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Bio-enzyme-wrapped microparticle and preparation method and application thereof

A biological enzyme and encapsulation technology, applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of reducing product efficacy, enzyme inactivation, inactivation, etc., to achieve improved retention time, good whitening effect, and effective Good results

Active Publication Date: 2016-08-31
广东百润和健康科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0018] Enzymes in oral care products are easily inactivated by temperature and other ingredients in the formula, especially ionic surfactants commonly used in oral care products, such as sodium lauryl sulfate, etc.; chelating agents, such as polyphosphate etc.; ingredients such as preservatives and flavors will lead to the inactivation of enzymes in the formula and reduce the efficacy of the product

Method used

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  • Bio-enzyme-wrapped microparticle and preparation method and application thereof
  • Bio-enzyme-wrapped microparticle and preparation method and application thereof
  • Bio-enzyme-wrapped microparticle and preparation method and application thereof

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Embodiment

[0070] The preparation process of microparticles encapsulating biological enzymes comprises two steps, (1) preparation of proliposomes; (2) encapsulation of proliposomes.

[0071] (1) The present invention adopts the fluidized bed coating method to prepare the proliposome of biological enzyme. Proceed as follows:

[0072] The carrier is pulverized and sieved; and mixed evenly with the biological enzyme powder according to the equal amount incremental method and set aside.

[0073] Dissolve the lipid and polyvinylpyrrolidone in 4 times the amount of absolute ethanol.

[0074] Spray in the mixed bio-enzyme powder by means of fluidized bed rotary cutting spray, dry at 50°C for 50 minutes after spraying, take out and sieve.

[0075] (2) The present invention adopts fluidized bed spray drying technology to wrap the proliposome containing biological enzyme to form the microparticles of wrapped biological enzyme, the steps are as follows:

[0076] Select the core, take the bioenzy...

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Abstract

The invention discloses a bio-enzyme-wrapped microparticle and a preparation method and application thereof. The bio-enzyme-wrapped microparticle comprises a core, a water-soluble shell, a bio-enzyme-wrapped proliposome and a filling agent filling a space among the core, the water-soluble shell and the bio-enzyme-wrapped proliposome, wherein a bio-enzyme is a composition of glucanase and alkaline protease. According to the bio-enzyme-wrapped microparticle and the preparation method and application thereof, the bio-enzyme can stably exist in various oral care products such as toothpaste and tooth powder through a wrapping technique, and the oral care products have the effects of decomposing dental plaques, removing tooth stain, whitening the teeth and refreshing the oral smell.

Description

technical field [0001] The invention relates to the technical field of oral care products, in particular to microparticles coated with biological enzymes and a preparation method and application thereof. Background technique [0002] Teeth whitening has become an important part of human oral health. Along with the improvement day by day of people's living standard, people also strengthen day by day to the concern of tooth whitening. According to the statistics of AC Nielsen, a world-renowned research company, whitening oral care products in my country have become the largest sub-category, with a market size of more than 6 billion yuan. [0003] The development of tooth whitening products is a field that has been studied more in recent years. Exogenous stains on teeth are mainly caused by drinking pigmented beverages, eating pigmented foods and smoking. Whitening oral care products can remove stains on the tooth surface and restore the original color of tooth enamel. Ther...

Claims

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Application Information

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IPC IPC(8): A61K8/02A61K8/14A61K8/66A61K8/73A61K8/60A61Q11/00
CPCA61K8/0245A61K8/14A61K8/60A61K8/66A61K8/731A61K8/732A61Q11/00
Inventor 江山
Owner 广东百润和健康科技有限公司
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