve good stability, solve stomach discomfort, and be suitable for a wide range of people.

Active Publication Date: 2016-05-04
JILIN MODERN TRADITIONAL CHINESE MEDICINE ENG RES CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention can be used in the preparation process of traditional Chinese medicine powder such as fungus powder, white fungus powder, cordyceps sin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Cordyceps tablets take 35 parts of microcrystalline cellulose, 50g of fine powder of Cordyceps sinensis mycelium, 7 parts of corn protein, 5 parts of cross-linked povidone, 5 parts of silicon dioxide, 1 part of magnesium stearate, 0.5 parts of magnesium stearate. Make 1000 pieces, 0.6g / piece The Cordyceps tablet finished product of the above-mentioned embodiment was carried out according to the "Chinese Pharmacopoeia" 2010 edition, and the quality inspection items of the tablet were carried out: appearance properties, difference in tablet weight, hardness and friability, disintegration, and content uniformity.

[0018] The inspection results are as follows

[0019] test result

[0020] 1. Appearance properties: complete and smooth, uniform color, no foreign matter, no spots.

[0021] 2. Difference in tablet weight: Take 20 tablets and weigh them, compare the weight of each tablet with the average tablet weight, and there is no tablet exceeding the difference limit.

...

Embodiment 2

[0025] Embodiment 2 Broken ganoderma lucidum spore sheet

[0026] Get 50 parts of microcrystalline cellulose, 40 parts of Ganoderma lucidum spore powder, 6 parts of zein 6 parts of crospovidone, 1 part of silicon dioxide, 1.5 parts of magnesium stearate and make 1000 pieces, 0.6g / piece takes the broken powder of the above-mentioned embodiment According to the 2010 edition of "Chinese Pharmacopoeia", the finished products of Bi Ganoderma lucidum spore tablets are subject to quality inspection items: appearance, tablet weight difference, hardness and friability, disintegration, and content uniformity.

[0027] The inspection results are as follows

[0028] test result

[0029] 2. Appearance properties: complete and smooth, uniform color, no foreign matter, no spots.

[0030] 3. Difference in tablet weight: Take 20 tablets and weigh them, compare the weight of each tablet with the average tablet weight, and there is no tablet exceeding the difference limit.

[0031] 4. Hardnes...

Embodiment 3 10

[0035] Get 38 parts of microcrystalline cellulose, 48 parts of Panax notoginseng powder, 7 parts of zein crospovidone, 6 parts of silicon dioxide, 1 part of magnesium stearate and 0.6 part to make 1000 pieces, 0.7g / piece takes the above-mentioned embodiment The finished products of Cordyceps Tablets are in accordance with the 2010 edition of the Chinese Pharmacopoeia, and the quality inspection items of the tablets are carried out: appearance, tablet weight difference, hardness and friability, disintegration, and content uniformity.

[0036] The inspection results are as follows

[0037] test result

[0038] 1. Appearance properties: complete and smooth, uniform color, no foreign matter, no spots.

[0039] 2. Difference in tablet weight: Take 20 tablets and weigh them, compare the weight of each tablet with the average tablet weight, and there is no tablet exceeding the difference limit.

[0040] 3. Hardness and friability: the hardness of the tablet measured by the Monsant...

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Abstract

The invention discloses an auxiliary material composition, which is prepared from microcrystalline cellulose, zein, polyvinylpolypyrrolidone, silicon dioxide and magnesium stearate in a weight ratio of (30-80) to (5-15) to (4-10) to (0.5-2) to (0.1-1.5). The auxiliary material composition can be used in most hard-to-shape traditional Chinese medicine powder to prepare granules, the granules are good in mobility, strong in compressibility, and good in lubricating effect, and pressed tablets are smooth in surface and good in hardness, and fast in disintegrating, thereby solving the difficulty that most traditional Chinese powder is hard to tablet.

Description

technical field [0001] The invention provides a multi-fiber tablet body cementing composite auxiliary material. It belongs to the field of biomedicine. Background technique [0002] The composition of traditional Chinese medicine is complex. If the properties of Chinese medicinal materials are not analyzed in detail, all of them are ground into fine powder, and then added with adhesive to shape, it will bring difficulties to tablet compression. The following two situations are more prominent: 1. The excessive cellulose content of the fine powder of traditional Chinese medicine and its own structural characteristics make the powder have certain elasticity. When the tablet is pressed, it will not be bonded, resulting in loose sheets and splits. The fine powder of medicinal materials in the second preparation does not contain fibers and is all extracted into extracts, and the extracts are dried and crushed into extract powders, and most of these extract powders contain highly...

Claims

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Application Information

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IPC IPC(8): A61K47/38A61K47/32A61K47/04A61K47/12A61K47/42A61K9/20A61K36/068A61K36/074A61K36/258A61K36/07A61K36/06
CPCA61K9/2009A61K9/2013A61K9/2027A61K9/2054A61K9/2063A61K36/06A61K36/068A61K36/07A61K36/074A61K36/258A61K2300/00
Inventor 张江周立梅王莲萍邹慧候宝赵全成杨磊张金秋
Owner JILIN MODERN TRADITIONAL CHINESE MEDICINE ENG RES CENT
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