ENST00000509938.1 and preparation or diagnostic agent or drug or kit and application thereof
A technology of kits and diagnostic agents, applied in the field of genetic engineering, can solve problems such as the unclear role of genetics
Inactive Publication Date: 2016-11-09
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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Problems solved by technology
[0005] The present invention provides a long-chain non-coding RNA ENST00000509938.1 and its preparation or diagnostic agent or medicine or kit and application, which overcomes the deficiencies of the above-mentioned prior art, and can effectively solve the problem of acute myocardial infarction as a disease affected by various diseases. Diseases affected by genetic and environmental factors, but the role of genetics in the pathogenesis of acute myocardial infarction is still unclear. The present invention finds that its abnormal expression or function is closely related to the occurrence and development of human cardiovascular diseases. Long non-coding RNA ENST00000509938 .1 It is expected to become a marker for the diagnosis and prognosis of cardiovascular diseases, and it also provides a new target for the treatment of cardiovascular diseases
Method used
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Embodiment 1
[0026] Example 1, a long non-coding RNA ENST00000509938.1 highly expressed in the blood of patients with acute myocardial infarction, the sequence of the long non-coding RNA ENST00000509938.1 is shown in SEQ ID NO:1.
Embodiment 2
[0027] Example 2, as an optimization of Example 1, the long non-coding lncRNA ENST00000509938.1 is the full length of ENST00000509938:1
Embodiment 3
[0028] Embodiment 3, a preparation or diagnostic agent or medicine or kit for in vitro detection of long-chain non-coding RNAENST00000509938.1 in blood according to Embodiment 1 or Embodiment 2, the preparation or diagnostic agent or medicine or kit comprises Specific primer pair, standard DNA template, PCR reaction liquid, wherein, specific primer pair comprises upstream primer and downstream primer, the nucleotide sequence of upstream primer is SEQ ID No: 2, and the nucleotide sequence of downstream primer is SEQ ID No: 3.
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The invention relates to the technical field of gene engineering, and relates to a long non-coding RNA ENST00000509938.1, and a kit and an application thereof. The long non-coding RNA and a preparation or a diagnostic agent or a drug or the kit and the application thereof are provided; a gene sequence of the long non-coding RNA has a sequence as shown in SEQ ID No:1. Compared with the blood content of health people, the long non-coding RNA ENST00000509938.1 is significantly highly expressed in blood of patients with acute myocardial infarction. The long non-coding RNA ENST00000509938.1 can further enrich researches on a pathogenesis of acute myocardial infarction, and also provides new blood biomarkers and therapeutic targets for early diagnosis and prognosis monitoring of acute myocardial infarction.
Description
technical field [0001] The present invention relates to the technical field of genetic engineering, and relates to a LncRNA ENST00000509938.1 and a preparation or a diagnostic agent or a medicine or a kit and an application, that is, ENST00000509938.1 and a preparation or a diagnostic agent or a medicine or a kit and an application. Background technique [0002] Acute myocardial infarction (AMI), as a more serious type of coronary heart disease (CHD), has an acute onset and a high mortality rate, posing a serious threat to people's health. At present, the diagnosis of acute myocardial infarction mostly depends on clinical manifestations, dynamic changes of electrocardiogram and serum biomarkers. How to diagnose and prevent acute myocardial infarction earlier has always been an important topic of our research. With the completion of the Human Genome Project and the development of gene chip technology, many causative genes of single-gene diseases have been discovered and appl...
Claims
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IPC IPC(8): C12N15/113C12Q1/68C12N15/11
CPCC12N15/113C12N2310/10C12Q1/6883C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 李晓梅杨毅宁翟慧马依彤刘芬陈邦党谢翔向阳廖武
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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