Isoliquiritigenin nicotinamide eutectic crystal and preparation method thereof

A technology of isoliquiritigenin and nicotinamide, which is applied in the field of drug co-crystals, can solve the problems of low usage rate, achieve the effects of increased yield, simple preparation process, and low cost

Inactive Publication Date: 2016-06-15
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are only 10 kinds of acidic coordination molecules that can be used for salt formatio

Method used

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  • Isoliquiritigenin nicotinamide eutectic crystal and preparation method thereof
  • Isoliquiritigenin nicotinamide eutectic crystal and preparation method thereof
  • Isoliquiritigenin nicotinamide eutectic crystal and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]Precisely weigh 54.18 mg of isoliquiritigenin and 25.82 mg of nicotinamide and mix them in an agate mortar, add 65 μl of methanol, grind at room temperature for 10 minutes and collect to obtain isoliquiritigenin nicotinamide co-crystal.

Embodiment 2

[0030] Precisely weigh 100.51 mg of isoliquiritigenin and 47.91 mg of nicotinamide and mix them in an agate mortar, add 100 μl of ethanol, grind at room temperature for 15 minutes and collect to obtain isoliquiritigenin nicotinamide cocrystal.

Embodiment 3

[0032] Precisely weigh 60.17 mg of isoliquiritigenin and 28.53 mg of nicotinamide into a mortar, add 75 μl of methanol, and grind for 30 minutes to obtain isoliquiritigenin nicotinamide co-crystal.

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PUM

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Abstract

The invention belongs to the technical field of medicine eutectic crystals, and concretely discloses an isoliquiritigenin nicotinamide eutectic crystal and a preparation method thereof. The above medicinal eutectic crystal preparation method adopts isoliquiritigenin as a medicinal active component and nicotinamide as an eutectic precursor, and adopts a solvent assisted grinding technology or a solvent suspension technology to crystallize, and the obtained eutectic crystal has a brand new crystallization form, and is completely different from isoliquiritigenin and nicotinamide crystals in characteristics.

Description

technical field [0001] The invention belongs to the technical field of drug co-crystals, and in particular relates to isoliquiritigenin nicotinamide co-crystals and a preparation method thereof. Background technique [0002] Supramolecular chemistry was first proposed by French scientist Jean-Marie Lehn in 1987. It is based on intermolecular non-covalent bonds, and it targets supramolecular and molecular aggregates. It is a study of molecular assembly and intermolecular bonds. Subject. It mainly studies the non-covalent bond interaction between different kinds of molecules, and its core content is molecular recognition, that is, the process of optimal matching between the subject and the substrate molecule to form a secondary bond, which is the embodiment of the synergistic summation of non-covalent bond weak interactions ; Supramolecular self-assembly refers to the process in which building blocks spontaneously form ordered structures under certain conditions, and is an im...

Claims

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Application Information

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IPC IPC(8): C07D213/82C07C49/835C07C45/81
CPCC07D213/82C07B2200/13C07C45/81C07C49/835
Inventor 蔡挺秦昆明黄雨婷徐嘉蔡宝昌
Owner CHINA PHARM UNIV
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