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A method for organ arrest, protection and preservation and reducing tissue injury

A composition, technology of adenosine receptors, applied to tissues and cells, to rejuvenate and resuscitate these organs, to reduce the deleterious effects of surgical or clinical interventions on damaged organs throughout the body, to prepare the field of organs for receptors, capable of resolving stasis And other issues

Inactive Publication Date: 2016-05-11
低温药理KF有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there are no effective goal-directed or holistic therapeutic strategies to arrest the heart and preserve the body's organs, tissue cells during cardiac surgery or organ transplantation

Method used

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  • A method for organ arrest, protection and preservation and reducing tissue injury
  • A method for organ arrest, protection and preservation and reducing tissue injury
  • A method for organ arrest, protection and preservation and reducing tissue injury

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Embodiment Construction

[0102] The present invention relates to methods of inducing organ arrest, maintaining arrest, and resuscitation in a subject who has experienced a life-threatening disease or injury, the method comprising administering to the subject (i) a compound selected from at least one of the following : potassium channel openers, potassium channel agonists, and adenosine receptor agonists; (ii) antiarrhythmic agents or local anesthetics; and (iii) citrate. Preferably, the method comprises administering an elevated source of magnesium ions. The method may further comprise administering insulin, general anesthetics, mitochondrial pore inhibitors, myosin ATPase inhibitors, and / or anti-inflammatory agents to improve function. The invention also relates to compositions for use in these methods and pharmaceutical formulations suitable for such treatments.

[0103] The present invention also provides a method for preparing, obtaining and storing organs, tissues and cells, the method comprisin...

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Abstract

The invention relates to compositions and methods for Inducing organ arrest, maintaining arrest and reanimating in a subject that has suffered a life threatening disease or injury; preparing, harvesting, storing organs, tissues and cells; reducing the harmful effects of at least one of anaesthesia, surgery, clinical intervention, and cardiopulmonary bypass on injuring the tissues, organs and cells of a subject; or reducing the harmful effects of surgery or clinical intervention on injuring the organs and brain in the whole body of a subject. The composition comprises (i) a compound selected from at least one of a potassium channel opener, a potassium channel agonist and an adenosine receptor agonist; (ii) an antiarrhythmic agent or a local anaesthetic; and (iii) citrate.

Description

technical field [0001] The present invention relates to a method of inducing organ arrest, maintaining arrest, and resuscitation in a subject who has experienced a life-threatening disease or injury. The present invention also relates to a method of inducing cardioplegic arrest, maintaining arrest, and post-arrest resuscitation in a subject in need of elective normal, high risk, or emergency surgery. The present invention also relates to a method of inducing cardioplegic arrest, maintaining arrest, and resuscitation in a subject in need of elective or emergency organ transplantation. The present invention also relates to methods and compositions for preparing clinically dead donor subjects to preserve and obtain body organs, tissues and cells for transplantation. The invention also relates to methods for storing organs, tissues and cells obtained from donors for recipients. The invention also relates to methods for rewarming and resuscitating these organs after storage and p...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61K31/167A61K31/194A01N1/02A61P9/06A61P9/10
CPCA61K31/167A61K31/519A61K45/06A61K31/7004A61K9/0019A61K47/26A61K31/7076A61K33/06A61P17/02A61P23/00A61P23/02A61P25/04A61P25/20A61P29/00A61P41/00A61P7/02A61P7/08A61P9/06A61P9/10A61K2300/00A61K31/194A61K9/08A61K31/05A61K31/19
Inventor 杰弗里·多布森
Owner 低温药理KF有限公司
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