Betaxolol containing pharmaceutical composition for treating hypertension and preparation method thereof

A composition and technology for hypertension, applied in the field of medicine, can solve problems such as restricting the use of betaxolol, and achieve the effects of avoiding adverse reactions, lowering blood pressure, and improving therapeutic effects

Inactive Publication Date: 2016-06-22
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This adverse reaction limits the clinical use of betaxolol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0038] Betaxolol 10g, Prunella vulgaris 3000g, Camellia 3000g, Tea tree root 3000g, Guizhi 3000g.

[0039] The preparation method of the pharmaceutical composition for treating hypertension:

[0040] a. Add water to decoct Prunella vulgaris Prunella, camellia, tea tree root, and cinnamon sticks for 2 times. Add 7 volumes of water for the first time and decoct for 1.5 hours. Add water 5 times the volume of the medicine for the second time and decoct for 1 hour. , combine the decoction, set aside;

[0041] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0042] c. mixing betaxolol with dry po...

Embodiment 2

[0046] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0047] Betaxolol 7.5g, Prunella vulgaris 3500g, Camellia 2500g, Tea tree root 3500g, Guizhi 2500g.

[0048] The preparation method of the pharmaceutical composition for treating hypertension:

[0049] a. Add water to decoct Prunella vulgaris Prunella, camellia, tea tree root, and cinnamon sticks for 2 times, add 8 volumes of water for the first time, decoct for 2 hours, add water 6 times the volume of the medicine for the second time, and decoct for 1.5 hours , combine the decoction, set aside;

[0050] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0051] c. mixing betaxolol with dry pow...

Embodiment 3

[0055] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0056] Betaxolol 12.5g, Prunella vulgaris 2500g, Camellia 3500g, Tea tree root 2500g, Guizhi 3500g.

[0057] The preparation method of the pharmaceutical composition for treating hypertension:

[0058] a. Add Prunella vulgaris, camellia, tea tree root, and cinnamon sticks to decoct twice, add 6 volumes of water for the first time, decoct for 1 hour, add water 4 times the volume of the medicine for the second time, and decoct for 0.5 hours , combine the decoction, set aside;

[0059] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0060] c. mixing betaxolol with dry powder, and granulating ...

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PUM

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Abstract

The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing betaxolol for treating hypertension and a preparation method thereof. The pharmaceutical composition for treating high blood pressure containing betaxolol of the present invention is composed of the raw materials in the following proportions by weight: 5-15 parts of betaxolol, 2000-4000 parts of Prunella vulgaris, 2000-4000 parts of camellia , 2000-4000 parts of tea tree root, 2000-4000 parts of cinnamon stick. The invention combines traditional Chinese medicine with betaxolol, can avoid common adverse reactions of betaxolol, and improve the therapeutic effect on hypertension.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing betaxolol for treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is an important etiology and risk factor of cardiovascular and cerebrovascular diseases, and 20%-30% of people worldwide suffer from hypertension. High blood pressure can affect the structure and function of the heart, brain, and kidney, and significantly increase the risk of stroke, heart failure, and end-stage renal disease. Essential hypertension accounts for 95% of the incidence of hypertension. The survey in 2002 showed that the prevalence rate of people over the age of 18 in my country was as high as 18.8%, and the number of patients reached 160 million. Therefore, the prevention and treatment of hypertension has become a major public health issue that is of the greatest concern in my country and the world. ...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/82A61K9/16A61K31/138A61P9/12
CPCA61K31/138A61K9/1652A61K36/53A61K36/54A61K36/82A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor不公告发明人
OwnerJINAN BANGWEN MEDICAL TECH