A kind of method for preparing pure powder tablet of Cordyceps sinensis under low pressure

A technology for Cordyceps sinensis micropowder and Cordyceps sinensis Cordyceps sinensis, which is applied in the field of preparing qualified Cordyceps sinensis pure powder tablets, can solve problems such as inability to prepare qualified Cordyceps sinensis pure powder tablets, and achieves the effects of short disintegration time limit, good dissolution rate and large total pore area

Active Publication Date: 2020-04-14
熊建民
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is: to overcome the deficiency that qualified Cordyceps pure powder tablets cannot be prepared by low-pressure pressing in the preparation process of Cordyceps pure powder tablets, and to provide a method for preparing Cordyceps pure powder tablets under low pressure conditions

Method used

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  • A kind of method for preparing pure powder tablet of Cordyceps sinensis under low pressure
  • A kind of method for preparing pure powder tablet of Cordyceps sinensis under low pressure
  • A kind of method for preparing pure powder tablet of Cordyceps sinensis under low pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]The concrete preparation method of this example is as follows:

[0032] (1): Grinding the Cordyceps sinensis grass with a water content of less than 8% to a powder with a particle size of 48-75 μm, and pressing the Cordyceps sinensis powder under the condition of controlling the tableting pressure to 0.45kN by dry pressing at room temperature. Tablets with a diameter of 10 mm;

[0033] (2) the above-mentioned prepared Cordyceps tablet is placed in a water vapor environment with a vapor pressure of about 20kPa to absorb water for 12 hours, so that the adsorption capacity of the Cordyceps tablet to water is 27.2% of its own weight;

[0034] (3) Immediately put the Cordyceps sinensis tablet after water absorption into the environment of -5 ℃ and freeze for 10 hours, until all the liquid water in the sample forms solid ice;

[0035] (4) Freeze-dry the frozen tablet at a temperature of -25° C. until constant weight.

[0036] Sample analysis:

[0037] 1. Linear inspection o...

Embodiment 2

[0059] The concrete preparation method of this example is as follows:

[0060] (1): Grinding the Cordyceps sinensis grass with a water content of less than 8% to a powder with a particle size of 58-150 μm, and pressing the Cordyceps sinensis powder under the condition of controlling the tableting pressure to 2.25kN by dry pressing at room temperature. Tablets with a diameter of 10 mm.

[0061] (2) The Cordyceps tablet prepared above was placed in a water vapor environment with a vapor pressure of about 15kPa to absorb water for 12 hours, so that the adsorption capacity of the Cordyceps tablet to water was 41.7% of its own weight.

[0062] (3) Immediately freeze the Cordyceps sinensis tablet after absorbing water in an environment of -5° C. for 12 hours, until all the liquid water in the sample forms solid ice.

[0063] (4) Freeze-dry the frozen tablet to a constant weight at a temperature set at -25°C.

[0064] Sample analysis:

[0065] 1. Tablet hardness test

[0066] Fir...

Embodiment 3

[0078] The concrete preparation method of this example is as follows:

[0079](1): Grinding the Cordyceps sinensis grass with a water content of less than 8% to a powder with a particle size of 25-38 μm, and pressing the Cordyceps sinensis powder under the condition of controlling the tableting pressure to 4.95kN by dry pressing at room temperature. Tablets with a diameter of 10 mm.

[0080] (2) The Cordyceps tablet prepared above was placed in a water vapor environment with a vapor pressure of about 10 kPa to absorb water for 12 hours, so that the adsorption capacity of the Cordyceps tablet to water was 22.7% of its own weight.

[0081] (3) Immediately freeze the Cordyceps sinensis tablet after absorbing water in a -5°C environment for 24 hours, until all the liquid water in the sample forms solid ice.

[0082] (4) Freeze-dry the frozen tablet to a constant weight at a temperature set at -25°C.

[0083] Sample analysis:

[0084] 1. Tablet hardness test

[0085] First adop...

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Abstract

The invention discloses a method for preparing cordyceps sinensis-containing pure powder tablets under low pressure, belonging to the fields of medicines and health care products. The method provided by the invention adopts cordyceps sinensis original grass with water content less than 8% to prepare micro powder, and comprises the steps of carrying out dry tableting under a condition of 0.1-25kN, enabling the prepared tablets to absorb a certain amount of solvent in a liquid vapor environment of water, an ethyl alcohol solvent or an ethyl acetate solvent, then freezing the tablets under a condition of the temperature being below a melting point of the absorbed solvent, and finally, carrying out freeze drying on the frozen samples to obtain the cordyceps sinensis-containing pure powder tablets. The appearance shapes and parameters such as hardness of the cordyceps sinensis-containing tablets are improved while the quality of the prepared tablets meets a tablet quality standard, the tableting pressure in the existing cordyceps sinensis-containing tablet processing technology is greatly reduced, pore channel structures in the tablets are greatly improved, and the pore volumes, pore areas and porosities of the interiors of the tablets are improved. The tablets prepared by the technology are good in appearance and high in yield, the hardness, frangibility and disintegration of the tablets are in accordance with tablet quality requirements, and relevant parameters of the cordyceps sinensis-containing pure powder tablets prepared by the method are better than those of cordyceps sinensis-containing tablets prepared by the existing high-pressure dry powder tablet processing technology.

Description

technical field [0001] The invention belongs to the technical field of medicine and health care products, in particular to the technology of preparing qualified pure powder tablets of Cordyceps sinensis through low-pressure compression, absorption of a controllable solvent and freeze-drying. Background technique [0002] Cordyceps sinensis (Cordyceps sinensis) is a complex of subunits and larval corpses of the fungus Cordyceps sinensis of the family Ergotaceae of the order Hypocreales, which parasitizes on the larvae of the genus Batmothidae of the family Lepidoptera. It is mainly distributed in the southwest of the Qinghai-Tibet Plateau in China, Denmark, Nepal and India are on the plateau at an altitude of 3500-5000 meters above sea level. Through the development of modern medicine, it has been proved that it has the effects of anti-cancer, immune regulation, anti-oxidation, anti-aging and anti-diabetes. It is recorded in the Chinese "Materia Medica Cong Xin" that it has t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/068A23L33/105A23L31/00
CPCA61K9/2095A61K36/068
Inventor 熊建民曾桂凤王鲁熊斌斌
Owner 熊建民
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