Human brain local water distribution volume measuring method using first A% region as reference region

A measurement method and water distribution technology, applied in the field of biological and medical imaging, can solve problems such as insufficient accuracy, achieve good application scenarios, and facilitate automatic processing

Inactive Publication Date: 2016-10-12
NANJING UNIV OF INFORMATION SCI & TECH
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Problems solved by technology

[0008] In order to solve the deficiencies of the prior art, the object of the present invention is to provide a method for measuring the local water distribution volume of the human brain in

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  • Human brain local water distribution volume measuring method using first A% region as reference region
  • Human brain local water distribution volume measuring method using first A% region as reference region
  • Human brain local water distribution volume measuring method using first A% region as reference region

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Embodiment Construction

[0025] The present invention will be specifically introduced below in conjunction with the accompanying drawings and specific embodiments.

[0026] refer to figure 1 As shown, the method for measuring the local water distribution volume of the human brain in the front A% area of ​​the present invention as the reference area is a PET / H method for the local water distribution volume of the human brain. 2 15 O non-invasive quantitative measurement method, which can quantitatively measure the human brain pixel by pixel, and then generate functional images of the local water distribution volume of the human brain. In order to realize the above-mentioned purpose of the invention, the present invention is achieved by taking the following technical solutions:

[0027] The method for quantitatively measuring the volume of distribution of human brain local water as a reference area in the front A% area is characterized in that:

[0028] (1) PET / H for human brain 2 15 O dynamic scan...

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Abstract

The invention discloses a human brain local water distribution volume measuring method using first A% region as a reference region. The method is characterized by comprising the following steps: step 1, performing PET/H2<15>O dynamic scanning on a human brain; step 2, using the first A% region as a reference region, calculating relative water distribution volume value P1 of each to-be-determined position in the human brain; step 3, after the relative water distribution volume value P1 of each position of the human brain is obtained, performing normalization processing on the human brain as needed; and difference between an obtained numerical value and an absolute water distribution volume of the position being a proportional constant, and using the obtained numerical value as an index of the absolute water distribution volume. The method does not need to dynamically draw arterial blood and does not need a template or a model which may distort, and complex correction and other manual intervention are not needed, so that the method can realize automatic processing of computers. A measured result and an accurate local water distribution volume quantitative measuring method do not have deviation, and the method has good application prospect.

Description

technical field [0001] The invention relates to a method for measuring the local water distribution volume of the human brain, in particular to a method for measuring the local water distribution volume of the human brain using the front A% area as a reference area. The invention belongs to the field of biological and medical imaging. Background technique [0002] Using Positron Radionuclides 15 O labeled water (i.e. H 2 15 O) Positron Emission Tomography (PET) method (abbreviated as PET / H) as imaging agent 2 15 O method) is to perform PET dynamic scanning after intravenous injection of H215O, and then use the Kety-Schmidt single-chamber model (see Kety SS. (1951) The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 3 :1-41.) and other methods are used to quantitatively calculate the local water distribution volume pixel by pixel, so that the image of the local water distribution volume can be generated. [0003] In the early...

Claims

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Application Information

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IPC IPC(8): A61B6/03
CPCA61B6/037A61B6/469A61B6/481A61B6/501A61B6/52
Inventor 吴义根郑改革赵德林
Owner NANJING UNIV OF INFORMATION SCI & TECH
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