Crystal form D of anisodine hydrobromide as well as preparation method and use of crystal form D

A kind of technology of anisodine hydrobromide and crystal form, applied in the crystal form D of anisodine hydrobromide and the field of preparation and use thereof, can solve the problem that no patent discloses the preparation method of anisodine hydrobromide crystal form, etc. problem, to achieve the effects of low cost, good stability, and simple operation of the preparation process
CN105820164AInactive Publication Date: 2016-08-03CHENGDU FIRST PHARMA DRUG SUBSTANCE CO LTD
4 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHENGDU FIRST PHARMA DRUG SUBSTANCE CO LTD
Publication Date
2016-08-03
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a novel crystal form of anisodine hydrobromide and a preparation method of the novel crystal form. The novel crystal form of anisodine hydrobromide is named as a crystal form D. The crystal form has the beneficial effects that the stability is good, the solubility and the hygroscopicity meet pharmaceutical requirements, a preparation process is simple in operation and low in cost, and the crystal form has important value to the optimization and development of drugs in future. The crystal form can be used for preparing preparations of drugs for treating hemicranias, vascular headache, retinal vascular spasm, ischemic optic neuropathy, nervous system inflammation and acute paralysis, paralysis agitans, depression and the like caused by blood vessels of brain.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a new crystal form of anisodine hydrobromide, a preparation method and application thereof. Background technique

[0002] Anisodine is a new anticholinergic drug extracted from the plant Anisodina tangutica. It is the first isolated cholinergic receptor blocker in my country. Its hydrobromide is mainly used clinically. Anisodine hydrobromide can be used to treat migraine, vascular headache, retinal vasospasm, ischemic optic neuropathy, nervous system inflammation and acute paralysis caused by cerebrovascular, paralysis agitans, depression, etc. It can also be used for organophosphate Detoxification of ester pesticide poisoning. Clinically used anisodine preparations include tablets, injections and film preparations, etc. These preparations have certain deficiencies in terms of stability, dissolution rate, etc., while playing a positive clinical therapeutic role. The structure of anisodine is shown in formula (I).

[0003] ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More